Indian Journal of Dermatology
ORIGINAL ARTICLE
Year
: 2009  |  Volume : 54  |  Issue : 3  |  Page : 255--257

Mucocutaneous changes in tuberous sclerosis complex: A clinical profile of 27 Indian patients


Sudip Kumar Ghosh1, Debabrata Bandyopadhyay1, Gobinda Chatterjee1, Arghyaprasun Ghosh1, Sharmila Sarkar2, Somenath Sarkar1 
1 Departments of Dermatology, Venereology and Leprosy, R.G.Kar Medical College, Kolkata, India
2 Department of Psychiatry, Medical College Calcutta, India

Correspondence Address:
Sudip Kumar Ghosh
P.O. Rajballavpur (Via. Maslandapur), Dist-24, Parganas (N), West Bengal - 743 289
India

Background: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease resulting in a wide array of clinical manifestations, primarily affecting the skin and central nervous system. Mucocutaneous features play a very important role in the recognition of this syndrome. Aims: To review the prevalence and patterns of cutaneous manifestations in tuberous sclerosis, in a group of patients from eastern India. Methods: Observational clinical study on twenty-seven consecutive patients of tuberous sclerosis collected during a period of four years. Results: Most were between 10-20 years of age; the male to female ratio was 2:1. Family history was found in two-thirds. The classical triad of tuberous sclerosis was present in only nine (33.3%) patients. Adenoma sebaceum was the most common cutaneous feature (100%), followed by hypomelanotic macules (92.6%), connective tissue nevi (66.6%), and Koenen«SQ»s tumors (33.3%). Oral mucosal fibromas were seen in six (22.22%) patients. Fibromatous plaque over forehead and scalp was seen in three patients. Limitation of the study was small size of study sample. Conclusion: Prominent mucocutaneous changes are extremely common manifestation of TSC, which may provide crucial diagnostic clues for primary care physicians.


How to cite this article:
Ghosh SK, Bandyopadhyay D, Chatterjee G, Ghosh A, Sarkar S, Sarkar S. Mucocutaneous changes in tuberous sclerosis complex: A clinical profile of 27 Indian patients.Indian J Dermatol 2009;54:255-257


How to cite this URL:
Ghosh SK, Bandyopadhyay D, Chatterjee G, Ghosh A, Sarkar S, Sarkar S. Mucocutaneous changes in tuberous sclerosis complex: A clinical profile of 27 Indian patients. Indian J Dermatol [serial online] 2009 [cited 2021 Oct 16 ];54:255-257
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2009;volume=54;issue=3;spage=255;epage=257;aulast=Ghosh;type=0