Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
Users online: 3142  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page

Table of Contents 
Year : 2014  |  Volume : 59  |  Issue : 4  |  Page : 421
The relationship between alopecia areata and alexithymia, anxiety and depression: A case-control study

1 Department of Psychiatry, Hédi Chaker University Hospital, Sfax, Tunisia
2 Department of Dermatology, Hédi Chaker University Hospital, Sfax, Tunisia

Date of Web Publication27-Jun-2014

Correspondence Address:
Dr. Rim Sellami
EL Ain Street Hedi Chaker University Hospital, Sfax
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.135525

Rights and Permissions


Background: Alopecia areata (AA) is a skin disease characterized by the sudden appearance of areas of hair loss on the scalp and other hair-bearing areas, but its aesthetic repercussions can lead to profound changes in patient's psychological status and relationships. Aim: The goal was to investigate a possible relationship between AA and alexithymia as well as two other emotional dimensions, anxiety and depression. Materials and Methods: Fifty patients with AA seen in the Department of Dermatology of Hedi Chaker University Hospital, Sfax were included in this study. Anxiety and depression were evaluated by Hospital Anxiety and Depression scale questionnaire, alexithymia was assessed by Toronto Alexithymia scale 20, and severity of AA was measured by Severity of Alopecia Tool. Results: Patient's mean age was 32.92 years. 52% of patients were females. Depression and anxiety were detected respectively in 38% and 62% of patients. There was statistically significant difference between patients and control group in terms of depression (P = 0.047) and anxiety (P = 0.005). Forty-two percent of patients scored positive for alexithymia. No significant difference was found between patient and control groups (P = 0.683) in terms of alexithymia. Anxiety was responsible for 14.7% of variation in alexithymia (P = 0.047). Conclusions: Our study shows a high prevalence of anxiety and depressive symptoms in AA patients. Dermatologists should be aware of the psychological impact of AA, especially as current treatments have limited effectiveness.

Keywords: Alexithymia, alopecia areata, anxiety, depression

How to cite this article:
Sellami R, Masmoudi J, Ouali U, Mnif L, Amouri M, Turki H, Jaoua A. The relationship between alopecia areata and alexithymia, anxiety and depression: A case-control study. Indian J Dermatol 2014;59:421

How to cite this URL:
Sellami R, Masmoudi J, Ouali U, Mnif L, Amouri M, Turki H, Jaoua A. The relationship between alopecia areata and alexithymia, anxiety and depression: A case-control study. Indian J Dermatol [serial online] 2014 [cited 2023 Mar 30];59:421. Available from:

What was known?
Alopecia areata as many other skin diseases can have a severe impact on psychological wellbeing. Several studies have shown a link between alexithymia and alopecia areata.

   Introduction Top

Alopecia areata (AA) is a skin disease of unknown etiology with prevalence of 0.2% in the general population. [1] This disorder occurs in both sexes, at all ages, [2] and is characterized by the sudden appearance of areas of hair loss on the scalp and other hair-bearing areas. Various factors, including immunological and endocrine abnormalities, [3] genetic factors, [4] infections, [5] and psychological/psychiatric disturbances have been claimed to play a role in its etiopathogenesis. [6]

As hair is an important component of identity and self-image, even partial hair loss can lead to a variety of psychological difficulties. [7],[8] AA can have psychosocial complications, including depression, low self-esteem, altered self-image, and less frequent and enjoyable social engagements. [9],[10] A link between alexithymia and AA has been suggested by several studies. [11],[12]

Alexithymia is defined as difficulty being aware of, recognizing, differentiating, and defining emotions, both of self and others. [13] It is hypothesized that alexithymic patients tend to "somatize" emotional problems because they cannot verbalize them. [14] Indeed, it has been reported that alexithymic features are more frequent in some psychosomatic disorders, [13] and AA is also considered a psychosomatic disease. [15]

The objectives of our study were to investigate a possible relationship between AA and alexithymia as well as two other emotional dimensions, anxiety and depression.

