Indian Journal of Dermatology
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   2016| November-December  | Volume 61 | Issue 6  
    Online since November 9, 2016

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Evaluation of clinical significance of dermoscopy in alopecia areata
Akhila Sai Guttikonda, Chintaginjala Aruna, DVSB Ramamurthy, K Sridevi, Senthil Kumar L Alagappan
November-December 2016, 61(6):628-633
DOI:10.4103/0019-5154.193668  PMID:27904180
Background: Alopecia areata (AA) is a common, chronic inflammatory disease characterized by nonscarring hair loss on the scalp or any hair-bearing area of the body. Recently, dermoscopy, a noninvasive diagnostic procedure, has been employed for the diagnosis of AA. Aim: To evaluate various dermoscopic patterns in AA and correlate these patterns with the disease activity and severity. Materials and Methods: Dermoscopy was performed on AA patients using DL1 dermoscope (magnification ×10 was used). The dermoscopic patterns recorded were analyzed to identify any correlation with the disease activity and severity. Results: A total of fifty patients of AA were recruited in the study. Female outnumbered males with the ratio being 1.173:1. Mean age of the patients was 25.06 years. Mean duration of disease was 14 months. The most common site involved was scalp (80%) and type noted was patchy (84%). Various dermoscopic patterns noted were yellow dots (YD) (88%), short vellus hair (66%), black dots (BD) (58%), broken hairs (BHs) (56%), tapering hair (TH) (26%), Coudability hairs (14%), pigtail hair (14%), and Pohl-Pinkus constrictions (2%). Statistically significant correlation was observed between BD, BHs, THs, and disease activity. No significant correlation was found between severity and any of the dermoscopic features. Conclusion: The most common dermoscopic pattern in our study was YD. Presence of BDs, BHs, and THs indicate active disease. Dermoscopic patterns were not affected by severity of the disease.
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Biostatistics series module 6: Correlation and linear regression
Avijit Hazra, Nithya Gogtay
November-December 2016, 61(6):593-601
DOI:10.4103/0019-5154.193662  PMID:27904175
Correlation and linear regression are the most commonly used techniques for quantifying the association between two numeric variables. Correlation quantifies the strength of the linear relationship between paired variables, expressing this as a correlation coefficient. If both variables x and y are normally distributed, we calculate Pearson's correlation coefficient (r). If normality assumption is not met for one or both variables in a correlation analysis, a rank correlation coefficient, such as Spearman's rho (ρ) may be calculated. A hypothesis test of correlation tests whether the linear relationship between the two variables holds in the underlying population, in which case it returns a P < 0.05. A 95% confidence interval of the correlation coefficient can also be calculated for an idea of the correlation in the population. The value r2 denotes the proportion of the variability of the dependent variable y that can be attributed to its linear relation with the independent variable x and is called the coefficient of determination. Linear regression is a technique that attempts to link two correlated variables x and y in the form of a mathematical equation (y = a + bx), such that given the value of one variable the other may be predicted. In general, the method of least squares is applied to obtain the equation of the regression line. Correlation and linear regression analysis are based on certain assumptions pertaining to the data sets. If these assumptions are not met, misleading conclusions may be drawn. The first assumption is that of linear relationship between the two variables. A scatter plot is essential before embarking on any correlation-regression analysis to show that this is indeed the case. Outliers or clustering within data sets can distort the correlation coefficient value. Finally, it is vital to remember that though strong correlation can be a pointer toward causation, the two are not synonymous.
