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Indian Journal of Dermatology
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   2011| May-June  | Volume 56 | Issue 3  
    Online since June 30, 2011

 
 
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CASE REPORTS
Genital vitiligo following use of imiquimod 5% cream
Ruzhi Zhang, Wenyuan Zhu
May-June 2011, 56(3):335-336
DOI:10.4103/0019-5154.82501  PMID:21772604
Imiquimod is a small molecule with adjuvant pro-inflammatory effects that can be topically delivered as a cream for treating external genital and perianal warts. In our report, two Chinese males at the ages of 25 and 22 years were treated with imiquimod 5% cream for recurrent condyloma accuminatum, three times per week for 18 and 12. weeks, respectively. Depigmentation were noted and gradually enlarged in the treated areas after the two patients discontinued imiquimod. Therefore, clinicians should be made aware of the possible pigmentary changes associated with application of this cream.
  24,295 104 1
ORIGINAL ARTICLES
PASI and PQOL-12 score in psoriasis : Is there any correlation?
Vikas Shankar, Sanjay Ghosh, Kisalay Ghosh, Uday Chaudhuri
May-June 2011, 56(3):287-289
DOI:10.4103/0019-5154.82482  PMID:21772589
Background: Psoriasis, a common papulo-squamous disorder of the skin, is universal in occurrence and may interfere with the quality of life adversely. Whether extent of the disease has any bearing upon the patients' psychology has not much been studied in this part of the world. Aims: The objective of this hospital-based cross-sectional study was to assess the disease severity objectively using Psoriasis area and severity index (PASI) score and the quality of life by Psoriasis quality-of-life questionnaire-12 (PQOL-12) and to draw correlation between them, if any. Materials and Methods PASI score denotes an objective method of scoring severity of psoriasis, reflecting not only the body surface area but also erythema, induration and scaling. The PQOL-12 represents a 12-item self-administered, disease-specific psychometric instrument created to specifically assess quality-of-life issues that are more important with psoriasis patients. PASI and PQOL-12 score were calculated in each patient for objectively assessing their disease severity and quality of life. Results: In total, 34 psoriasis patients (16 males, 18 females), of age ranging from 8 to 55 years, were studied. Maximum and minimum PASI scores were 0.8 and 32.8, respectively, whereas maximum and minimum PQOL-12 scores were 4 and 120, respectively. PASI and PQOL-12 values showed minimal positive correlation (r = +0.422). Conclusion: Disease severity of psoriasis had no direct reflection upon their quality of life. Limited psoriasis on visible area may also have greater impact on mental health.
  11,971 202 -
REVIEW ARTICLE
Pathogenesis of dermatophytoses
Ram Tainwala, YK Sharma
May-June 2011, 56(3):259-261
DOI:10.4103/0019-5154.82476  PMID:21772583
Dermatophytes can survive solely on outer cornified layers of the skin. The ability of certain fungi to adhere to particular host arises from numerous mechanisms and host factors, including the ability to adapt to the human body. Natural infection is acquired by the deposition of viable arthrospores or hyphae on the surface of the susceptible individual. After the inoculation in the host skin, suitable conditions favor the infection to progress through the stages of adherence and penetration. Development of host response is mostly by a T-cell mediated response of delayed-type hypersensitivity. Antibody formation does not seem to be protective. Natural defenses against dermatophytes depend on both immunological and nonimmunological mechanisms.
  7,988 555 1
ORIGINAL ARTICLES
Mucocutaneous manifestations of chikungunya fever: A study from an epidemic in coastal Karnataka
Ramesh M Bhat, Yashaswi Rai, Amitha Ramesh, B Nandakishore, D Sukumar, Jacintha Martis, Ganesh H Kamath
May-June 2011, 56(3):290-294
DOI:10.4103/0019-5154.82483  PMID:21772590
Background : Chikungunya fever (CF) epidemic has recently re-emerged in India affecting large population. Mucocutaneous manifestations are an important clinical feature of the disease. We have reviewed mucocutaneous manifestations of the disease during a recent epidemic in coastal Karnataka. Patients and Methods Seventy-five "suspect cases" of CF with dermatological manifestations were examined. Results : We categorized the mucocutaneous manifestation into six groups: 1. skin rash, 2. apthae like ulcers, 3. pigmentary changes, 4. desquamation, 5. exacerbation of the existing dermatoses, 6. miscellaneous. Skin rashes were the most commonly observed skin changes followed by apthae like ulcers and pigmentary changes. Desquamation of the skin over the face is a new manifestation observed by us. Conclusion : wide spectrum of mucocutaneous manifestations is observed in CF. We have provided a classification for these manifestations, which may help in better recognition and uniform recording in future.
