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Figure 2: Clinical photographs of patient 2. (a) Tiny papules around the nose and mouth at first visit. (b) Patient appearance after 27 months, following treatments with oral roxithromycin, topical tacrolimus, topical metronidazole and topical benzoyl peroxide/clindamycin. (c) Histological examination of perioral skin papule demonstrates granulomatous infiltration around hair follicles (H and E, ×100). (d) Non-caseating granulomas consisting of lymphocytes, histiocytes, and multinucleated giant cells are observed in the perifollicular area. (H and E, ×200)

Figure 2: Clinical photographs of patient 2. (a) Tiny papules around the nose and mouth at  first visit. (b) Patient appearance after 27 months, following treatments with oral roxithromycin, topical tacrolimus, topical metronidazole and topical benzoyl peroxide/clindamycin. (c) Histological examination of perioral skin papule demonstrates granulomatous infiltration around hair follicles (H and E, ×100). (d) Non-caseating granulomas consisting of lymphocytes, histiocytes, and multinucleated giant cells are observed in the perifollicular area. (H and E, ×200)