Indian Journal of Dermatology
: 2010  |  Volume : 55  |  Issue : 2  |  Page : 144--147

Intensive treatment of leg lymphedema

Jose Maria Pereira de Godoy1, Lina M.O Azoubel2, Maria de Fatima Guerreiro de Godoy3,  
1 Department of Cardiology and Cardiovascular Surgery and professor of the post graduation course of Medicine School of São Jose do Rio Preto-FAMERP, Brazil
2 Nutritionist of the Godoy Clinic and Professor of the Post Graduation Course on Rehabilitation of Lymphevenous in Medicine School in São José do Rio Preto-FAMERP-Brazil of São Jose do Rio Preto, Brazil
3 Occupational Therapist, Professor of the Post Graduation course on Lymphovenous Rehabilitation - FAMERP and Clinic Godoy, São José do Rio Preto, Research Capes, Brazil

Correspondence Address:
Jose Maria Pereira de Godoy
Rua Floriano Peixoto, 2950. São José do Rio Preto, SP - 15010-020


Background: Despite of all the problems caused by lymphedema, this disease continues to affect millions of people worldwide. Thus, the identification of the most efficacious forms of treatment is necessary. Aim: The aim of this study was to evaluate a novel intensive outpatient treatment for leg lymphedema. Methods: Twenty-three legs of 19 patients were evaluated in a prospective randomized study. The inclusion criteria were patients with Grade II and III lymphedema, where the difference, measured by volumetry, between the affected limb below the knee and the healthy limb was greater than 1.5 kg. Intensive treatment was carried out for 6- to 8-h sessions in the outpatient clinic. Analysis of variance was utilized for statistical analysis with an alpha error of 5% (P-value <0.05) being considered significant. Results: All limbs had significant reductions in size with the final mean loss being 81.1% of the volume of edema. The greatest losses occurred in the first week (P-value <0.001). Losses of more than 90% of the lymphedema occurred in 9 (39.13%) patients; losses of more than 80% in 13 (56.52%), losses of more than 70% in 17 (73.91%) and losses of more than 50% were recorded for 95.65% of the patients; only 1 patient lost less than 50% (37.9%) of the edema. Conclusion: The intensive treatment of lymphedema in the outpatient clinic can produce significant reductions in the volume of edema over a short period of time and can be recommended for any grade of lymphedema, in particular the more advanced degrees.

How to cite this article:
Pereira de Godoy JM, Azoubel LM, Guerreiro de Godoy M. Intensive treatment of leg lymphedema.Indian J Dermatol 2010;55:144-147

How to cite this URL:
Pereira de Godoy JM, Azoubel LM, Guerreiro de Godoy M. Intensive treatment of leg lymphedema. Indian J Dermatol [serial online] 2010 [cited 2021 Jan 28 ];55:144-147
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Lymphedema is a type of edema that occurs due to an abnormal accumulation of fluids and other substances in the tissues resulting from a failure of the lymphatic system associated with insufficiency of extralymphatic proteolysis of proteins in the cell interstice and the mobilization of macromolecules, [1] such as hyaluronic acid. [2]

Lymph drainage, [3],[4] exercising, [5],[6] hygienic precautions, [7],[8] compression mechanisms, [9] and more recently the association of occupational activities, [10] and cervical stimulation [11],[12] are recommended in the treatment of lymphedema. When lymphedema is established, the degree of dysfunction is great due to physical factors such as a decrease in joint mobility causing reductions in the amplitude of movements, the weight of the limb, pain, and disability to perform day-to-day tasks. [13] Treatments focusing on decreasing arm volume without addressing issues of pain may not result in improvements in activity, participation, or health-related quality of life. [14],[15]

Despite of all the problems caused by lymphedema, this disease continues to affect millions of people worldwide. Thus, the identification of the most efficacious forms of treatment of this disease is necessary. The objective of this study was to evaluate a novel intensive lymphedema treatment in the outpatient clinic.


Twenty-three legs of 5 male and 14 female patients with ages ranging between 27 and 75 years (mean age 49.1 years) were evaluated in a prospective quasi-randomized study. The diagnosis of lymphedema was clinical with confirmation by lymphoscintigraphy for some patients. Inclusion of patients was by order of arrival in the treatment center where individuals were invited to participate after the objectives of the study had been explained. The inclusion criterion was patients with Grade II and III lymphedema when the difference between legs below the knees, as evaluated by volumetry, was greater than 1.5 kg. Patients who were unable to perform volumetry of the limb due to its size and the size of the container, those with acute infections, and those with differences of less than 1.5 kg were excluded from the study.

Volumetry using the water displacement technique was performed for the lower leg before the start of treatment and weekly thereafter for the 4-week study period. For the evaluation, improvements in the difference between the healthy and affected limbs were considered or in cases of bilateral lymphedema, the total reduction at the end of the treatment period.

An intensive form of treatment was utilized with daily 6- to 8-h sessions in the outpatient clinic. Mechanical lymph drainage using the RAGodoy; apparatus [16] was performed for 6 to 8 h associated with the Godoy and Godoy cervical stimulation technique for 20 min per day [11],[12] and manual lymph drainage utilizing the Godoy and Godoy technique [3],[17] for 1-h session daily. With the exception of the session of manual lymph drainage, compression was applied using a home-made stocking made of a low-elasticity cotton-polyester material. [2],[18] First the compression stocking was put on, and then mechanical lymph drainage was performed followed by cervical stimulation and finally manual lymph drainage.

Analysis of variance was used for statistical analysis with an alpha error of 5% (P-value P-value P-value [19] Hence, there are several options for both the treatment and maintenance of lymphedema. Another aspect to be considered is the clinical treatment of lymphedema, where surgery is only indicated for the removal of masses from the feet when necessary, a situation that occurred in two cases in this study. Control of the reduction of lymphedema of limbs is vital to avoid skin folds, as this can cause pain and skin lesions with to the use of compression. These complications during treatment were solved by reducing the time of treatment sessions, with careful observation until the skin retracted at which time compression could again be used. Thus, it is possible to reduce large volumes of lymphedema just with clinical treatment.

In this study we excluded patients with small differences between the legs because total reduction of the edema can occur within the first week for many of them and hence the criteria related to the weight difference were so that reductions could be observed during the entire 4-week treatment period.

Several observations were made during the evolution of this treatment which may help to better understand this approach to lymphedema treatment. One observation is related to the compression mechanism; its removal at bedtime allows an increase in the volume of the leg during the night and so for this reason the use of the stocking is necessary over the 24 h of this initial phase in order to achieve the greatest loss in volume. During the night, when patients remove the stockings the loss in volume will be slower. Tolerance is good, in part, because of the prospective of good results motivating the patients and hence contributing to treatment. In another study, we evaluated the association of elastic bandages utilized over the cotton-polyester stockings. This association increases the volume losses although the technique is not always tolerated well by patients.

The objective of these studies is to identify the most efficacious options in all forms of treatment including in respect to filariasis and children. [20],[21]

Lymphoscintigraphy can be used for the diagnosis of lymphedema and to assess possible alterations that occur with the treatment. [22],[23] The different forms of lymphedema treatment should be considered and adapted to the situation of each patient. This form of treatment can be adapted to treat large populations with lymphedema at a low cost and reduce the suffering of great numbers of patients with lymphedema.


Intensive treatment of outpatients with all grades of lymphedema can give significant reductions in the volume of the edema over a short period of time particularly with the most advanced degrees of the disease.


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