  7,201 217 2
SHORT COMMUNICATIONS
Topical hyaluronic acid in the management of oral ulcers
Pranav Kapoor, Shabina Sachdeva, Silonie Sachdeva
May-June 2011, 56(3):300-302
DOI:10.4103/0019-5154.82485  PMID:21772592
Hyaluronic acid is a hygroscopic macromolecule formed by the polymerisation of glucuronic acid and N-acetylglucosamine disaccharide. It is a primary component of the extracellular matrix in various body tissues. Ihe use of topical Hyaluronic acid in the treatment of oral ulcers has been recently reported. This article reviews the mechanism of action, indications and efficacy of topical Hyaluronic acid gel in the management of oral ulcers.
  6,799 177 1
CME ARTICLE
Psoriasis in children: An insight
Sandipan Dhar, Raghubir Banerjee, Nilesh Agrawal, Sharmila Chatterjee, Rajib Malakar
May-June 2011, 56(3):262-265
DOI:10.4103/0019-5154.82477  PMID:21772584
Onset of psoriasis in childhood is quite common. Chronicity, inflammation and hyperproliferation are the cardinal features by which the condition establishes its uniqueness. Clearance of disease may be farfetched in most patients and relapse is frequent. Early recognition and management of psoriasis in children and adolescents is vital in therapy in children.
  6,340 401 5
CASE REPORTS
Folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: Systemic antibiosis (Metronidazole Plus Clindamycin), dermatosurgical approach, and high-dose isotretinoin
Georgi Tchernev
May-June 2011, 56(3):318-320
DOI:10.4103/0019-5154.82492  PMID:21772598
Folliculitis et perifolliculitis capitis abscedens et suffodiens is a rare disease of unknown etiology. It is a suppurative process that involves the scalp, eventually resulting in extensive scarring and irreversible alopecia. The condition is also known as 'acne necrotica miliaris' or 'Proprionibacterium' folliculitis. Most often the disease affects men of African-American or African-Caribbean descent between 20 and 40 years of age. The clinical picture is determined by fluctuating painful fistule-forming conglomerates of abscesses in the region of the occipital scalp. The cause of scalp folliculitis is not well understood. It is generally considered to be an inflammatory reaction to components of the hair follicle, particularly the micro-organisms. These include: bacteria (especially Propionibacterium acnes, but in severe cases, also Staphylococcus aureus), Yeasts (Malassezia species) and mites (Demodex folliculorum). The initial histopathologic finding is an exclusively neutrophilic infiltration followed by a granulomatous infiltrate. The treatment of the disease is usually difficult and often disappointing. Successful treatment with isotretinoin 1 mg/kg body mass could be achieved only after regular systematic administration in the course of 3-4 months. Here we describe a patient with eruptive purulent form of the disease, which has been controlled with combination therapy: systemic antibiosis with metronidazole and clindamycin, dermatosurgical removal of single nodular formations, and isotretinoin 1 mg/kg body mass for 3-5 months.
  6,330 74 2
Cervicofacial actinomycosis mimicking lymphangioma circumscriptum
Mahendra M Kura, Vrushali K Rane
May-June 2011, 56(3):321-323
DOI:10.4103/0019-5154.82493  PMID:21772599
Primary cutaneous actinomycosis caused by Actinomyces israelii occurs most commonly in the cervicofacial area. It commonly presents as "lumpy jaw" with draining sinuses which discharge the characteristic "sulfur granules". A low index of suspicion and a low sensitivity in culturing the organism, due to its fastidious nature often delays the diagnosis. An atypical clinical presentation mimicking lymphangioma circumscriptum with grouped papulovesicular and nodular lesions along the lower jaw extending from skin to the inner buccal mucosa, confirmed on histology and an excellent therapeutic response to penicillin is reported.
