Indian Journal of Dermatology
ORIGINAL ARTICLE
Year
: 2020  |  Volume : 65  |  Issue : 4  |  Page : 274--278

Clinical features, risk factors, and prognostic markers of drug-induced liver injury in patients with stevens-johnson syndrome/toxic epidermal necrolysis


Zhibin Zhang1, Sisi Li1, Zhixiong Zhang2, Kaihui Yu3, Xunxin Duan4, Lin Long5, Shulan Zhang1, Meiying Jiang1, Ougen Liu1 
1 Department of Dermatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
2 Department of Biology, Taiyuan Normal University, Taiyuan, Shanxi, China
3 Medical Department of Graduate School, Nanchang University, Nanchang, China
4 Department of Laboratory, The Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China
5 Department of Hepatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China

Correspondence Address:
Ougen Liu
Department of Dermatology, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, Jiangxi, 330006
China

Background: The liver and skin are the most common organs involved in Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Drug reactions rarely affect both organs concurrently. The clinical features, risk factors, and prognostic markers of drug-induced liver injury (DILI) in patients with SJS/TEN are not well studied. Materials and Methods: The clinical features, risk factors, and prognostic markers of DILI in patients with SJS/TEN hospitalized at the dermatology department of our hospital from January 2009 to December 2018 were retrospectively analyzed. Results: A total of 298 patients with SJS/TEN were enrolled in this study. Of them, 40 had liver injury and the rest served as control. Causative drugs mainly included antipodagrics (xanthine oxidase inhibitors occupying 100% among antipodagrics), anticonvulsants (dibenzazepine occupying 76.92% among anticonvulsants), and traditional Chinese medicines. There was a statistically significant difference between the patients with liver injury and the control group in the history of liver disease, diabetes, and hyperlipidemia (P < 0.05). Nine of the 40 patients with liver injury died. High serum total bilirubin and creatinine levels were significantly associated with poor prognosis of DILI in patients with SJS/TEN (P < 0.05). Conclusion: DILI usually occurs in patients with SJS/TEN. Pre-existing liver disease, diabetes, and hyperlipidemia are independent risk factors for DILI in patients with SJS/TEN. High serum total bilirubin and creatinine levels may be useful prognostic markers for DILI in patients with SJS/TEN.


How to cite this article:
Zhang Z, Li S, Zhang Z, Yu K, Duan X, Long L, Zhang S, Jiang M, Liu O. Clinical features, risk factors, and prognostic markers of drug-induced liver injury in patients with stevens-johnson syndrome/toxic epidermal necrolysis.Indian J Dermatol 2020;65:274-278


How to cite this URL:
Zhang Z, Li S, Zhang Z, Yu K, Duan X, Long L, Zhang S, Jiang M, Liu O. Clinical features, risk factors, and prognostic markers of drug-induced liver injury in patients with stevens-johnson syndrome/toxic epidermal necrolysis. Indian J Dermatol [serial online] 2020 [cited 2021 Oct 26 ];65:274-278
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2020;volume=65;issue=4;spage=274;epage=278;aulast=Zhang;type=0