  6,233 263 -
Topical steroid awareness and abuse: A prospective study among dermatology outpatients
TS Nagesh, A Akhilesh
November-December 2016, 61(6):618-621
DOI:10.4103/0019-5154.193666  PMID:27904178
Background: Topical steroids are one of the most commonly abused drugs. There are only a few studies available which have highlighted the severity of this problem in India. However, these studies have concentrated mainly on the topical steroid abuse and its side effects over the face. Aims: The aim of this study was to know the awareness among the people about various commonly available topical steroids and their combinations irrespective of usage and to know the extent of misuse of these drugs. Along with this, we also tried to find the source of recommendation of these medicines which will help to sensitize people about this menace. Materials and Methods: This was a prospective, questionnaire-based study done at a tertiary care hospital. A total of 1000 adult patients attending the dermatology outpatient department were administered a questionnaire about awareness and usage of topical steroid and its combinations. Results: A total of 1000 adult patients were included in the study, out of which 809 (80.9%) patients had heard about at least one of the topical steroids or its combinations mentioned in the questionnaire. Six hundred and twelve (61.2%) patients had used these creams. Acne and pigmentation were the most common indications for which topical steroid was used. These medicines were recommended by general practitioners in 302 (49.5%) patients and pharmacists in 71 (11.6%) patients. Totally, 318 (51.9%) patients complained of some form of side effect after using these creams. Aggravation of the symptoms and increased pigmentation were the most common adverse effects. Conclusion: Misuse of topical steroids not just over the face but also as a cream for any skin problem is quite common. Most of the times, it is recommended by general practitioners or pharmacists. It is very important to sensitize these people about the possible complications of these drugs and the extent of problem the society is facing because of irrational and unregulated use of these drugs.
  5,910 234 -
A clinicopathological and dermoscopic correlation of seborrheic keratosis
Geethu Francis Alapatt, D Sukumar, M Ramesh Bhat
November-December 2016, 61(6):622-627
DOI:10.4103/0019-5154.193667  PMID:27904179
Background: Seborrheic keratosis (SK) is the most common benign epidermal tumor of the skin. Even though SK has been well characterized clinically, dermoscopically, and histopathologically, data regarding clinical dermoscopic and histopathological correlation of different types of SK are inadequate. Aim: We carried out this study to establish any correlation between the clinical, dermoscopic, and histopathological appearance of SK and its variants. Methods: This was a descriptive study. Patients with SK were evaluated with respect to age, sex, family history of similar lesions, site of lesions, and symptoms associated with the lesions. Dermoscopy was performed in all cases. Biopsies were taken from the lesions and assessed for histopathology. Results: The most common age group affected by SK was 31-50 years (42%). A female preponderance of 76% was seen. Majority of our patients had a positive family history (62%), though Sun exposure was not seen to be a major factor. The most common clinical variant was common SK (CSK) (46%). The most common dermoscopic findings seen in CSK were comedo-like (CL) openings, fissures and ridges (FR), and milia-like (ML) cysts. Dermatosis papulosa nigra and pedunculated SK had characteristic FR and CL openings on dermoscopy. Stucco keratoses showed network-like (NL) structures and sharp demarcation. CL opening on dermoscopy corresponded to papillomatosis and pigmentation, ML cysts corresponded to horn cysts, FR corresponded to papillomatosis, and NL structures corresponded to an increase in basal layer pigmentation. Conclusions: This study emphasizes the use of dermoscopy in improving the diagnostic accuracy of SK. The correlation between the various histological and dermoscopic features is described.
  5,955 179 -
Safety of topical medications for scabies and lice in pregnancy
Viral M Patel, W Clark Lambert, Robert A Schwartz
November-December 2016, 61(6):583-587
DOI:10.4103/0019-5154.193659  PMID:27904173
Medications should be employed with caution in women of childbearing age. Topical medications have little systemic absorption. Therefore, they are considered safer than oral or parenteral agents and less likely to be embryotoxic or fetotoxic. However, their safety profile must be assessed cautiously as the available data are limited. In this article, we aggregate human and animal studies to provide recommendations on using topical anti-scabies and anti-lice therapy in pregnancy.
  5,295 264 -
Current understanding in pathogenesis of atopic dermatitis
Tess McPherson
November-December 2016, 61(6):649-655
DOI:10.4103/0019-5154.193674  PMID:27904184
There have been advances in our understanding of the complex pathogenesis of atopic eczema over the past few decades. This article examines the multiple factors which are implicated in this process.
  5,252 230 -
Adult-onset atopic dermatitis
Amrinder Jit Kanwar
November-December 2016, 61(6):662-663
DOI:10.4103/0019-5154.193679  PMID:27904186
Adult-onset atopic dermatitis is still an under recognized condition as there are only few studies regarding this entity. As compared to childhood onset atopic dermatitis, clinical features of adult onset atopic dermatitis are still not categorized. Adult atopic dermatitis can present for the first time in adult age with atypical morphology or may progress from childhood onset. This article reviews the characteristic clinical features of adult atopic dermatitis, associated risk factors and management.