  6,213 82 2
Epidermolytic hyperkeratosis in inflammatory linear verrucous epidermal nevus
Naser Tayyebi Meibodi, Yalda Nahidi, Zari Javidi
May-June 2011, 56(3):309-312
DOI:10.4103/0019-5154.82488  PMID:21772595
Epidermolytic hyperkeratosis presents with perinuclear vacuolization of the keratinocytes in spinous and granular layers, keratinocytes with ill-defined limits, which leads to a reticulate appearance of the epidermis, an increased number of variously shaped and sized basophilic keratohyalin granules and the same sized eosinophilic trichohyalin granules, at any level of epidermis, mainly in the stratum granulosum, and compact hyperkeratosis. This minor reactive pathologic reaction pattern of skin is found in large variety of diseases. This paper is the first case report of such pattern in inflammatory linear verrucous epidermal nevus. Our case is of a 23-year-old man with pruritic verrucous lesions of trunk and extremities initiated since 13 years ago. Physical examination revealed white linear hyperkeratotic lesions, some of them on erythematous background and also classic epidermal nevus. No skeletal, ophthalmic, and nervous system involvement was detected. Microscopic study of pruritic verrucous lesions showed psoriasiform acanthosis, mild papillomatous, hyperkeratosis, and epidermolytic hyperkeratotic changes in hair follicles and acrosyrinx accompanied with moderate perivascular inflammation.
  6,157 106 1
Cutaneous manifestations in Brucellosis
Zeynep Karaali, Birol Baysal, Sule Poturoglu, Mehmet Kendir
May-June 2011, 56(3):339-340
DOI:10.4103/0019-5154.82505  PMID:21772606
Brucellosis is a common worldwide zoonotic disease. Cutaneous manifestations are not specific and affect 1-14% of patients with brucellosis. Here, we describe 49-year-old female with fever and a diffuse maculopapular rash due to Brucella melitensis infection. Histopathology of skin biopsy revealed leukocytoclastic vasculitis; positive blood cultures for B. melitensis established the diagnosis of brucellosis. We provide a review of the relevant literature.
  5,456 78 2
Bullous aplasia cutis congenita: Case report and review of the literature
Maria Teresa Garcia-Romero, Verůnica NarvŠez-Rosales, Maria Teresa Hojyo-Tomoka
May-June 2011, 56(3):337-338
DOI:10.4103/0019-5154.82503  PMID:21772605
Aplasia cutis congenita is a rare condition characterized by the absence of skin and sometimes other underlying structures such as bone or dura. It can be a part of various syndromes and can be associated with multiple genetic diseases, malformation patterns, or a combination of all. It is even considered as a form frustre of a neural tube defect in several literatures. Bullous aplasia cutis congenita is a clinical subtype of the condition, with extremely few cases reported in the literature. It presents as a cystic or bullous lesion at birth, which eventually transforms into an atrophic, flat scar covered by a thin epithelium. Some cases present with a dark collar hair sign around the lesion, which can be even more indicative of an underlying neural tube defect. Management remains controversial and depends on the characteristics of the lesion, but conservative treatment is usually chosen.
  4,998 63 -
Waterhouse-Friderichsen syndrome in an adult patient with meningococcal meningitis
Alka Sonavane, Vasant Baradkar, Parul Salunkhe, Simit Kumar
May-June 2011, 56(3):326-328
DOI:10.4103/0019-5154.82496  PMID:21772601
Waterhouse-Friderichsen syndrome is one of the fatal complications of meningococcal infection. Here we report a fatal case of this syndrome due to Neisseria meningitidis in a 29-year-old male patient who was admitted with high-grade fever and chills and vomiting since 7 days, a skin rash over the abdomen and trunk, and altered sensorium since 2 days. On examination, the signs of meningitis were present along with the hemorrhagic rash. The diagnosis of adrenal hemorrhage was confirmed by computerized tomographic scan findings. The patient was started on intravenous ceftriaxone, and the cerebrospinal fluid was processed for bacterial culture, which yielded growth of N meningitidis. The patient's condition deteriorated; he developed purpura along with a fall in platelet count, and died due to shock. This case is being reported as such a complication is comparatively rare in this antibiotic era, especially in adults, and starting steroids like dexamethasone prior to antibacterial therapy may be useful to diminish the inflammation brought about by bacterial cell death and thus help in reducing the otherwise high mortality in these cases.
