This article traces the history of the growth and development of our National Leprosy Eradication Programme (NLEP). The aims, strategy, means of eradication, the organizational structure have been discussed. Since the beginning of this programme, the prevalence rate and disability rate have shown a sharp decline. The number of cases detected and under treatment have also increased. The achievement made has been possible due to an excellent organization of leprosy relief work under NLEP with the active cooperation of the non- governmental organizations. Now that leprosy is on the decline, the need of education and rehabilitation of patients assumes a greater importance.

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A young woman of 24 with personal and family history of atopy development pruritus vulva each time after sexual intercourse with her husband. History of urticaria of sites of contact with semen on her thighs gave suspicion of contact urticaria. Positive wheal and flare response to pin prick test with semen, excellent therapeutic response to topical steroid and oral Cetirizine and non- recurrence of the problem after using condom by her husband confirmed the diagnosis of semen allergy.

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Automobile repair workers are at risk of developing skin morbidity including occupational dermatoses because of their exposure to mineral oils, petroleum products and its derivatives and lubricating oil. This cross- sectional study was carried out at Maharashtra State Road Transport Corporation workshops in Nagpur city to investigate prevalence of skin morbidity including contact dermatitis in automobile repair workers. The study included 288 (49.9%) automobile repair workers 180 (31.3%) workshop office staff and 109 (18.8%) divisional office employees. Dermatitis was the commonest skin morbidity in all the study subjects and it was significantly more prevalent in automobile repair workers. Folliculitis was detected in 13.2% of auto – repair workers and was not seen in the other two groups. Increasing trend of skin morbidity was correlated with the length of service of employees. Proper protective measures along with suitable washing facilities should be provided

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A 50 year old woman presented with an ulceroproliferative mass in the value of 4 month duration. Biopsy of the lesion showed features of a basisquamous cell carcinoma. This is a rare tumour showing histopathological features of both basal cell and squamous cell carcinomas. The clinical, histopathological and histogenetic status of this tumour are discussed.

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A clinico- pathological study of 28 cases of ichthyosis vulgaris appeared with in the age of 5 years. The presence of the disease since birth was also found. While most (24) patients showed a diminution of severity in summer with an aggravation during winter, 4 patients followed the opposite seasonal pattern. Only in 4 patients, fine scales in the scalp were detected. One patient showed an affection of flexures. There was also a low occurrence of palmo- planter hyperkeratosis, follicular keratosis, fissuring of hands and feet and atopy.

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While surgically treating vitiligo by autologous punch grafts, spontaneous re-pigmentation was observed incidentally on patches other than the grafted sites. Based on this observation, the study was undertaken to see the effect of the grafts on re-pigmentation of other patches. Twenty patients with sixty-seven patches of stable and refractory vitiligo of 2 –16 yr duration constituted the study group. The patients were followed up for 10 months. Spontaneous re-pigmentation occurred in 23 sites of 8 patients. The patches started re-pigmenting spontaneously at the time of initiation of the perigraft pigment spread. The rate and extent of spontaneous re-pigmentation were more compared to the perigraft pigment spread. The study inspired us to search for the unknown stimulation of the yet- silent melanocytes becoming active after the surgical procedure.

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A case of confluent and reticulated papillomatosis with classical flexual pigmented papules distributed in reticular pattern is described. Patient responded well to a one- month course of Fluconazole therapy.

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Leishmaniasis is a group of diseases caused by several species of the genus leishmania. It is not prevalent in Kerala even though there are a few case reports. Recently, a focus of indigenous leishmaniasis is located in the north- east part of Kerala. We are also reporting probably indigenous cases along with those contracted from Middle- east countries.

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A 38 year old woman developed dermatomyositis after radical mastectomy and tamoxifen therapy for metastatic breast carcinoma. The possibility of the drug as the underlying cause of the connective tissue disease is discussed.

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A 36 year old female suddenly observed crops of multiple, bilateral symmetrical, well defined, tender, erythematous nodules which healed with bruise- like colour changes. Simultaneously she developed bilateral symmetrical arthritis with acute swelling of ankle joints and feet. She also had low grade fever and one almond size, non- tender, firm, freely mobile lymph node on the left side of neck. X-ray chest revealed hilar lymphadenopathy. ESR was 72 mm. Serum calcium was 8.5 g% Le cell phenomenon and RF were negative. Mantoux test was positive. Patient was put on anti-tubercular treatment without any improvement. Patient was given Dapsone 150 mg OD, Cap, Zevit and Tab. Flexon BD and steady improvement started after 7 days and all the lesions healed by 2 months of Dapsone therapy.

