Indian Journal of Dermatology
BASIC RESEARCH
Year
: 2011  |  Volume : 56  |  Issue : 1  |  Page : 14--18

Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1


Dongliang Zhang, Lijuan Gu, Jingjie Li, Zheng Li, Chunyan Wang, Zhen Wang, Lei Liu, Mira Li, Changkeun Sung 
 Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764, Korea

Correspondence Address:
Changkeun Sung
Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejeon 305-764
Korea

Background: Hair loss is seen as an irreversible process. Most research concentrates on how to elongate the anagen, reduce the negative factors of obstructing hair growth and improve the hair number and size. Aim: In our experiment, we tried to prove that the cow placenta extract can promote hair growth by elongating hair shaft and increasing hair follicle number. Materials and Methods: Cow placenta extract (CPE), water and minoxidil applied separately on the back of depilated B57CL/6 mice for the case, negative and positive control respectively. We checked the proliferation of cells which are resident in hair sheath, and the expression of a few growth factors which stimulate hair growth. Results: Result shows that placenta extract more efficiently accelerates cell division and growth factor expression, by raising the insulin-like growth factor (IGF-1) mRNA and protein level to increase HF size and hair length. Conclusions: The extract is not a purified product; so, it is less effective than minoxidil, which is approved by the US FDA for the treatment of male pattern baldness. If refinement is done, the placenta extract would be a good candidate medicine for hair loss.


How to cite this article:
Zhang D, Gu L, Li J, Li Z, Wang C, Wang Z, Liu L, Li M, Sung C. Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1.Indian J Dermatol 2011;56:14-18


How to cite this URL:
Zhang D, Gu L, Li J, Li Z, Wang C, Wang Z, Liu L, Li M, Sung C. Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1. Indian J Dermatol [serial online] 2011 [cited 2022 Jan 29 ];56:14-18
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=1;spage=14;epage=18;aulast=Zhang;type=0