Indian Journal of Dermatology
SHORT COMMUNICATION
Year
: 2010  |  Volume : 55  |  Issue : 2  |  Page : 198--199

A meta-analysis comparing efficacy of continuous terbinafine with intermittent itraconazole for toenail onychomycosis


NA Trivedi, PC Shah 
 Department of Pharmacology, Govt. Medical College, Baroda, Gujarat, India

Correspondence Address:
N A Trivedi
Department of Pharmacology, Govt. Medical College, Baroda, Gujarat
India

Background: Toenail onychomycosis is a challenge for clinicians to treat. While both Itraconazole and terbinafine have proven to be effective against onychomycosis, very little is known about their comparative efficacy in achieving mycological and clinical cure. Aim: The purpose of this meta-analysis is to compare the efficacy of continuous terbinafine with intermittent itraconazole in the treatment of toenail onychomycosis. Material and Methods: all RCTs comparing continuous terbinafine with intermittent itraconazole were identified from PUBMED and BIDS electronic database. Results: analysis of total eight trials including 1181 patients state that treatment with continuous terbinafine is more likely to produce mycological and clinical cure compared to intermittent itraconazole with odds ratio 2.3(95% CI, 1.7 to 3.0 P<0.0001) Conclusion: though both itraconazole and terbinafine are well tolerated and highly effective drugs, continuous terbinafine is more effective than intermittent itraconazole at achieving mycological cure of toenail onychomycosis


How to cite this article:
Trivedi N A, Shah P C. A meta-analysis comparing efficacy of continuous terbinafine with intermittent itraconazole for toenail onychomycosis.Indian J Dermatol 2010;55:198-199


How to cite this URL:
Trivedi N A, Shah P C. A meta-analysis comparing efficacy of continuous terbinafine with intermittent itraconazole for toenail onychomycosis. Indian J Dermatol [serial online] 2010 [cited 2021 Jan 25 ];55:198-199
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2010;volume=55;issue=2;spage=198;epage=199;aulast=Trivedi;type=0