  5,071 214 -
Topical therapy in atopic dermatitis in children
Dharshini Sathishkumar, Celia Moss
November-December 2016, 61(6):656-661
DOI:10.4103/0019-5154.193677  PMID:27904185
Atopic dermatitis (AD) is a common, chronic childhood skin disorder caused by complex genetic, immunological, and environmental interactions. It significantly impairs quality of life for both child and family. Treatment is complex and must be tailored to the individual taking into account personal, social, and emotional factors, as well as disease severity. This review covers the management of AD in children with topical treatments, focusing on: education and empowerment of patients and caregivers, avoidance of trigger factors, repair and maintenance of the skin barrier by correct use of emollients, control of inflammation with topical corticosteroids and calcineurin inhibitors, minimizing infection, and the use of bandages and body suits.
  4,655 214 -

November-December 2016, 61(6):0-0
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  4,745 64 -
Comparative evaluation of topical 10% potassium hydroxide and 30% trichloroacetic acid in the treatment of plane warts
Sandhaya Jayaprasad, Radhakrishnan Subramaniyan, Shalini Devgan
November-December 2016, 61(6):634-639
DOI:10.4103/0019-5154.193670  PMID:27904181
Background: Warts are benign proliferations of skin and mucosa caused by the human papillomavirus (HPV). Plane warts are caused by HPV types 3, 10, 28, and 41, occurring mostly in children and young adults. Among the treatment modalities, topical application of trichloroacetic acid (TCA) is age old. Potassium hydroxide (KOH) has a keratolytic effect on virus-infected cells. It is less irritating, less painful, less scar forming, and can be safely used in children too. Hence, it could be a better topical agent in the treatment of plane warts. Aims and Objectives: To compare the safety and efficacy of topical 10% KOH with 30% TCA in the treatment of plane warts. Materials and Methods: Sixty consecutive patients with plane warts were randomly assigned into two arms of thirty patients each; arm A received topical 10% KOH and arm B received topical 30% TCA as a once weekly application until the complete clearance of warts or a maximum period of 12 weeks. Results: Statistically no significant difference (P = 0.07) was found between the objective therapeutic response to 10% KOH and 30% TCA at the end of study (12 weeks). However, subjective response to 10% KOH was better and statistically significant (P = 0.03). There was no recurrence of warts seen on follow-up for 3 months of complete responders in both the arms. Conclusion: 10% KOH is found to be equally effective in the treatment of plane warts compared to 30% TCA with the advantage of faster onset of action and tendency of completely clearing warts with fewer side effects.
  4,541 110 -
Food allergy in atopic dermatitis
Sandipan Dhar, Sahana M Srinivas
November-December 2016, 61(6):645-648
DOI:10.4103/0019-5154.193673  PMID:27904183
Food allergy in atopic dermatitis (AD) is debatable from decades. Role of diet in the cause and treatment of AD is controversial and is not well-defined. Allergists and pediatricians are convinced about the food allergy in AD whereas many dermatologists are contrary for this. However, there are studies in the Indian and western literature supporting the evidence that elimination diet may improve the severe type of AD. There is increasing awareness and lot of misconception among caregivers about food allergy and hence careful understanding about this concept is necessary to counsel parents. Recent evidence-based literature suggests avoidance of proven food allergens in AD could be beneficial in moderate to severe type of AD.
  4,388 173 -
Branchial cleft cyst
Vaishali Nahata
November-December 2016, 61(6):701-701
DOI:10.4103/0019-5154.193718  PMID:27904209
Branchial cleft cyst, sinuses, and fistulae are among the most commonly encountered congenital anomalies in pediatric otolaryngic practice. They can present difficulty in diagnosis and surgical management. Here, I report a case of 14-year-old boy who presented with asymptomatic, congenital swelling located just below the jawline in the lateral part of the neck. The lesion was excised surgically. Histopathology showed the cyst lined by squamous as well as columnar ciliated epithelium, which was a characteristic finding of branchial cleft cyst. The aim of presenting this case is its rarity.