  4,554 64 2
Phytophotodermatitis due to chinese herbal medicine decoction
Ruzhi Zhang, Wenyuan Zhu
May-June 2011, 56(3):329-331
DOI:10.4103/0019-5154.82498  PMID:21772602
A 24-year-old female presented to the clinic complaining of bizarre patterns and linear streaks of hyperpigmentation on her legs and bizarre alutaceous patches on the neck and upper breast of her son for 7 days. Physical examination showed sharply demarcated hyperpigmented streaks on the extensor aspects of legs and bizarre brown maculae and patches on the right neck and upper chest of her son. Considering the history of Chinese herbal medicine decoction had been splashed onto these sites, phytophotodermatitis was definitely diagnosed.
  4,564 49 1
ORIGINAL ARTICLES
Cutaneous manifestations of deep mycosis: An experience in a tropical pathology laboratory
Modupeola Omotara Samaila, Kabiru Abdullahi
May-June 2011, 56(3):282-286
DOI:10.4103/0019-5154.82481  PMID:21772588
Background : Cutaneous manifestations of deep mycotic infection are fraught with delayed or misdiagnosis from mainly cutaneous neoplastic lesions. Aim: This study is designed to present our experience of these mycoses in a pathology laboratory in the tropics. Materials and Methods : A clinicopathologic analysis of deep mycotic infections was conducted over a 15 years period Formalin fixed and paraffin wax processed biopsies were stained with hematoxylin and eosin, periodic acid Schiff (PAS), and Grocott's methenamine silver (GMS) for the identification of fungus specie. Patients' bio-data and clinical information were obtained from records. Results : Twenty males and seven females presented with 6 months to 6 years histories of varying symptoms of slow growing facial swellings, nodules, subcutaneous frontal skull swelling, proptosis, nasal blockage, epistaxis, discharging leg sinuses, flank mass, convulsion and pain. Of the 27 patients, four gave antecedent history of trauma, two had recurrent lesions which necessitated maxilectomy, two presented with convulsion without motor dysfunction while one had associated erosion of the small bones of the foot. None of the patients had debilitating illnesses such as diabetes mellitus, tuberculosis, and HIV infection. Tissue histology revealed histoplasmosis (10), mycetoma (9), subcutaneous phycomycosis (6), and phaeohyphomycosis (2). Conclusion : Deep mycoses may present primarily as cutaneous lesions in immunocompetent persons and often elicit distinct histologic inflammatory response characterized by granuloma formation. Diagnosis in resource constraint setting can be achieved with tissue stained with PAS and GMS which identifies implicated fungus. Clinical recognition and adequate knowledge of the pathology of these mycoses may reduce attendant patient morbidity.
  4,314 139 2
CASE REPORTS
Extensive presentation of verruca plana in a healthy individual
S Pavithra, H Mallya, GS Pai
May-June 2011, 56(3):324-325
DOI:10.4103/0019-5154.82495  PMID:21772600
A 27-year-old healthy man presented with non-itchy hyperpigmented skin lesions involving the trunk of duration 3 years. Examination revealed numerous coalescing, rough, slightly elevated brownish papules involving large areas of back, chest, and abdomen. There were no other cutaneous or systemic findings. Cutaneous biopsy was suggestive of verruca plana, which confirmed our clinical diagnosis. Here, we report this case of verruca plana due to its rare extensive involvement and unusual site in a non-immunocompromised individual.
  4,333 95 1
Multifocal tuberculosis verrucosa cutis
Jiby Rajan, Ashok Thomas Mathai, P.V.S Prasad, PK Kaviarasan
May-June 2011, 56(3):332-334
DOI:10.4103/0019-5154.82500  PMID:21772603
Tuberculosis has been a well-known affliction of human kind, since antiquity. Cutaneous tuberculosis constitutes only a small proportion of extra pulmonary tuberculosis and multifocal involvement of cutaneous tuberculosis is an even rarer manifestation. We report one such case of multifocal tuberculosis verrucosa cutis in a 17-year old male patient in the absence of any primary tuberculous focus.
