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Indian Journal of Dermatology
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  Official organ of AADV
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ORIGINAL ARTICLE
Year : 2014  |  Volume : 59  |  Issue : 6  |  Page : 558-561

Altered serum uric acid level in lichen planus patients


1 Department of Biochemistry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India
2 Department of Dermatology, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India

Correspondence Address:
Dr. Goutam Chakraborti
Department of Biochemistry, Murshidabad Medical College and Hospital, Berhampore - 742 101, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.143510

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Background: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear. Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. Objectives: The principal aim of this study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in LP patients. Methods: Serum UA levels were determined in 58 LP patients and 61 controls. Results: Serum UA levels were significantly decreased in patients with respect to controls. Moreover, serum UA level was decreased according to increasing duration of disease. Conclusions: The results of our study suggest that LP is associated with decrease of UA levels in serum. UA may be a potential, useful biomarker of antioxidant status in LP for elaboration of treatment strategy and monitoring.


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