Indian Journal of Dermatology
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Year : 2020  |  Volume : 65  |  Issue : 6  |  Page : 560-561
Solitary eccrine syringofibroadenoma of the dorsum of hand

1 Department of Dermatology, West China Hospital, Sichuan University; Department of Dermatology, Chengdu Second People's Hospital, Chengdu, Sichuan, China
2 Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

Date of Web Publication23-Oct-2020

Correspondence Address:
Lin Wang
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.IJD_331_18

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How to cite this article:
Zhou P, Li F, Liu H, Wang L. Solitary eccrine syringofibroadenoma of the dorsum of hand. Indian J Dermatol 2020;65:560-1

How to cite this URL:
Zhou P, Li F, Liu H, Wang L. Solitary eccrine syringofibroadenoma of the dorsum of hand. Indian J Dermatol [serial online] 2020 [cited 2020 Nov 28];65:560-1. Available from: https://www.e-ijd.org/text.asp?2020/65/6/560/298911


A 50-year-old woman presented with a papule on her left hand dorsum for 3 months. The lesion was asymptomatic but occasionally bled because of picking. The woman was healthy and denied previous trauma, relevant family history, or any systemic disease like diabetes. Physical examination revealed a flesh-colored papule of 0.4 cm in diameter on her left hand dorsum and mild erosion on the surface of the papule [Figure 1]. The examination of hair, mucosae, and nails was normal. We resected the lesion. Histopathological examination revealed thin, interconnected cell cords extending from multiple sites of the epidermis to the middle layer of the dermis, surrounded by fibrovascular stroma. The cell cords were composed of small squamous cells, some of which formed small ductal structures. A complete eosinophilic membrane was wrapped around the edge of the lumen [Figure 2]. The immunohistochemical stainings for endothelial membrane antigen (EMA) and periodic acid-Schiff (PAS) were both positive [Figure 3]. Bilayer structure of the glandular arrangement, positive of PAS and EMA, supported the origin of eccrine sweat glands. Thus, we diagnosed eccrine syringofibroadenoma (ESFA). The patient remained free of recurrence at 6-month follow-up.
Figure 1: A flesh-colored papule approximately 0.4 cm in diameter on the dorsum of left hand

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Figure 2: The thin epithelial intertwined cords derived from the epidermis and surrounded by fibrovascular stroma (H and E, [a] ×40, [b] ×100)

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Figure 3: The immunohistochemical staining of (a) endothelial membrane antigen and (b) periodic acid.Schiff were positive (×200)

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ESFA is a rare benign tumor of eccrine sweat gland, which can be divided into five subtypes: (1) solitary, (2) multiple, connected with hidrotic ectodermal dysplasia, (3) multiple, without connected cutaneous features, (4) unilateral linear, and (5) reactive ESFA.[1] All clinical subtypes have similar typical histopathological features as anastomosing cords and strands of uniform epithelial cells surrounded by fibrovascular stroma.

Clinically, pyogenic granuloma and verruca vulgaris should be taken into consideration for differential diagnosis. The former usually has a history of trauma, which is characterized by red or dark-red papules and nodules, and the latter has a rough or verrucous surface. Both of them can be distinguished easily according to the histopathological examination.

The histopathological differential diagnosis may include acrosyringeal nevus, fibroepithelial tumor of Pinkus, eccrine poroma, and syringofibroadenocarcinoma.[2] Plasma cell infiltrates, and strong PAS positivity is characteristic of acrosyringeal nevi. The fibroepithelial tumor of Pinkus shows local changes (typical of basal cell carcinoma) with peripheral palisade and suturing artifacts and a loose fibrous matrix. Eccrine poromas show more uniform proliferation of small epithelial cells with vertical thick strands stretching into the dermis. Syringofibroadenocarcinomas display a shift where malignant phenotypic cytogenetic abnormalities can be seen.

ESFA is rare, with only about 50 cases reported.[1] ESFA has been reported in the heel, dorsum of foot, leg, finger, and perianal region. To the best of our knowledge, only one case has been reported from China, and that case mimicked verruca vulgaris on the extremities.[3] Our patient presented a minute papule on the dorsum of hand. Compared with other patients, the present patient had a smaller lesion and shorter clinical course.

ESFA is a benign tumor. However, malignant transformation into eccrine porocarcinoma, syringofibroadenocarcinoma, or a correlation with squamous cell carcinoma have been reported.[4],[5] Hence, the recommended treatment of ESFA is surgical excision to prevent possible malignant transformation. Laser treatment and cryotherapy are not recommended before a definite diagnosis.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

   References Top

Dongre AM, Nikam VV, Pathave HS, Malladi N. Perianal eccrine syringofibroadenoma. Indian J Dermatol 2017;62:548.  Back to cited text no. 1
[PUBMED]  [Full text]  
Tiwary AK, Firdous J, Mishra DK, Chaudhary SS. A case report of reactive solitary eccrine syringofibroadenoma. Indian Dermatol Online J 2017;8:35-8.  Back to cited text no. 2
[PUBMED]  [Full text]  
Xu XL, Zhang W, Liu WD, Sun JF. A case of multiple eccrine syringofibroadenoma mimicking verruca vulgaris. J Dermatol 2013;40:665-6.  Back to cited text no. 3
Katane M, Akiyama M, Ohnishi T, Watanabe S, Matsuo I. Carcinomatous transformation of eccrine syringofibroadenoma. J Cutan Pathol 2003;30:211-4.  Back to cited text no. 4
Bjarke T, Ternesten-Bratel A, Hedblad M, Rausing A. Carcinoma and eccrine syringofibroadenoma: A report of five cases. J Cutan Pathol 2003;30:382-92.  Back to cited text no. 5


  [Figure 1], [Figure 2], [Figure 3]


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