   Materials and Methods Top

All new patients diagnosed with AA and who did not have any previous episodes of AA seen in the Department of Dermatology of Hedi Chaker University Hospital Sfax between March 2010 and July 2010 were included in the study. Informed consent was obtained from all enrolled subjects. The diagnosis of AA was made by a qualified dermatologist on a clinical basis. Socio demographic and clinical data including age, sex, family history of AA, site of onset and associated diseases were recorded for all patients. Included patients underwent full clinical examination to determine the number and extension of the sites affected by AA and the severity of the disease. The control group included 50 healthy adults recruited from the hospital staff who did not currently or previously have any psychiatric and dermatological disorders. The controls were age-and gender-matched and did not work in an area related to psychiatry or psychology.

All of the patients and controls were evaluated by a Psychiatrist using the Toronto Alexithymia Scale (TAS) and the Hospital Anxiety and Depression Scale (HADS). Persons who were illiterate, who lacked the ability to communicate, or who had mental retardation were excluded from the study.

The severity of hair loss was assessed by measuring the percentage of the alopecic area on the scalp. Patients with AA were evaluated using Severity of Alopecia Tool (SALT). [16] The SALT score is computed by measuring the percentage of hair loss in each of 4 areas of the scalp (40% vertex, 18% right profile, 18% left profile, 24% posterior) and adding the total to achieve a composite score. Patients were divided according to disease severity: S1-S2: Hair loss below 50%; S3-S4: Hair loss of 50-99%; S5: Total scalp hair loss.

HADS is a self-report scale, which issued to determine the levels of anxiety and depression that a patient is experiencing. [17] It is administered to patients with physical diseases who consult to primary care units. It consists of 14 questions, seven of which measure anxiety, while the other seven measure depression.

TAS-20 is a 20-item self-report scale with a three-factor structure congruent with the alexithymia construct: difficulty in identifying feelings, difficulty in describing feelings, and externally oriented thinking. [18] Each item is rated on a five-point Likert scale ranging from 1 (strongly disagree) to 5 (strongly agree), with five items negatively keyed. The TAS-20 score ranges from 20 to 100; subjects scoring 61 or more have been suggested to be alexithymic.

For statistical analysis, we used the Statistical Package for Social Sciences, version 18. Statistical evaluations performed were student t-test, Chi-square test, and linear regression analysis. A P value less than 0.05 was considered statistically significant.

   Results Top

Fifty patients were included in this study. Their mean age was 32.92 years (Standard Deviation = 11. 81), with a minimum of 18 years and a maximum of 60. There were 48% males and 52% females, with a male to female ratio of 0.92. As to the level of education, 18% had elementary school education, 40% had secondary school education, and 42% had higher education level. 52% of patients were single, 46% were married and 2% were divorced. As to occupation, 52% were employed, 22% were unemployed, 24% were studying and 2% were retired. Patient's demographic characteristics are summarized in [Table 1].
Table 1: Demographic characteristics of patients

Click here to view

At the time of first presentation, 80% had patchy alopecia with less than 50% involvement (S1-S2), 12% had patchy alopecia with 50-99% involvement (S3-S4), and 8% had alopecia total is. The mean duration of hair loss prior to diagnosis was 69.28 days with figures ranging from 1 day to 400 days.

Alexithymia, anxiety and depression in the patient group

The mean score of alexithymia determined by TAS was 56.12 ± 14.42 in the patient group. Forty-two percent of patients scored positive for alexithymia.

The mean score of anxiety and depression was respectively 10.42 ± 3.49 and 8.96 ± 4.43. Anxiety and depression were detected respectively in 62% (N = 31) and in 38% of patients (N = 19).

Alexithymia, anxiety and depression in the control group

The mean score of alexithymia was 54 ± 14.78. The rate of alexithymic control subjects was 38%.The mean score of anxiety was 7.9 ± 3.48 and the mean score of depression was 7.18 ± 3.72. Anxiety was found in 34% of control subjects and depression in 20%.

Comparison between patient and control groups

No significant difference was found between patient and control groups (P = 0.683) in terms of alexithymia. The patient group had significantly more anxiety and depression than the control group (P = 0.005 and P = 0.047) as shown in [Figure 1].
Figure 1: Rate of alexithymia, anxiety and depression in the patient and control group

Click here to view

Factors correlated with alexithymia, anxiety and depression

When the participants with alexithymia and without alexithymia were compared in terms of gender, education or occupation, no statistically significant differences were found between groups. Alexithymia was not correlated to gender, education or occupation, neither in the patient nor in the control group.

