Indian Journal of Dermatology
SHORT COMMUNICATION
Year
: 2019  |  Volume : 64  |  Issue : 1  |  Page : 41--46

Expression of cluster of differentiation 1a-positive langerhans cells in oral lichen planus


Thankanadar Arul Kumar1, Veeran Veeravarmal1, Ramdas Madhavan Nirmal1, Ramamoorthy Amsaveni1, Mohamed Hanifa Mohamed Nassar1, Ganesan Kesavan2 
1 Department of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India
2 Department of Oral Pathology, Madha Dental College and Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Veeran Veeravarmal
Department of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu
India

Background/Purpose: Lichen planus is a T-cell-mediated mucocutaneous disorder characterized histopathologically by a band of chronic inflammatory cells in the subepithelial zone and degeneration of basal layer. The present study was aimed to evaluate the distribution and quantitative assessment of cluster of differentiation 1a (CD1a)-positive Langerhans cells (LCs) in oral lichen planus (OLP), thus to determine the role of LCs pertaining to the changes occurring in OLP. Materials and Methods: Five cases of normal oral mucosa and 20 cases of OLP were immunostained with CD1a antibody; the positive cells were counted manually in the photomicrographs and statistically analyzed using t-test, Mann–Whitney test, and Wilcoxon signed-rank test. Results: The average percentage of CD1a-positive LCs in normal subjects was 0.9%, and in the OLP cases higher percentage was observed (3.93%). The statistical comparison of these two parameters was significant (P =0.018). The degree of basal cell degeneration and density of subepithelial infiltrate on statistical comparison with the concentration of CD1a-positive LCs showed significant results. Conclusion: LCs play a pivotal role in the recruitment of CD4+ and CD8+ cells to the subepithelial region and basal keratinocytes apoptosis. A small number of study subjects, assessment of only CD1a molecule and LCs in the epidermis only were a few of the drawbacks of the study.


How to cite this article:
Kumar TA, Veeravarmal V, Nirmal RM, Amsaveni R, Nassar MH, Kesavan G. Expression of cluster of differentiation 1a-positive langerhans cells in oral lichen planus.Indian J Dermatol 2019;64:41-46


How to cite this URL:
Kumar TA, Veeravarmal V, Nirmal RM, Amsaveni R, Nassar MH, Kesavan G. Expression of cluster of differentiation 1a-positive langerhans cells in oral lichen planus. Indian J Dermatol [serial online] 2019 [cited 2022 Jan 26 ];64:41-46
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2019;volume=64;issue=1;spage=41;epage=46;aulast=Kumar;type=0