Indian Journal of Dermatology
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INVESTIGATIVE DERMATOLOGY
Year : 2016  |  Volume : 61  |  Issue : 2  |  Page : 169-173

Urinary biopyrrins: A new marker of oxidative stress in psoriasis


1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Shibin Al Koom, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufiya University, Shibin Al Koom, Egypt

Correspondence Address:
Ola Ahmed Bakry
Department of Dermatology, Andrology and STDs, Menoufiya Faculty of Medicine, Shibin Al Koom 32817
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.177756

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Background: Psoriasis is a common chronic, relapsing, immune-mediated disease involving skin and joints of genetically predisposed individuals. Oxidative stress has been found to play many important roles in cellular damage and loss of function in a number of tissues and organs and is believed to contribute to the pathogenesis of a variety of diseases. Urinary biopyrrin levels have gained attention as an indicator of oxidative stress. Aim and Objective: To measure urinary biopyrrins excretion as a marker of oxidative stress in psoriasis. Patients and Methods: This case–control study was carried out on 85 subjects; 55 cases with chronic plaque psoriasis and 30 age, gender and body mass index-matched normal subjects as a control group. Urinary biopyrrin levels were measured using enzyme immunoassay. Results: There was a highly significant difference between cases and controls regarding urinary biopyrrins level (P < 0.001). There was significant positive correlation between biopyrrins level and both the age of cases (r = 0.28, P = 0.01) and psoriasis area and severity index score (r = 0.99, P < 0.001). Conclusion: Urinary biopyrrins are increased in patients with psoriasis, and the level is correlated with disease severity. Further large-scale studies involving different ages and different clinical varieties of the disease are needed to expand and validate current findings. The clinical usefulness of antioxidants in psoriasis treatment needs to be evaluated in future research. Furthermore, the value of biopyrrins as biomarkers for monitoring response to therapy needs to be evaluated.


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