Indian Journal of Dermatology
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Year : 2016  |  Volume : 61  |  Issue : 2  |  Page : 216-218

Primary systemic amyloidosis with unusual dermatological manifestations: A rare case report

Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India

Correspondence Address:
Suresh Kumar Jain
Department of Dermatology, Venereology and Leprology, Government Medical College, Kota - 324 001, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.177767

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Amyloidosis is a group of heterogeneous diseases characterized by pathological deposition of proteinaceous substance extracellularly in various tissues. The clinical presentation depends on the site of amyloid deposition, with predominant involvement of mesenchymal elements and cutaneous findings in 30–40% of patients in case of primary systemic amyloidosis. We present a case of idiopathic primary systemic amyloidosis presenting with an unusual finding of nodulo-ulcerative lesion over tongue along with multiple skin-colored nodules, mimicking squamous cell carcinoma of tongue with secondary cutaneous metastasis, as well as lacking the classical presentation of purpura, macroglossia, waxy papules, and plaques.

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