Indian Journal of Dermatology
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Year : 2015  |  Volume : 60  |  Issue : 3  |  Page : 323

Co-existence of multicentric Castleman's disease and Kaposi's sarcoma

Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Correspondence Address:
Nader Pazyar
Department of Dermatology, Imam Hospital, Azadegan Street, Ahvaz
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.156457

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Castleman's disease (CD) or giant lymph node hyperplasia is a rare disorder that can be unicentric or multicentric. Multicentric Castleman's disease (MCD) is manifested by generalized lymphadenopathy, hepatosplenomegaly, polyclonal hypergammaglobulinemia, hematological abnormality, and constitutional symptoms. Human herpesvirus 8 (HHV-8) infection is present in nearly 100% MCD associated with HIV-1 infection, but in about 50% of cases of HIV negative. Herein, we report a 77-year-old man with systemic involvement and skin lesions on the anterior aspect of both legs in the previous site of saphenous vein angioplasty. Co-existence of MCD with Kaposi's sarcoma (KS) led us to present this rare case.

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