  4,118 50 -
Daytime changes of skin biophysical characteristics: A study of hydration, transepidermal water loss, ph, sebum, elasticity, erythema, and color index on middle eastern skin
Alireza Firooz, Hamed Zartab, Bardia Sadr, Leili Naraghi Bagherpour, Aidin Masoudi, Ferial Fanian, Yahya Dowlati, Amir Hooshang Ehsani, Aniseh Samadi
November-December 2016, 61(6):700-700
DOI:10.4103/0019-5154.193707  PMID:27904203
Background: The exposure of skin to ultraviolet radiation and temperature differs significantly during the day. It is reasonable that biophysical parameters of human skin have periodic daily fluctuation. The objective of this study was to study the fluctuations of various biophysical characteristics of Middle Eastern skin in standardized experimental conditions. Materials and Methods: Seven biophysical parameters of skin including stratum corneum hydration, transepidermal water loss, pH, sebum, elasticity, skin color, and erythema index were measured at three time points (8 a.m., 12 p.m. and 4 p.m.) on the forearm of 12 healthy participants (mean age of 28.4 years) without any ongoing skin disease using the CK MPA 580 device in standard temperature and humidity conditions. Results: A significant difference was observed between means of skin color index at 8 a.m. (175.42 ± 13.92) and 4 p.m. (164.44 ± 13.72, P = 0.025), between the pH at 8 a.m. (5.72 ± 0.48) and 4 p.m. (5.33 ± 0.55, P = 0.001) and pH at 12 p.m. (5.60 ± 0.48) and 4 p.m. (5.33 ± 0.55, P = 0.001). Other comparisons between the means of these parameters at different time points resulted in nonsignificant P values. Conclusion: There are daytime changes in skin color index and pH. Skin color index might be higher and cutaneous pH more basic in the early morning compared to later of the day.
  3,732 60 -
Comparative study of efficacy of epidermal melanocyte transfer versus hair follicular melanocyte transfer in stable vitiligo
Navya Donaparthi, Ajay Chopra
November-December 2016, 61(6):640-644
DOI:10.4103/0019-5154.193671  PMID:27904182
Background: Vitiligo surgery has come up a long way from punch skin grafts to epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension (EHFORSCS) transplantation. The progressive development from one technique to the other is always on a quest for the best. In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo. However, it needs to be explored further in larger, clinical trials. Methodology: A total of 11 patients with sixty stable vitiligo sites attending dermatology outpatient department were included for the open-labeled, prospective, comparative study. The sites were sequentially distributed into two groups of thirty each. Sites of one group were subjected to epidermal melanocyte transfer (EMT) and the others to hair follicular melanocyte transfer (HFMT). Response to treatment was evaluated on the basis of degree of repigmentation; final evaluation of area of involvement was done after completion of 6 months. Results: At the end of 6 months, repigmentation >90% was observed in 83.33% patches of EMT group and 43.33% in HFMT group. Repigmentation >75% was observed in 90% of patches in Group A and 43.34% of patches in Group B, respectively. There was statistically significant difference in the overall pigmentation between these two groups. Conclusion: Both noncultured autologous epidermal cell suspension transfer and noncultured EHFORSCS transfer are safe and effective surgical modalities in the management of stable vitiligo though EMT has shown a better response in the present study. Outer root sheath cell suspension transfer is a novel, minimally invasive technique in its nascent stage in the surgical management of vitiligo which requires further larger clinical trials for evaluation of its efficacy.
  3,542 133 -
Cutaneous manifestations of multiple myeloma
Binodini Behera, Monali Pattnaik, Bharti Sahu, Prasenjeet Mohanty, Swapna Jena, Liza Mohapatra
November-December 2016, 61(6):668-671
DOI:10.4103/0019-5154.193682  PMID:27904188
Multiple myeloma (MM) is a proliferative disorder of plasma cells which produce abnormal immunoglobulin proteins. Skin involvement is rarely found in this disorder. They are either specific or nonspecific lesions. We report four such interesting patients who presented to us initially with common dermatoses such as leukocytoclastic vasculitis, pyoderma gangrenosum, and vesiculobullous disorders and were subsequently diagnosed to have MM. There were no skeletal involvements or renal function abnormality at the time of presentation. Unusual presentation, nonresponsiveness to conventional therapy, and abnormal blood parameters prompted us to suspect some underlying systemic conditions which were later confirmed to be MM after serum immunoelectrophoresis for M-band and bone marrow biopsy.