  4,338 86 6
ORIGINAL ARTICLES
Uric acid : A new antioxidant in patients with pemphigus vulgaris
Maryam Yousefi, Hoda Rahimi, Behrooz Barikbin, Parviz Toossi, Sara Lotfi, Mehdi Hedayati, Shima Younespour
May-June 2011, 56(3):278-281
DOI:10.4103/0019-5154.82480  PMID:21772587
Background: Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, for example, atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus, and alopecia areata. ROS has an important role in the inflammation process. In PV, increased production of ROS leads to decline of antioxidants in plasma and red blood cells which results in oxidative stress. We aimed to evaluate the level of these antioxidants in PV patients and compare it to the controls. Materials and Methods: Among patients attending the dermatology clinics, 30 patients with PV, who had never been on treatment, were enrolled to the study. The control group consisted of 30 age- and sex-matched healthy non-smoker individuals. Venous blood was collected from the subjects for the evaluation of plasma levels of glutathione peroxidase, vitamin C, selenium, bilirubin, and uric acid. Results: Age mean and standard deviation of the patients (40.83, 12.74) was comparable to the controls (41.96, 13.08). Mean level of uric acid was significantly lower in PV patients compared to the controls (P = 0.006). Other antioxidants were not different between the two groups. Uric acid of the patients with mucosal involvement was significantly lower than patients with mucocutaneous involvement (P = 0.049). Limitations: The blood level of other antioxidants (e.g. malondialdehyde) was not evaluated. Conclusions: Uric acid as an antioxidant in our study had similar changes to previous studies in the field of other diseases but selenium, bilirubin, and glutathione peroxidase did not differ between patients and controls.
  4,177 151 10
CORRESPONDENCE
Pyoderma gangrenosum: Variation in clinical presentation at different ages
Banavasi S Girisha, Manjunath M Shenoy, Michelle Mathias, Vijaya Shenoy
May-June 2011, 56(3):355-357
DOI:10.4103/0019-5154.82494  PMID:21772616
  4,013 119 1
CASE REPORTS
Cytophagic histiocytic panniculitis: Report of two cases
Jayasree Manoj, Feroze Kaliyadan, Manoj Unni, AD Dharmaratnam
May-June 2011, 56(3):306-308
DOI:10.4103/0019-5154.82487  PMID:21772594
Cytophagic histiocytic panniculitis (CHP) was first described in 1980 by Winkelmann as a chronic histiocytic disease of the subcutaneous adipose tissue, which is characterized clinically by tender erythematous nodules, recurrent high fever, malaise, jaundice, organomegaly, serosal effusions, pancytopenia, hepatic dysfunction, and coagulatory abnormalities. CHP may occur either isolated or as part of cutaneous manifestations of hemophagocytic syndrome. Here, we report two different presentations of CHP.
  4,018 65 -
CORRESPONDENCE
Use of topical povidone-iodine resulting in a iododerma
Zerrin Ogretmen, Serhat Sari, Murat Ermete
May-June 2011, 56(3):346-347
DOI:10.4103/0019-5154.82508  PMID:21772610
  3,787 55 3
Cytogenetics: A new tool for early diagnosis and prognosis of tuberous sclerosis?
Ashish Singh, S Ambujam, AN Uma
May-June 2011, 56(3):347-349
DOI:10.4103/0019-5154.82507  PMID:21772611
  3,751 68 -
Sudden onset purpura in a healthy infant: Acute hemorrhagic EDEMA of infancy
Sheena Bansal, Smita Ghate, Hemangi R Jerajani
May-June 2011, 56(3):349-351
DOI:10.4103/0019-5154.82504  PMID:21772612
  3,747 52 1
SHORT COMMUNICATIONS
Experimental dermatological surgery: An animal model for developing skills with dermal fillers
Juliana Catucci Boza, Vanessa Santos Cunha, Claudia Dickel de Andrade, Isabel Cristina Palma Kuhl
May-June 2011, 56(3):303-305
DOI:10.4103/0019-5154.82486  PMID:21772593
The importance of laboratory experiments in the formation of physicians is well recognized since they facilitate scientific development and enhance technical skills. Dermal filling procedures are performed for the correction of wrinkles, rhytids, scars, and lipodystrophy. Till date, experimental models for the training of dermal filling techniques have not been studied. To demonstrate an experimental laboratory model for the training of dermal filling techniques in an animal model. The heads of pigs were used for this purpose, together with Carbopol gel at different densities, which was used to simulate the fillers available in the market. Needles and specific cannulas were used to apply the fillers into the creases and other areas of the pig skin. The pig head appears to be a suitable model for this training. Carbopol gel is a good choice for simulating fillers. This model of laboratory experiment requires a minimum of infrastructure; it is a low-cost alternative and facilitates practical training in the application of dermal fillers.
