Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
Users online: 399  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
Year : 2015  |  Volume : 60  |  Issue : 3  |  Page : 321

Evaluation of the association between epstein-barr virus and mycosis fungoides

1 Department of Dermatology, Cutaneous Leishmanaisis Research Center, Mashhad, Iran
2 Department of Pathology, Cutaneous Leishmanaisis Research Center, Mashhad, Iran
3 Department of Microbiology, Research Center for Microbiology and Virilogy, Imam Reza Hospital, Faculty of Medicine, Mashhad, Iran
4 Department of Biostatistics and epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Emergency Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Naser Tayyebi Meibodi
Cutaneous Leishmanaisis Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad
Login to access the Email id

Source of Support: Research Deputy of Mashhad University of Medical Sciences, Conflict of Interest: None

DOI: 10.4103/0019-5154.156423

Rights and Permissions

Introduction: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphomas. Despite extensive studies, etiopathogenesis of MF is unknown. Environmental, infectious and genetic factors have been proposed as potential risk factors of MF. Herpes virus family members, especially Epstein-Barr virus (EBV), have been among the viral factors of interest in recent years. The aim of this study was to investigate the possible association of EBV infection with MF. Materials and Methods: This case-control study was performed on skin biopsy samples of 57 MF patients referred to Pathology Department of Mashhad Emam Reza Hospital from 2000 to 2011 and also on 57 melanocytic nevus samples matched with patients for age and sex. The presence of EBV in samples was evaluated by polymerase chain reaction. Statistical analysis of the data was conducted with the Statistical Package for the Social Sciences version 11.5 (SPSS Inc., Chicago, IL, USA). Results: In this study, out of 57 MF samples, there were 34 male and 23 female patients, with male:female ratio of 1.04. Mean patient age was 51.4 years. There were 22 and 4 positive cases of EBV in the case and control groups, respectively. Chi-square statistical test showed that EBV was significantly higher in case group than control (P = 0.000). There was no correlation between the presence of EBV in samples with lesion type, age and gender of the patients. Conclusion: According to our study results, EBV is a likely etiologic agent or potential promoter in the pathogenesis of MF.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded47    
    Comments [Add]    

Recommend this journal