In the patient group, the correlation between alexithymia and severity of AA was assessed, and no statistically significant correlation was found. There was no significant difference in depression between alexithymic and non-alexithymic patients. In terms of anxiety, alexithymic patients were more anxious than non-alexithymic patients (P = 0.019). The correlation of the different socio-demographic and clinical factors to alexithymia is summarized in [Table 2].
Table 2: Factors correlated with alexithymia

Click here to view

To further assess factors that influence alexithymia, we used stepwise linear regression. Anxiety was responsible for 14.7% of variation in alexithymia (P = 0.047).

Depression was significantly more frequent in women with AA compared to men (odds ratio [OR] =4.433, 95% confidence interval [CI]: 1.269-15.489, P = 0.016). It was found that unmarried patients with higher depression scores had a significantly higher risk for having AA compared to those who had lower depression scores (OR = 3.939, 95% CI: 1.168-13.281, P = 0.024). No relationship was found between the severity of AA and depression.

   Discussion Top


Alexithymia is defined as a deficit in the awareness and identification of emotional states. It is composed of four major factors: (1) Difficulty in identifying feelings and distinguishing between feelings and the bodily sensations of emotional arousal; (2) difficulty in describing feelings to other people; (3) constricted imaginative processes, as evidenced by a paucity of fantasies; and (4) a stimulus-bound, externally-oriented cognitive style. [19] In a review, Arck et al. [20] have found that there is solid evidence for a local neuroendocrine skin axis that operates as an important "brain-skin" connection, and they have established a fully functional peripheral equivalent of the systemic, stress-activated hypothalamic-pituitary-adrenal axis. [21],[22] Hence, it is not surprising that alexithymic individuals, who fail to cope with stress, are at risk for the development of specific dermatologic diseases.

Few studies have focused on the relationship between AA and alexithymia. [23] Several authors, [11],[24] have shown that a majority of patients with AA are alexithymic compared with controls. They found that AA tends to be associated with high avoidance in attachment relationships, high alexithymic characteristics, and poor social support. However, in our study, there was no significant difference between AA patients and controls in terms of alexithymia prevalence. Nevertheless, overall alexithymia rate in patients and controls was high: 42% in the patient group and 38% in the control group. Indeed, studies on alexithymia in the Mediterranean region seem to show elevated levels in the general population. [25]

People of Mediterranean origin are more likely to use somatizing and to convey emotional information through body language in order to communicate distress. [26] On the contrary, prevalence of alexithymia amongst Northern Europeans is relatively low, between 9.9 and 13. [27],[28]

This difference might be explained by cultural aspects. Culture can influence the experience and expression of emotion, and because alexithymia is primarily characterized by emotion identification and communication, culture is likely to influence alexithymia severity. [29] A recent study hypothesized that cultural differences in alexithymia may be explained by culturally based variations in the importance placed on emotions. [30]

Anxiety and depression

AA has been associated with an increased prevalence of certain psychiatric disorders, particularly depression and anxiety, varying from 40% to 93%. [31],[32] The present study confirms these findings: anxiety (62%) and depression (38%) were significantly higher in the patient group in comparison with controls (P = 0.005 and P = 0.047). This implies that the effect of AA on patients is psychologically distressing. Our study supports the fact that AA is a condition of high psychological impact because it alters self-image leading to embarrassment, lack of self-confidence and lower self-esteem. [8]

In our study, unmarried patients showed significantly more signs of depression compared to healthy controls. This finding is consistent with a study from Egypt, [33] which showed that single patients with AA were more likely to develop psychiatric disorders. These results denote that un established social life in unmarried patients makes them worry about their future resulting in more psychological distress and psychiatric morbidity.

In our sample, the female patients are differentiated from males by higher levels of anxiety and depression. This finding is in accordance with previous studies that indicated a higher prevalence of psychiatric morbidity among women with dermatological disease, especially eczema, psoriasis, acne and AA. [34],[35] Some studies, [36],[37] have found that hair loss was a traumatic experience for both men and women, but more difficult to support and accept for female patients. Women are more concerned about their physical appearance and hair is an important part of it. [36] Thus, the negative psychological impact of AA may be due to the importance of hair loss and its impact on their appearance. In Tunisia, where Islamic customs prevail women try to cover their hair in case of AA. This observation was also made in Kuwaiti and Egyptian studies. [38]

Some studies, [33],[39] showed that psychiatric comorbidity was associated with the presence of multiple patches of AA. Patients with limited AA are able to cover the patches with their remaining hair and are therefore less likely to experience psychological problems such as anxiety and depression. [7]