  3,394 62 1
CASE REPORTS
Fibromatosis of breast mimicking sarcoidosis
Silonie Sachdeva
May-June 2011, 56(3):313-314
DOI:10.4103/0019-5154.82489  PMID:21772596
Primary mammary fibromatosis is a rare skin condition which can arise after trauma or previous surgery. The exact etiology is unknown. Very few cases have been reported in literature and the main emphasis is to differentiate this condition from breast carcinoma. We report here an unusual case of a 60 year old female who presented with skin lesion which clinically looked sarcoid with history suggestive of sarcoidosis, but on histopathology fibromatosis of breast was revealed. Complete work up ruled out any carcinomatous changes. Surgical excision of the lesion was done with no recurrence seen in one year follow up period.
  3,328 47 -
SHORT COMMUNICATIONS
Iron therapy in hand eczema: A new approach for management
Ashimav Deb Sharma
May-June 2011, 56(3):295-299
DOI:10.4103/0019-5154.82484  PMID:21772591
It is observed that adequate iron intake and status can limit nickel absorption from the diet in the human body. Chronic vesicular hand eczema (CVHE) due to nickel sensitivity is a common dermatological condition where the dietary nickel acts as a provocating factor. Such patients are usually treated with low nickel diet (LND). The present study was conducted to observe the result of addition of oral iron with LND in the treatment of CVHE in patients due to nickel sensitivity. 23 patients with CVHE due to nickel sensitivity were taken for this study. Study group (12 patients) were advised LND with oral iron for a period of 12 weeks. Control group (11 patients) were advised LND alone for a period of 12 weeks. Fast improvement noted in the skin lesions of the study group patients; 10 (83.33%) patients had complete clearance of their hand eczemas at the end of 12 weeks. There were significant reductions in the blood level of nickel in those patients. Moderate improvement noted in the skin lesions of the control group patients; 5 (45.45%) patients showed complete clearance of hand eczema at the end of 12 weeks. This study showed that oral iron helped to reduce nickel absorption from the diet. The study also showed that combination of LND and oral iron can bring a faster reduction in the severity of clinical symptoms of CVHE in a nickel sensitive individual.
  3,182 158 -
BASIC RESEARCH
Genetic variations in NALP1 MRNA expressions in human vitiligo
Sudha S Deo, Ameya R Bhagat, Rajnikant N Shah
May-June 2011, 56(3):266-271
DOI:10.4103/0019-5154.82478  PMID:21772585
Introduction: Vitiligo is an acquired autoimmune disease of unknown etiology showing depigmentation of the skin due to the absence of melanocytes. Familial vitiligo suggests a genetic origin to this disease. Chromosome 17 was recently demonstrated to harbor the gene coding for NALP1. Patients and Methods: A total of 18 patients of vitiligo were selected on the basis of clinical history. Group 1 (N=8) showing segmental or localized vitiligo with one or two macules on the body. Group 2 (N=10) with generalized or whole body vitiligo. A control group of 10 healthy individuals were selected from our laboratory persons with no history or any infections or skin disease. NALP1 gene expression was studied using RT-PCR assay and the bands quantitated as intensity using volume as measurement and comparison of results was done using SPSS 16 version for statistical analysis. NALP1 gene expression was observed in vitiligo patients with different intensities. Results: Greater reduction in the intensity was seen in Group I, which was inversely proportional to the volume of the band. The intensity of the NALP1 and the GAPDH gene expression was more in Group 2 patients than that shown by Group 1. Conclusion: This study shows expression of NALP1 gene in patients as well as normals. NALP1 is widely expressed at low levels but is expressed at high levels in immune cells, particularly T cells and Langerhans cells, in which different patterns are seen that are consistent with the particular involvement of NALP1 in skin autoimmunity.
