Indian Journal of Dermatology
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Year : 2015  |  Volume : 60  |  Issue : 2  |  Page : 212

Fluconazole-induced acute generalized exanthematous pustulosis

Department of Internal Medicine and Medical Specialities, Dermatology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy

Correspondence Address:
Vito Di Lernia
Unit of Dermatology, Arcispedale Santa Maria Nuova IRCCS, Viale Risorgimento 80, Reggio Emilia - 42123
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.152572

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Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is usually caused by drugs. It is characterized by fever and acute, extensive occurrence of disseminated sterile pustules, accompanied by fever, malaise and peripheral blood leucocytosis. There have been several reports to date of AGEP following exposure to antifungals. In particular, terbinafine is included in the list of the agents conferring the highest risk of AGEP. The authors report the case of a 70-year-old male patient who developed AGEP shortly after commencing treatment with fluconazole, which has been reported in association with AGEP in a single case report. To our knowledge, this is the first reported case of AGEP associated with positive fluconazole patch test.

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