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Table of Contents 
RESIDENT PAGE
Year : 2015  |  Volume : 60  |  Issue : 3  |  Page : 276-279
Vaccines in dermatology


Department of Dermatology, Sumandeep Vidhyapeeth, Waghodia Road, Piparia, Vadodara, Gujarat, India

Date of Web Publication6-May-2015

Correspondence Address:
Mitali M Shah
Department of Dermatology, Sumandeep Vidhyapeeth, Waghodia Road, Piparia, Vadodara 391 760, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.156378

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   Abstract 

A vaccine is a biological preparation that improves immunity to a specific disease. More than two centuries have passed since the first successful vaccine for smallpox was developed. We've come a long way since. Today's vaccines are among the 21 st century's most successful and cost-effective public health tools for preventing diseases.


Keywords: Dermatology, immunity, vaccine


How to cite this article:
Shah MM, Shah AC, Mahajan RS, Bilimoria FE. Vaccines in dermatology. Indian J Dermatol 2015;60:276-9

How to cite this URL:
Shah MM, Shah AC, Mahajan RS, Bilimoria FE. Vaccines in dermatology. Indian J Dermatol [serial online] 2015 [cited 2021 Jul 26];60:276-9. Available from: https://www.e-ijd.org/text.asp?2015/60/3/276/156378

What was known?
In the past, most vaccines were aimed at infants and children but now adolescents, adults and elders are increasingly being targeted. Recently new methods of administering vaccines are being developed such as skin patches, aerosols and eating genetically engineered plants. Now Attempts are being made to develop vaccines that help to cure of chronic diseases and all escapable concerns of human being as opposed to preventing infectious diseases only.



   Introduction Top


To become permanently immune to some illness, you must either catch it or be vaccinated against it.

Vaccine is an antigenic substance prepared from the causative agent of a disease or a synthetic substitute, used to provide immunity against disease.

During vaccination, a harmless version of a germ is introduced to the body and the immune system responds by producing antibodies to attack the intruder. Thereafter, a memory of this "invasion" remains so that the immune system can quickly recognize and neutralize disease causing agents when they appear [Figure 1].
Figure 1: Action of vaccine

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Different Types of Vaccines [1]

  • Weaker or attenuated viruses to generate immunity
  • Live viruses that have been attenuated (weakened or altered so as not to cause illness)
  • Inactivated or killed organisms or viruses
  • Inactivated toxins (for bacterial diseases where toxins generated by the bacteria, and not the bacteria themselves, cause illness)
  • Segments of the pathogen (this includes both subunit and conjugate vaccines).


As dermatologists, we should be aware of the practical significance of the commonly used vaccines. Further, vaccines are newer options for prevention of transmission of several communicable diseases. Herein the commonly used and experimental vaccines of relevance to dermatology have been elucidated in a simplified manner [Table 1] and [Table 2] [9].
Table 1: Vaccines of dermatological significance


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Table 2: Vaccines dose, indications, effects and side effects


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   References Top

1.
Niaid.nih.gov. 2012-04-03. Retrieved 2013-04-26.  Back to cited text no. 1
    
2.
Sehgal VN, Sardana K. Lepra vaccine: Misinterpreted myth. Int J Dermatol 2006;45:164-7.  Back to cited text no. 2
    
3.
Sharma VK. Vaccines against sexually transmitted infections; Sexually transmitted diseases and HIV/AIDS. Vinod vasishtha for viva books private limited, New Delhi, 2009. p. 665.  Back to cited text no. 3
    
4.
FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2010;59:1184.  Back to cited text no. 4
    
5.
Whitley RJ, Roizman B. Herpes simplex viruses: Is a vaccine tenable?. J Clin Invest 2002;110:145-51.  Back to cited text no. 5
    
6.
Prymula R, Bergsaker MR, Esposito S, Gothefors L, Man S, Snegova N, et al. Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine versus one dose of monovalent varicella vaccine: A multicentre, observer-blind, randomised, controlled trial. Lancet 2014;383:1313-24.  Back to cited text no. 6
    
7.
Wellington K, Goa KL. Measles, mumps, rubella vaccine (Priorix; GSK-MMR): A review of its use in the prevention of measles, mumps and rubella. Drugs 2003;63:2107-26.  Back to cited text no. 7
    
8.
Ghosh S. Pathogenesis and management of acne, Recent advances in Dermatology, 2014;3:43.  Back to cited text no. 8
    
9.
Kiran K, Kar HK, Kumar B. Leprosy vaccine and immunotherapy : Jaypee brothers medical publishers, New Delhi. IAL textbook of leprosy; 2010. p. 410-23.  Back to cited text no. 9
    

What is new?
Advances in genetics, immunology and molecular biology has helped researchers to make vaccines with safer alternatives.Ongoing research shows promise in therapeutic as well as prophylactic vaccination for dermatological diseases. Newer vaccines for preventing and treating HIV, HSV, vaccines against acne and malignant melanoma etc have completed phase 1 trial successfully, so hopefully in future we can not only prevent but also fight and cure these diseases.


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1], [Table 2]



 

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