Indian Journal of Dermatology
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Year : 2020  |  Volume : 65  |  Issue : 6  |  Page : 473-482

A nationwide, multicentric case–control study on vitiligo (MEDEC-V) to elicit the magnitude and correlates

1 Department of Dermatology, Dr B C Roy Post Graduate Institute of Pediatric Science, Kolkata, West Bengal, India
2 Department of RG Kar Medical College, Kolkata, West Bengal, India
3 K J Somaiya Medical College, Mumbai, Maharashtra, India
4 Mandya Institute of Medical Sciences, Mandya, Karnataka, India
5 RNT Medical College, Udaipur, Rajasthan, India
6 Victoria/Bowring Hospitals, Bangalore Medical College and RI, Karnataka, India
7 CIHSR, 4TH MILE, Dimapur, Nagaland, India
8 NRS Medical College, Kolkata, West Bengal, India
9 Government Medical College, Latur, Maharashtra, India
10 Malda Medical College, Malda, West Bengal, India
11 Departments of Community Medicine, Calcutta National Medical College, Kolkata, India
12 Pariyaram Medical College, Kannur, Kerala, India
13 NEIGRIHMS, Shillong, Meghalaya, India
14 Bangalore Medical College and RI, Bangalore, Karnataka, India
15 Dr. Somervell Memorial CSI Medical College, Karakonam, Trivandrum, Kerala, India
16 GMERS Medical College, Sola, Ahmedabad, Gujarat, India
17 Perundurai Medical College Hospital, Erode, Tamil Nadu, India
18 MM Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India
19 Government Medical College, Amritsar, Punjab, India

Correspondence Address:
Nilendu Sarma
P.N. Colony, Sapuipara, Bally, Howrah - 711 227, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.IJD_822_19

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Background: Vitiligo is an acquired, idiopathic, and common depigmentation disorder. The values of various epidemiologic parameters are often doubtful due to the methodological weaknesses of the studies. Aims: To elicit the magnitude of various epidemiological parameters and important correlates of vitiligo. Materials and Methods: Every vitiligo patient attending the outpatient department of medical colleges spread over most of the Indian states were examined over a period of 1 year. Various epidemiological and clinical variables were examined and compared with age and sex-matched controls (registered in the Clinical Trial Registry of India CTRI/2017/06/008854). Results: A total of 4,43,275 patients were assessed in 30 medical colleges from 21 Indian states. Institutional prevalence of vitiligo was 0.89% (0.86% in males and 0.93% in females,P <0.001). The mean age at presentation and mean age at onset were 30.12 ± 17.97 years and 25.14 ± 7.48 years, respectively. Head–neck was the most common primary site (n = 1648, 41.6%) and most commonly affected site (n = 2186, 55.17%). Most cases had nonsegmental vitiligo (n = 2690, 67.89%). The disease started before 20 years of age in more than 46% of cases. About 77% of all cases had signs of instability during the last 1 year. The family history, consanguinity, hypothyroid disorders, and depressed mood were significantly (P < 0.001) higher among the cases. First, second, and third-degree family members were affected in 269 (60.04%), 111 (24.78%), and 68 (15.18%) cases, respectively. Work-related exposure to chemicals was significantly higher among cases (P < 0.008). Obesity was less common among vitiligo cases [P < 0.001, odds ratio (OR) 0.78, 95% confidence interval (CI): 0.71–0.86]. Conclusion: This is one of the largest studies done on vitiligo in India. The prevalence of vitiligo was found to be 0.89% among hospital attendees. Prevalence of vitiligo was higher among females than in males and prevalence of family history, consanguinity, hypothyroid disorders were higher in vitiligo than among controls.

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