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A 35 year old female developed pemphigus foliaceus for the first time during her second pregnancy. Ultrasonogram done at the hospital had revealed a single live fetus of 28 weeks. But the pregnancy terminated in premature labour and still birth. Baby apparently did not have any skin lesion but was not available for examination or investigation.

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A 40 year old female presented with erythematous infiltrating plaque on the face involving both the ears with destruction of nasal cartilage and satellite lesions on the right shoulder. Clinical diagnosis of Hansen’s disease was later proved to be a case of Lupus vulgaris.

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A young male patient of SLE developed bullous lesions. Histopathology and DIF were consistent with the diagnosis of bullous SLE.

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A 43 year old female had progressive indolent, firm, tender, nodular swellings with multiple sinuses discharging pus containing black granules on left foot and ankle since 3 years. Smear of granule showed dark brown irregular mass with hyphae towards the periphery. Superimposed E. coli infection was treated with cefadroxyl 500 mg B.D Histopathologically marked acanthosis of epidermis , dense collection of mononuclear PMNL’s, plasma cells around granules of maduramycosis were seen. X-ray foor showed osteolytic lesions and culture was negative. Satisfactory and progressive improvement occurred after 7 weeks of therapy with ketoconozole 200 mg.

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A rare disorder of periodic Peeling Skin Syndrome, encountered in an adult male in a tropical skin clinic in Chennai, is reported along with its histopathological features.

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Oral pigmentation occurs in Peutz-Jeghers syndrome, Addison’s disease, melanocytic nevi and fixed drug eruption. We report a case of oral pigmentation; biopsy revealed focal melanosis which was confirmed by Fontana – Masson stain. The present series in a family with oral pigmentation suggests autosomal dominant pattern of inheritance. It is imperative to exclude all other causes of oral pigmentation before diagnosing familial oral pigmentation.

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A neonate with a unique congenital mechanobullous disorder (Bart’s syndrome) is described and compared with similar patterns from the literature. The blisters were sub epidermal, remitted within a few months and have not recurred on long- term follow – up. The relation of Bart’s syndrome to epidermolysis bullosa is unclear.

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Trauma associated with break in continuity of skin results in inocalation of M. leprae at the site of injury with resultant development of inoculation leprosy. The present report records a case of inoculation leprosy after ear-piercing in a 45 year old female with positive smears and borderline lepromatous histopathology, due most probably to systematic steroids.

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A 57 year old man had a cauliflower growth over his right sole for 2 years. Biopsy revealed pseudoepitheliomatous changes with no evidence of malignancy. Chemical cautery with trichloroacetic acid and salicylic acid was un satisfactory

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A 45 year old male presented with classical clinico- pathological mycosis fungoides. He had a prolonged phase of premycotic eruption closely simulating psoriasis. As expected, the patient died of systemic involvement in 2 years in spite of chemotherapy.

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The clinical and histological findings of a three and a half year old female child with continuous non- seasonal peeling of skin since the age of seven months is described.

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An 18 year old girl presented with multiple, painful, non- healing ulcers over the lower extremities of 2 month duration. The lesions had started as hemorrhagic bullae which broke down leaving ulcers. The features were consistent with those of pyoderma gangrenosum. Patients did not have any associated disease including myeloproliferative disorder. Ulcer healed with systemic steroids.

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A case of a 32 year old female having acrokeratosis verruciformis is reported. The lesions responded partially to topical vitamin A acid (tretinoin)

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A 35 years old man presented with features of epidermolysis bullosa acquisita. Here is the case report.

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A case of cutaneous rhinosporidiosis mimicking verucca vulgaris involving an eyelid in a young male patient is described.

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A case of Cronkhite- Canada syndrome in a 59 year old male is reported. The patient presented with generalized hyper pigmentation, alopecia, loss of finger and toenails, diarrhoea, weight loss and gastro- intestinal polyposis. The case is reported for its rare presentation as the ectodermal changes preceded other clinical features.

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A 53 years old male had a 3 year long history of multiple subcutaneous nodules distributed all over the body. Although no neurological manifestations were present, CT- scan demonstrated multiple cerebral lesions. Skin biopsy showed subcutaneous cysticerci.

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