Indian Journal of Dermatology
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Year : 2019  |  Volume : 64  |  Issue : 4  |  Page : 321-323

Pompholyx-like eruptions induced by penicillamine in a patient with wilson's disease

1 Department of Dermatology, St. Johns Medical College Hospital, Bengaluru, Karnataka, India
2 Department of Gastroenterology, St. Johns Medical College Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Diana Elizabeth Devassy
Department of Dermatology, St. Johns Medical College Hospital, Sarjapur Road, Bengaluru - 560 034, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.IJD_328_18

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Wilson's disease is an inherited disorder of copper metabolism that results in excessive accumulation of copper in various organs, with liver being the primary site of involvement. D-penicillamine (DPA) as a chelating agent forms the mainstay of therapy; however, it can cause a myriad of adverse effects on long-term use. The major adverse effects reported with DPA include disorders of collagen synthesis, such as pseudoxanthoma elasticum-like lesions, autoimmune blistering diseases, and urticarial lesions. Here, we report a young girl who developed extensive pompholyx-like blisters within a few months of starting DPA which on histopathology showed a spongiotic reaction. The lesions improved on stopping DPA and initiation of oral steroids.

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