  3,024 77 4
Association of cytokine gene polymorphisms with psoriasis in cases from the Nile Delta of Egypt
Ahmad A Settin, Hanaa A Hassan, Rizk A El-Baz, Tahia A Hassan
May-June 2011, 56(3):272-277
DOI:10.4103/0019-5154.82479  PMID:21772586
Background: Psoriasis is a chronic inflammatory skin disease with an immunogenetic background. This work was planned to check for the association of polymorphisms related to cytokine genes TNF-α-308 (G/A), IL-10 -1082 (G/A), IL-6 -174 (G/C), and IL-1Ra (VNTR) with psoriasis in cases from Egypt. Materials and Methods: This work included 46 cases with psoriasis recruited from the Dermatology Departments, University Hospitals, Nile Delta region of Egypt. They included 14 males and 32 females with an age mean ± SD of 46.68 ± 12.16 years and range of 15-70 years. Their genotypes were compared to 98 healthy controls of matched age and sex from the same locality. Genotyping was done through deoxyribonucleic acid amplification using PCR with sequence specific primers for polymorphic alleles. Results: Compared to controls, cases showed significant higher frequency of certain genotypes including IL-6 -174 CC (P < 0.001, OR = 6.7), IL-10 -1082 GG ( P < 0.05, OR = 5.1), and TNF-α-308 GG ( P < 0.05, OR = 3.7). TNF-α-308 GG and IL-10 -1082 GG genotypes were higher among cases with plaque subtype of moderate severity. Combined heterozygosity for IL-10 GA, IL-6 GC with TNF GA showed a significant low frequency among studied cases. Conclusion: Genetic polymorphisms related to IL6, IL10, and TNF-α genes showed a particular pattern of association with psoriasis that may have a potential impact on disease counseling and management.
  2,974 67 5
CORRESPONDENCE
Late onset calcification following juvenile dermatomyositis: Response with weekly alendronate
Feroze Kaliyadan, S Venkitakrishnan
May-June 2011, 56(3):357-359
DOI:10.4103/0019-5154.82491  PMID:21772617
  2,769 60 -
Childhood multicentric lupus vulgaris
Sundaram Murugan, TP Vetrichevvel, Shobana Subramanyam, Anandan Subramanian
May-June 2011, 56(3):343-344
DOI:10.4103/0019-5154.82510  PMID:21772608
  2,642 64 -
CASE REPORTS
Fusarium soloni mycetoma
VJ Katkar, Supriya S Tankhiwale, Arvind Kurhade
May-June 2011, 56(3):315-317
DOI:10.4103/0019-5154.82490  PMID:21772597
A young apparently healthy, non-diabetic, HIV non-reactive woman presented with a mycetoma-like lesion on right buttock. Discharge was scanty, and mycotic grains were not seen. Biopsy of sinus track was obtained for microscopy and culture. Microscopic examination revealed plenty of fungal hyphae in direct microscopic examination of grounded tissues in saline; KOH, Gram's, and H and E-stained smears. All the three inoculated slants of Sabouraud's media yielded heavy growth of Fusarium solani. Presence of numerous hyphal fragments in direct microscopy and heavy growth of F. solani in all three slants indicative of etiological role of fungus in the present case. It is probably a first report of F. soloni mycetoma from India.
  2,602 76 3
CORRESPONDENCE
Bowen's disease on palm: A rare presentation
Manoj Harnalikar, Atul Dongre, Uday Khopkar
May-June 2011, 56(3):353-354
DOI:10.4103/0019-5154.82497  PMID:21772615
  2,602 61 1
PHOTO QUIZ
Asymptomatic papules and plaque in a patient with generalized vitiligo
IS Reddy, G Swarnalatha, Meenakshi Swain
May-June 2011, 56(3):341-342
DOI:10.4103/0019-5154.82506  PMID:21772607
  2,378 84 -
CORRESPONDENCE
Imatinib induced lichen planus
R Sudha, TP Vetrichevvel, K Krishnarathnam, S Anandan
May-June 2011, 56(3):351-352
DOI:10.4103/0019-5154.82502  PMID:21772613
  2,142 69 1
Bullous aplasia cutis congenita: Is HIV an association?
Arun Kumar Metta, S Ramachandra, Shilpa Manupati
May-June 2011, 56(3):344-345
DOI:10.4103/0019-5154.82509  PMID:21772609
  1,786 47 -
Autologous serum skin test in various dilutions
Kiran V Godse
May-June 2011, 56(3):352-353
DOI:10.4103/0019-5154.82499  PMID:21772614
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