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Indian Journal of Dermatology
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THERAPEUTIC ROUND
Year : 2015  |  Volume : 60  |  Issue : 4  |  Page : 364-368

Repigmentation of hypopigmented scars using combination of fractionated carbon dioxide laser with topical latanoprost vs. fractionated carbon dioxide laser alone


1 Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan; Department of Dermatology, Medicine Students' Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Epidemiology and Biostatistics, School of Medicine, Qom University of Medical Sciences, Qom, Iran
4 Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Reza Rezaei
Department of Dermatology, Al-Zahra Hospital, Soffeh Boulevard, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: This work was supported financially by a grant from Isfahan University of Medical Sciences (research proposal number 392019), Conflict of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the manuscript.


DOI: 10.4103/0019-5154.160481

Clinical trial registration IRCT2013123016002N1

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Background: Fractionated carbon dioxide (CO 2 ) can treat hypopigmented scars. Latanoprost is a prostaglandin analog used to treat glaucoma. It can cause adverse effects, such as periocular hyperpigmentation. The aim of this study was to assess the efficacy and safety of latanoprost plus CO 2 laser on the repigmentation of hypopigmented scars. Patients and Methods: 28 patients with hypopigmented scars were divided randomly into two groups. The patients in group A were treated in six sessions (1-month intervals) with 10600-nm fractional CO 2 laser plus latanoprost 0.005% and those of group B fractionated CO 2 laser plus placebo (distilled water). Digital photographs were taken at baseline and 3 months after the last treatment session. The blinded dermatologist compared the photographs and evaluated the efficacy of treatment in the hypopigmented scars using a 4-scale point (grade 1-4). Patient satisfaction was scored from 0 to 10 on a visual analog scale. Results: Follow-up results 12 weeks after the last treatment session demonstrated that 11 of the 14 patients in group A had more than 50% improvement in hypopigmentation The difference in improvement of the two groups was statistically significant (P = 0.027). The mean of the VAS scores of patients in group A was 6.50 ± 1.45 and in group B 4.57 ± 1.6. The difference in mean satisfaction of the two groups was statistically significant (P = 0.003). Side effects were mild and resolved within 1 to 5 days. Conclusion: The fractional CO 2 laser resurfacing plus topical latanoprost can be used as a safe and efficacious method to treat hypopigmented scars.


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