The link between alexithymia, anxiety and depression

Previous studies have reported a connection between alexithymia, anxiety and depressive symptomatology, and it is well known that patients are prone to experiencing alexithymic features. [27],[40] Our study showed a positive correlation between alexithymia and anxiety. Moreover, our regression showed that anxiety was responsible for 14.7% of variation in alexithymia, suggesting that anxiety may underlie patient's difficulties to identify feelings as other authors have previously noted. [41] Due to the cross sectional design of our study, we cannot answer the question of whether alexithymia leads anxiety symptoms or contrarily anxiety symptoms lead to alexithymia.

Some authors conceptualized alexithymia as a stable personality trait reflecting a deficit in the cognitive processing of emotional information. [42] The differentiation of cases with alexithymia state or trait would be important because cognitive therapies could be more indicated on primary alexithymia as suggested by Jimerson et al. [43] and Sexton et al.[44] Finally, the causal relationship between negative emotional states such as depression and anxiety and AA is still to be determined: (1) Are these negative emotional states due to AA? (2) Might AA be caused or triggered by these psychiatric conditions? (3) Do AA and psychiatric conditions share a common ground of vulnerability?

Limitations of the study

There are some limitations to our study that should be taken into consideration. First, the sample size was relatively small. Secondly, the participants were recruited from a hospital service of general dermatology. Consequently, our patient sample may not be representative of all patients with AA. The strengths of this study are that not only alexithymia but also related psychiatric conditions such as anxiety and depression have been examined. This is the first Tunisian case control study on the subject.

   Conclusion Top

Our study shows a high prevalence of anxiety and depressive symptoms in AA patients. No significant differences have been found in alexithymia prevalence between the patient and the control group, but overall alexithymia prevalence was high. Thus, no definite conclusions can be drawn from our study as to a possible relationship between alexithymia and AA and more studies are needed on this subject, possibly taking into account intercultural differences of alexithymia. However, the high prevalence of anxiety and depressive symptoms suggests that a screening for psychiatric distress in all AA patients might be warranted.

