Indian Journal of Dermatology
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Year : 2015  |  Volume : 60  |  Issue : 4  |  Page : 423

Darier's disease in gastric malignancy: An unusual paraneoplastic phenomenon

Department of Dermatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India

Correspondence Address:
Dr. Anusree Gangopadhyay
3/26, R. K. Chatterjee Road, Joyce Apartment, Near Kasba Old Police Station, Kolkata - 700 042, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.160535

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Darier's disease is an autosomal dominant genodermatosis resulting from ATP2A2 gene mutation. A 62-year-old male presented at our outpatient (OPD) with sudden-onset numerous dirty, warty papules over the head, neck, and back since 2 months. Histopathology of the skin lesions revealed acantholytic dyskeratosis suggestive of Darier's disease. He was referred to the gastroenterology department for some gastrointestinal (GI) symptoms where he was diagnosed with adenocarcinoma of the stomach and was subsequently operated. On his next visit to our department for follow-up, we found a marked diminution of the skin lesions in the absence of any specific treatment. In view of the above finding, we concluded that paraneoplastic dermatosis in the form of Darier's disease occurred in this patient. Paraneoplastic Darier's disease with gastric adenocarcinoma is not yet described in dermatology literature and is hence reported here.

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