Indian Journal of Dermatology
E-IJD«-SHORT COMMUNICATION
Year
: 2019  |  Volume : 64  |  Issue : 3  |  Page : 250-

Effective healing of leprosy chronic plantar ulcers by application of human amniotic membrane stem cell secretome gel


FR Natallya1, N Herwanto2, C RS Prakoeswa2, DM Indramaya2, FA Rantam3 
1 Clinical Department, Faculty of Medicine, Universitas Surabaya (UBAYA), Surabaya, Indonesia
2 Department of Dermato-Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia
3 Stem Cell Research and Development Center; Virology and Immunology Laboratory, Department of Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia

Correspondence Address:
Dr. C RS Prakoeswa
Department of Dermato-Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Teaching Hospital, Surabaya
Indonesia

Background: Chronic plantar ulcers are common problems for leprosy patients with numb feet due to their prolonged healing time. Chronic plantar ulcers affect the quality of life of patients and can lead to more serious complications, such as disability and deformity, if not handled appropriately. Wound-care products in the market, however, give unsatisfactory results. One factor in the delayed healing of chronic plantar ulcers due to leprosy is the lack of growth factors and cytokines in the wound due to reduced blood supply. We speculated that application of human amniotic membrane stem cellá(hAMSC) secretome, which contains growth factors and cytokines, could improve wound healing. Aim: To evaluate the effect of topical application of a hAMSC secretome gel on wound healing of chronic plantar ulcers due to leprosy. Materials and Methods: We recruited 11ápatients after leprosy treatment with chronic plantar ulcers due to leprosy. hAMSC secretome gel was applied topically to ulcers every 3ádays for up to 2ámonths. Ulcer size and possible side effects or complications from gel application were evaluated weekly. Results: The ulcers of 8 of 11ápatientsá(72.7%) completely healed, the ulcers of 2ápatientsá(18.2%) partially healed, and the ulcers of 1ápatientá(9.1%) persisted. No ulcers became worse. Conclusion: hAMSC secretome was found to be an efficacious and well-tolerated alternative therapy for chronic plantar ulcers due to leprosy.


How to cite this article:
Natallya F R, Herwanto N, Prakoeswa C R, Indramaya D M, Rantam F A. Effective healing of leprosy chronic plantar ulcers by application of human amniotic membrane stem cell secretome gel.Indian J Dermatol 2019;64:250-250


How to cite this URL:
Natallya F R, Herwanto N, Prakoeswa C R, Indramaya D M, Rantam F A. Effective healing of leprosy chronic plantar ulcers by application of human amniotic membrane stem cell secretome gel. Indian J Dermatol [serial online] 2019 [cited 2021 Nov 28 ];64:250-250
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2019;volume=64;issue=3;spage=250;epage=250;aulast=Natallya;type=0