Indian J Med Microbiol Close
 

Figure 2: Ultrathin sections of sensitive strain of promastigote forms of Leishmania tropica revealed different ultrastructural alteration induced by treatment with meglumine antimoniate (Glucantime). (a) Nucleus became elongated; nuclear chromatin became fragmented and dispensed instead of rimming around nuclear membrane, mitochondrial swelling, loss of its matrix and cristae. (b) Kinetoplast DNA core was condensed, vacuolization of flagellar pocket. (c) Intense vacuolization (V) of cytoplasm. Intense vesiculation (v) were seen. (d) Enlarged view of the kinetoplast. (e) Enlarged view of the vacuole and vesicles. Bars are 3 ìm

Figure 2: Ultrathin sections of sensitive strain of promastigote forms of Leishmania tropica revealed different ultrastructural alteration induced by treatment with meglumine antimoniate (Glucantime). (a) Nucleus became elongated; nuclear chromatin became fragmented and dispensed instead of rimming around nuclear membrane, mitochondrial swelling, loss of its matrix and cristae. (b) Kinetoplast DNA core was condensed, vacuolization of flagellar pocket. (c) Intense vacuolization (V) of cytoplasm. Intense vesiculation (v) were seen. (d) Enlarged view of the kinetoplast. (e) Enlarged view of the vacuole and vesicles. Bars are 3 ìm