  3,397 96 -
On the history of classification in dermatology
Amiya Kumar Mukhopadhyay
November-December 2016, 61(6):588-592
DOI:10.4103/0019-5154.193661  PMID:27904174
Since the early days of cutaneous medicine, naming of the entities had remained a confusing subject. Earlier texts of all ancient civilisations are almost similar in this topic The Biblical controversy regarding the actual translational meaning of the original Hebrew term Zara 'at has become a centre of controversy amongst many research scholars of the medical history. Similar debate exists about the Ayurvedic term Kustha---- whether it meant leprosy or stood for a number of skin affliction is a matter of controversy. A scientific and rational classification system was, therefore needed. The process started with Galen and traversed a long path and ultimately with the eight orders classification system proposed by Robert Willan in the early part of the nineteenth century resolved the issue. This whole journey was eventful....almost all the great doyens of dermatology directly or indirectly contributed to this process. This overview will focus on the main such events of the medical history in nutshell.
  2,987 117 -
A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India
Anza Khader, Shiny Padinjarayil Manakkad, Mohammed Shaan, Sarita Sasidharan Pillai, Najeeba Riyaz, P Binitha Manikoth, Muhammed Kunnummel, Sunitha Balakrishnan
November-December 2016, 61(6):608-617
DOI:10.4103/0019-5154.193665  PMID:27904177
Background: Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India. Aim: To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patients Materials and Methods: This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. The patients underwent clinical examination, human T-cell lymphotropic virus-1 (HTLV-1) screening, skin biopsy with hematoxylin and eosin and immunohistochemistry staining. Results: Among 35 cases, 33 (94.3%) were T-cell, and 2 (5.7%) were B-cell lymphomas. The mean age was 52.66, and the male to female ratio was 2.5:1. The most common types of T-cell lymphomas included mycosis fungoides (MF) (57.1%) followed by adult T-cell lymphoma/leukemia (ATL) (17.1%). Primary cutaneous peripheral T-cell lymphoma not otherwise specified was diagnosed in 17.1% and anaplastic large cell lymphoma in 2.9%. The morphological types of MF included polymorphic, poikilodermatous, folliculotropic, hypopigmented, hyperpigmented, mixed, and purpuric. Skin manifestations of ATL included ulcerated plaques and erythroderma. Epidermotropism was very marked in ATL (83.3%) than in MF (70%). Larger Pautrier's microabscess was noted in ATL compared to smaller ones in MF. Markedly dense, diffuse infiltrate of atypical cells was noted in ATL in contrast to mild to moderate nodular or perivascular infiltrate in MF. ATL had an extremely poor prognosis. Limitations: Identification of DNA integration of HTLV-1 by Southern blot could not be analyzed, and the number of cases studied is limited. Conclusions: The study showed unique patterns of subtypes of cutaneous lymphomas in our country. Variations in the clinical pattern and histopathological analysis will help to differentiate T-cell lymphoma types which have prognostic implications.
  2,563 120 -
Methodology series module 6: Systematic reviews and meta-analysis
Maninder Singh Setia
November-December 2016, 61(6):602-607
DOI:10.4103/0019-5154.193663  PMID:27904176
Systematic reviews and meta-analysis have become an important of biomedical literature, and they provide the "highest level of evidence" for various clinical questions. There are a lot of studies - sometimes with contradictory conclusions - on a particular topic in literature. Hence, as a clinician, which results will you believe? What will you tell your patient? Which drug is better? A systematic review or a meta-analysis may help us answer these questions. In addition, it may also help us understand the quality of the articles in literature or the type of studies that have been conducted and published (example, randomized trials or observational studies). The first step it to identify a research question for systematic review or meta-analysis. The next step is to identify the articles that will be included in the study. This will be done by searching various databases; it is important that the researcher should search for articles in more than one database. It will also be useful to form a group of researchers and statisticians that have expertise in conducting systematic reviews and meta-analysis before initiating them. We strongly encourage the readers to register their proposed review/meta-analysis with PROSPERO. Finally, these studies should be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis checklist.
