Indian Journal of Dermatology
IJD SYMPOSIUM
Year
: 2010  |  Volume : 55  |  Issue : 2  |  Page : 161--170

Biological therapy of psoriasis


Raja K Sivamani1, Genevieve Correa3, Yoko Ono3, Michael P Bowen3, Siba P Raychaudhuri2, Emanual Maverakis3 
1 Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817
2 Veterans Affairs Northern California Health Care System, Sacramento, CA 95655; Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Sacramento, CA 95817
3 Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817; Veterans Affairs Northern California Health Care System, Sacramento, CA 95655

Correspondence Address:
Emanual Maverakis
3301 C Street Suite 1400, Sacramento CA 95816

The treatment of psoriasis has undergone a revolution with the advent of biologic therapies, including infliximab, etanercept, adalimumab, efalizumab, and alefacept. These medications are designed to target specific components of the immune system and are a major technological advancement over traditional immunosuppressive medications. These usually being well tolerated are being found useful in a growing number of immune-mediated diseases, psoriasis being just one example. The newest biologic, ustekinumab, is directed against the p40 subunit of the IL-12 and IL-23 cytokines. It has provided a new avenue of therapy for an array of T-cell-mediated diseases. Biologics are generally safe; however, there has been concern over the risk of lymphoma with use of these agents. All anti-TNF-α agents have been associated with a variety of serious and DQroutineDQ opportunistic infections.


How to cite this article:
Sivamani RK, Correa G, Ono Y, Bowen MP, Raychaudhuri SP, Maverakis E. Biological therapy of psoriasis.Indian J Dermatol 2010;55:161-170


How to cite this URL:
Sivamani RK, Correa G, Ono Y, Bowen MP, Raychaudhuri SP, Maverakis E. Biological therapy of psoriasis. Indian J Dermatol [serial online] 2010 [cited 2021 Jan 17 ];55:161-170
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2010;volume=55;issue=2;spage=161;epage=170;aulast=Sivamani;type=0