Indian Journal of Dermatology
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Year : 2016  |  Volume : 61  |  Issue : 2  |  Page : 235

Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma

1 Department of Dermatology, Hotel-Dieu de France University Hospital, Beirut, Lebanon
2 Department of Oncology, Bellevue Medical Center, Beirut, Lebanon

Correspondence Address:
Elio Kechichian
Hotel-Dieu de France University Hospital, Alfred Naccache St., Achrafieh, Beirut
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.177784

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Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic lymphomas. We report the first case of a lamotrigine-induced DRESS with histologic features of a cutaneous CD30+ lymphoma. The patient responded well to a tapering course of oral steroids. This case highlights the atypical presentation of a lamotrigine-induced DRESS/DIHS in the presence of a cutaneous and a lymph node CD30 + lymphocytic infiltrate mimicking systemic lymphoma. Pathologists and clinicians must be aware of this “lymphomatous” presentation of drug reactions.

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