  2,304 224 -
Myelitis: A rare neurological complication of herpes zoster
Monika Mohanbhai Agrawal, Rashmi Samir Mahajan, Freny Erachshaw Bilimoria, Kishan Rasubhai Ninama
November-December 2016, 61(6):687-689
DOI:10.4103/0019-5154.193695  PMID:27904197
  2,427 92 -
Eczema coxsackium
Satyaki Ganguly, Sheela Kuruvila
November-December 2016, 61(6):682-683
DOI:10.4103/0019-5154.193691  PMID:27904194
  2,381 59 -
Neutrophilic eccrine hidradenitis in a child with chronic granulomatous disease
Vibhu Mendiratta, Sarita Sanke, Ram Chander
November-December 2016, 61(6):683-684
DOI:10.4103/0019-5154.193693  PMID:27904195
  2,308 49 -
Reticulate pigmentation associated with scarring alopecia in an elderly woman: An unusual manifestation of lichen planus pigmentosus
Vinod Kumar Sharma, Neetu Bhari, Sweta Subhadarshani, Neha Taneja, Rakesh Kumar Deepak
November-December 2016, 61(6):700-700
DOI:10.4103/0019-5154.193713  PMID:27904206
A 70-year-old woman presented with generalized reticulate pigmentation, scarring alopecia, and few discrete, violaceous plaques over the trunk and forearm. Dermoscopic evaluation of the reticulate plaque showed reticulate hyperpigmentation with multiple telangiectasias, and skin biopsy showed lichenoid interface dermatitis with marked pigment incontinence. Thus, a final diagnosis of poikiloderma due to lichen planus pigmentosus was considered.
  2,300 57 -
Cutaneous angiosarcoma simulating as pyoderma in a middle-aged Indian female: A rare case report
Shweta Rana, Kalpana Gupta, Aekta Shah, Nidheesh Agarwal
November-December 2016, 61(6):685-687
DOI:10.4103/0019-5154.193694  PMID:27904196
  2,218 40 -
Acrofacial vitiligo following halo formation around congenital melanocytic naevi
Lalit Kumar Gupta, Chesta Agrawal, Ashok Kumar Khare, Asit Mittal, Sharad Mehta, Manisha Balai
November-December 2016, 61(6):691-692
DOI:10.4103/0019-5154.193700  PMID:27904199
  2,059 54 -
A rare case of juvenile systemic lupus erythematosus with disseminated histoplasmosis
Piyabi Sarkar, Keya Basu, Mamata Guha Mallick (Sinha)
November-December 2016, 61(6):700-700
DOI:10.4103/0019-5154.193710  PMID:27904204
Histoplasmosis is a systemic fungal infection caused by dimorphic fungus, Histoplasma capsulatum. Immunocompetent individuals usually have self-limiting or localized disease whereas immunocompromised individuals develop disseminated disease. The occurrence of progressive disseminated histoplasmosis in juvenile systemic lupus erythematosus is extremely rare with only one reported case in literature showing such association. Therefore, we report a case of severe opportunistic fungal infection caused by Histoplasma in a 13-year-old girl who was diagnosed with juvenile lupus erythematosus, subsequently developed septic shock and died of the disease despite of aggressive antifungal therapy.
  1,999 58 -
An old woman with a lump
Pooja Arora, Kabir Sardana, Anjali Madan, Nita Khurana
November-December 2016, 61(6):697-699
DOI:10.4103/0019-5154.193705  PMID:27904202
  1,957 64 -
Primary cutaneous synovial sarcoma: An extremely rare report of superficial synovial sarcoma
Nastaran Namazi, Morteza Ghassemipour, Azadeh Rakhshan, Ata Abbasi
November-December 2016, 61(6):701-701
DOI:10.4103/0019-5154.193715  PMID:27904207
Synovial sarcoma is a type of malignancy which usually occurs near the joints of the arm, neck, or leg. It is a sarcoma of soft tissue and accounts for 5-10% of all adult soft tissue sarcomas in the world. We present a case with primary superficial cutaneous synovial sarcoma without involvement of the underlying knee joint. It is a very rare condition, and to the best of our knowledge, it is the second report of this topic. Although it is rare among soft tissue tumors, the dermatologists should have precise attention to this skin tumor, as early diagnosis is associated with lower metastatic rate and therefore better prognosis.
