Indian Journal of Dermatology
ORIGINAL ARTICLE
Year
: 2020  |  Volume : 65  |  Issue : 4  |  Page : 265--268

Correlation of buccal micronucleus with disease activity score using buccal micronucleus cytome analysis (BMCA) in systemic lupus erythematosus


Khalil Assiri1, Mohammad Shahul Hameed1, Ali Azhar Dawasaz1, Eman Alamoudi1, Alhussain Mohammad Asiri2, Hitesh Vij3, Muhammed Ajmal1 
1 Department of Diagnostic Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia
2 Department of Rheumatology, Asir Central Hospital, Abha, Kingdom of Saudi Arabia
3 Boston University Henry M. Goldman School of Dental Medicine, Boston, USA

Correspondence Address:
Mohammad Shahul Hameed
Department of Diagnostic Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha
Kingdom of Saudi Arabia

Background: A disease activity score obtained by using systemic lupus erythematosus disease activity index (SLEDAI) has traditionally been a reliable method to assess the SLE status of patients. More recently, a buccal micronucleus cytome assay (BMCA) has been developed for use as a biomarker of DNA damage in patients with SLE. There has been a very limited number of studies pertaining to the oral lesions in Arab population suffering from SLE in Asir region. Hence, it became utmost important to study epidemiological data of oral mucosal lesions in SLE patients. Distribution of oral lesions in SLE patients could also be helpful in better management of oral complications. Aim: The aim of this study was to determine the existence of a correlation between SLEDAI score and the degree of micronuclei (MN) formation using BMCA. Materials and Methods: After thorough oral examination of adult Saudi SLE patients of Asir hospital and that of healthy control subjects, the subjects underwent BMCA from normal unaffected bilateral buccal mucosae. Results: Pearson's correlation test showed that MN count did not significantly correlate with either disease activity or duration of SLE. Conclusions: Controlled state SLE does not lead to a significant increase in MN formation. Thus, the occurrence of premalignant lesions in the oral cavity could be minimized using proper management protocols.


How to cite this article:
Assiri K, Hameed MS, Dawasaz AA, Alamoudi E, Asiri AM, Vij H, Ajmal M. Correlation of buccal micronucleus with disease activity score using buccal micronucleus cytome analysis (BMCA) in systemic lupus erythematosus.Indian J Dermatol 2020;65:265-268


How to cite this URL:
Assiri K, Hameed MS, Dawasaz AA, Alamoudi E, Asiri AM, Vij H, Ajmal M. Correlation of buccal micronucleus with disease activity score using buccal micronucleus cytome analysis (BMCA) in systemic lupus erythematosus. Indian J Dermatol [serial online] 2020 [cited 2021 Oct 16 ];65:265-268
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2020;volume=65;issue=4;spage=265;epage=268;aulast=Assiri;type=0