Indian Journal of Dermatology
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Year : 2019  |  Volume : 64  |  Issue : 1  |  Page : 68-70

Systemic retinoids and scar dehiscence

1 Department of Plastic and Reconstructive Surgery, Bahcesehir University, Istanbul; Plastic, Reconstructive and Aesthetic Surgery Clinic, VM Medicalpark Kocaeli Hospital, Aksaray, Turkey
2 Department of Dermatology, Faculty of Medicine, Bahcesehir University, Istanbul; Dermatology Clinic, VM Medicalpark Kocaeli Hospital Kocaeli, Aksaray, Turkey
3 Department of Dermatology, Faculty of Medicine, Aksaray University, Aksaray, Turkey

Correspondence Address:
Dr. Berna Aksoy
VM Medicalpark Kocaeli Hospital, Ovacik Discreet, Beside D-100 Highway, No: 36, Basiskele, Kocaeli
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Source of Support: None, Conflict of Interest: None

DOI: DOI: 10.4103/ijd.IJD_148_18

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Systemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice. Several studies have reported the wound-healing effects of treatment with concurrent systemic retinoids in addition to surgical treatments. Herein, we describe two patients with scar dehiscence that developed after initiation of systemic retinoid treatment following cutaneous surgery. In Case 1, isotretinoin was thought to decrease collagen production to a greater degree than did degradation during the wound remodeling phase, which resulted in wound dehiscence. In Case 2, acitretin was thought to decrease fibroblast proliferation and collagen production during the proliferation phase of wound healing, which resulted in wound dehiscence. Based on the two presented cases, it is advisable to postpone systemic retinoid treatment for 6 months to 1 year following cutaneous surgery, located especially in cosmetically important sites.

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