  1,979 38 -
Focal dermal hypoplasia with a de novo mutation p.e300* of porcn gene in a male infant
Swathi Sunil Rao, Rathika D Shenoy, Smrithi Salian, Katta M Girisha
November-December 2016, 61(6):700-700
DOI:10.4103/0019-5154.193712  PMID:27904205
Focal dermal hypoplasia is a rare disorder inherited in an X-linked dominant pattern and is usually antenatally lethal in males. We report a surviving male with postzygotic de novo mutation p.E300* in exon 10 of PORCN gene with mosaicism, earlier reported in a female of Thai origin. This is the first report of this mutation from the Indian subcontinent.
  1,938 43 -
Coexistence of two different morphological forms of cutaneous tuberculosis: A report of two cases
Joly Seth, Abhijit Saha, Surajit Gorai, Kaushik Shome, Asit Baran Samanta, Subrata Pal
November-December 2016, 61(6):689-691
DOI:10.4103/0019-5154.193698  PMID:27904198
  1,911 51 -
Verrucous onychomycosis caused by curvularia in a patient with congenital pterygium
Mary Vineetha, Seena Palakkal, K Sobhanakumari, MI Celine, V Letha
November-December 2016, 61(6):701-701
DOI:10.4103/0019-5154.193717  PMID:27904208
A 57 year healthy farmer with congenital nail pterygium presented with a verrucous growth on nail bed since 8 months. He was not diabetic and HIV rapid card test negative. Our clinical diagnosis was chromoblastomycosis but culture showed growth of curvularia species on two occasions and histopathology showed hyphal and yeast forms of the pigmented fungus. After excision biopsy patient was started on oral itraconazole. This case is reported due to rarity of verrucous cutaneous lesions caused by curvularia in immunocompetent individuals.
  1,867 52 -
The relationship of psoriasis and melanocytic nevi
Fatma Pelin Cengiz, Nazan Emiroglu, Anil Gulsel Bahali, Dilek Biyik Ozkaya, Ozlem Su, Nahide Onsun
November-December 2016, 61(6):664-667
DOI:10.4103/0019-5154.193680  PMID:27904187
Background: There is limited data about the relationship between psoriasis and melanocytic lesions and melanoma. Immunologic pathways which were implicated in psoriasis induce a reduction in the number of melanocytic nevi. Aims and Objectives: To investigate the number of melanocytic nevi in psoriatic patients compared with controls and its relationship with disease severity and type of treatment. Methods: We performed a prospective study in 100 psoriatic patients and 100 controls. Clinical data were recorded for all participants. Results: As compared with controls, patients had overall fewer nevi congenital nevi. Among psoriatic patients, biologic agents and disease severity did not correlate with the number of nevi. Conclusions: Psoriatic patients have fewer nevi than controls. Frequency of nevi in psoriatic patients is not related to treatment and disease severity.
  1,833 48 -
Solitary erythematous plaque on the nasolabial fold
Anupam Das, Saumya Panda
November-December 2016, 61(6):680-682
DOI:10.4103/0019-5154.193690  PMID:27904193
  1,800 58 -
A case of relapsing polychondritis with palmoplantar pustulosis
Won Joo Kwon, Min Seok Kim, Jun Yeong Park, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
November-December 2016, 61(6):693-694
DOI:10.4103/0019-5154.193701  PMID:27904200
  1,785 37 -
A case of psoriasis encircled by porokeratosis
Indrashis Podder, Debabrata Bandyopadhyay
November-December 2016, 61(6):676-678
DOI:10.4103/0019-5154.193687  PMID:27904191
  1,645 41 -
A case of alkaptonuria with degenerative collagenous plaques and foot drop
C Chandrakala, Gurusami Karuvelan Tharini, M Ananthi, R Subha
November-December 2016, 61(6):678-680
DOI:10.4103/0019-5154.193689  PMID:27904192
  1,641 40 -
Localized glistening nodules of the right ear: A rare de novo occurrence of histoid leprosy
Aditya Kumar Bubna
November-December 2016, 61(6):694-696
DOI:10.4103/0019-5154.193703  PMID:27904201
  1,634 47 -
Author's reply: Pachyonychia congenita Type 1: Case report and review of the literature
Anupam Das
November-December 2016, 61(6):675-675
DOI:10.4103/0019-5154.193686  PMID:27904190
  1,337 42 -
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November-December 2016, 61(6):672-674
  1,260 36 -
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