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Indian Journal of Dermatology
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Year : 2015  |  Volume : 60  |  Issue : 5  |  Page : 516-517
Asymptomatic papular eruption in a 60 year old man


1 Department of Dermatology, S.B.K.S. MIRC, Sumandeep Vidyapeeth University, Waghodia, Piparia, Vadodara, Gujarat, India
2 Department of Pathology, S.B.K.S. MIRC, Sumandeep Vidyapeeth University, Waghodia, Piparia, Vadodara, Gujarat, India

Date of Web Publication4-Sep-2015

Correspondence Address:
Rashmi S Mahajan
Department of Dermatology, Dhiraj Hospital, Waghodia Road, Vadodara - 301 760, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.164391

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How to cite this article:
Mahajan RS, Shah AC, Pasle RK, Bilimoria FE. Asymptomatic papular eruption in a 60 year old man. Indian J Dermatol 2015;60:516-7

How to cite this URL:
Mahajan RS, Shah AC, Pasle RK, Bilimoria FE. Asymptomatic papular eruption in a 60 year old man. Indian J Dermatol [serial online] 2015 [cited 2021 Aug 5];60:516-7. Available from: https://www.e-ijd.org/text.asp?2015/60/5/516/164391


A 60-year-old man presented with asymptomatic, bilaterally symmetrical gradually progressive, generalized papular eruption since 3 months. Few lesions had spontaneously regressed, while others persisted. There was no history of insect bite reaction, viral fever, drug intake prior to onset of lesions.

Examination revealed bilaterally symmetrical discrete skin colored papules ranging from 2 to 4 mm in diameter over upper [Figure 1]a and lower limbs [Figure 1]b. The palms, soles, and mucosae were spared. General physical examination revealed no abnormality.
Figure 1: (a) Multiple skin colored papules over both forearms (b) Discrete papules over inner aspect of arm (c) Discrete papules over inner aspect of thigh

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Routine blood investigations including lipid profile were within normal limits. Histopathology from papule over forearm revealed histiocyte-like cells, irregularly grouped in upper and middermis. The cells had pale cytoplasm with oval nuclei [Figure 2]a. An immunohistochemistry showed that the histiocyte-like cells expressed CD 68 and were negative for S100 and CD1a [Figure 2]b.
Figure 2: (a) Irregularly grouped histiocytes in upper and middermis (b) Immunohistochemistry demonstrating CD68 positivity

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   Question Top


What is your diagnosis?



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   References Top

1.
Marzano AV, Facchetti M, Caputo R. Guess what! Generalized eruptive histiocytosis (histiocytoma). Eur J Dermatol 2002;12:205-6.  Back to cited text no. 1
    
2.
Shon W, Peters MS, Reed KB, Ketterling RP, Dogan A, Gibson LE. Atypical generalized eruptive histiocytosis clonally related to chronic myelomonocytic leukemia with loss of Y chromosome. J Cutan Pathol 2013;40:725-9.  Back to cited text no. 2
    
3.
Lan Ma H, Metze D, Luger TA, Steinhoff M. Successful treatment of generalized eruptive histiocytoma with PUVA. J Dtsch Dermatol Ges 2007;5:131-4.  Back to cited text no. 3
    
4.
Tang X, Shen H, Xu A, Sun X, Wang Y, Shi G, et al. Spontaneous regression of generalized eruptive histiocytosis: Possible involvement of apoptosis. Int J Dermatol 2007;46:1073-5.  Back to cited text no. 4
    
5.
Goodman WT, Barret TL. Histiocytoses. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2 nd ed. Amsterdam: Elsevier; 2008. p. 1395-402.  Back to cited text no. 5
    
6.
Chern E, Yau D, Ho JC. Generalized eruptive histiocytosis in an infant. Acta Derm Venereol 2010;90:204-5.  Back to cited text no. 6
    


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