   References Top

1.Safavi K. Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey. Arch Dermatol 1992;128:702.  Back to cited text no. 1
2.Muller SA, Winkelmann RK. Alopecia areata. an evaluation of 736 patients. Arch Dermatol 1963;88:290-7.  Back to cited text no. 2
3.Price VH, Colombe BW. Heritable factors distinguish two types of alopecia areata. Dermatol Clin 1996;14:679-89.  Back to cited text no. 3
4.Shapiro J. Alopecia areata. Update on therapy. Dermatol Clin 1993;11:35-46.  Back to cited text no. 4
5.Skinner RB Jr, Light WH, Bale GF, Rosenberg EW, Leonardi C. Alopecia areata and presence of cytomegalovirus DNA. JAMA 1995;273:1419-20.  Back to cited text no. 5
6.Arca E, Kurumlu Z. Etiopathogenesis, clinical features, and diagnosis in Alopecia areata. Derm 2003;2:83-9.  Back to cited text no. 6
7.Hunt N, McHale S. The psychological impact of alopecia. BMJ 2005;331:951-3.  Back to cited text no. 7
8.Williamson D, Gonzalez M, Finlay AY. The effect of hair loss on quality of life. J Eur Acad Dermatol Venereol 2001;15:137-9.  Back to cited text no. 8
9.Beard HO. Social and psychological implications of alopecia areata. J Am Acad Dermatol 1986;14:697-700.  Back to cited text no. 9
10.Firooz A, Firoozabadi MR, Ghazisaidi B, Dowlati Y. Concepts of patients with alopecia areata about their disease. BMC Dermatol 2005;5:1.  Back to cited text no. 10
11.Picardi A, Pasquini P, Cattaruzza MS, Gaetano P, Baliva G, Melchi CF, et al. Psychosomatic factors in first-ons et al opecia areata. Psychosomatics 2003;44:374-81.  Back to cited text no. 11
12.Poot F. Psychological consequences of chronic hair diseases. Rev Med Brux 2004;25:A286-8.  Back to cited text no. 12
13.Sifneos PE. The prevalence of 'alexithymic' characteristics in psychosomatic patients. Psychother Psychosom 1973;22:255-62.  Back to cited text no. 13
14.Clement JP, Darthout N, Nubukpo P. Guide pratique de psychogériatrie. 2 th ed. Paris: Masson Mediguide; 2006.  Back to cited text no. 14
15.Misery L, Rousset H. La pelade est-elle une maladie psychosomatique? 2001;22:274-9.  Back to cited text no. 15
16.Olsen EA, Hordinsky MK, Price VH, Roberts JL, Shapiro J, Canfield D, et al. Alopecia areata investigational assessment guidelines - Part II. National Alopecia Areata Foundation. J Am Acad Dermatol 2004;51:440-7.  Back to cited text no. 16
17.Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67:361-70.  Back to cited text no. 17
18.Zimmermann G, Quartier V, Bernard M, Salamin V, Maggiori C. The 20-item Toronto alexithymia scale: Structural validity, internal consistency and prevalence of alexithymia in a Swiss adolescent sample. Encephale 2007;33:941-6.  Back to cited text no. 18
19.Richards HL, Fortune DG, Griffiths CE, Main CJ. Alexithymia in patients with psoriasis: Clinical correlates and psychometric properties of the Toronto Alexithymia Scale-20. J Psychosom Res 2005;58:89-96.  Back to cited text no. 19
20.Arck PC, Slominski A, Theoharides TC, Peters EM, Paus R. Neuroimmunology of stress: Skin takes center stage. J Invest Dermatol 2006;126:1697-704.  Back to cited text no. 20
21.Ito N, Ito T, Kromminga A, Bettermann A, Takigawa M, Kees F, et al. Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J 2005;19:1332-4.  Back to cited text no. 21
22.Slominski A, Wortsman J. Neuroendocrinology of the skin. Endocr Rev 2000;21:457-87.  Back to cited text no. 22
23.Willemsen R, Haentjens P, Roseeuw D, Vanderlinden J. Alexithymia in patients with alopecia areata: Educational background much more important than traumatic events. J Eur Acad Dermatol Venereol 2009;23:1141-6.  Back to cited text no. 23
24.Cordan Yazici A, Baºterzi A, Tot Acar S, Ustünsoy D, Ikizoğlu G, Demirseren D, et al. Alopecia areata and alexithymia. Turk Psikiyatri Derg 2006;17:101-6.  Back to cited text no. 24
25.Sunay D, Baykir M, Ateº G, Ekºioğlu M. Alexithymia and acne vulgaris: A case control study. Psychiatry Investig 2011;8:327-33.  Back to cited text no. 25
26.Van Moffaert M, Vereecken A. Somatization of psychiatric illness in Mediterranean migrants in Belgium. Cult Med Psychiatry 1989;13:297-313.  Back to cited text no. 26
27.Honkalampi K, Hintikka J, Tanskanen A, Lehtonen J, Viinamäki H. Depression is strongly associated with alexithymia in the general population. J Psychosom Res 2000;48:99-104.  Back to cited text no. 27
28.Salminen JK, Saarijärvi S, Aärelä E, Toikka T, Kauhanen J. Prevalence of alexithymia and its association with sociodemographic variables in the general population of Finland. J Psychosom Res 1999;46:75-82.  Back to cited text no. 28
29.Le HN, Berenbaum H, Raghavan C. Culture and alexithymia: Mean levels, correlates, and the role of parental socialization of emotions. Emotion 2002;2:341-60.  Back to cited text no. 29
30.Dere J, Falk CF, Ryder AG. Unpacking Cultural Differences in Alexithymia: The Role of Cultural Values Among Euro-Canadian and Chinese-Canadian Students. J Cross Cult Psychol 2012;43:1297-312.  Back to cited text no. 30
31.Ruiz-Doblado S, Carrizosa A, García-Hernández MJ. Alopecia areata: Psychiatric comorbidity and adjustment to illness. Int J Dermatol 2003;42:434-7.  Back to cited text no. 31
32.Greenberg SI. Alopecia areata, a psychiatric survey. AMA Arch Derm 1955;72:454-7.  Back to cited text no. 32
33.Saleh HM, Abdallah M, Salem S, El-Sheshetawy RS, Abd El-Samei AM. Comparative Study of Psychiatric Morbidity and Quality of Life in Psoriasis, Vitiligo and Alopecia Areata. Egypt Dermatol Online J 2008;4:2.  Back to cited text no. 33
34.Welsh N, Guy A. The lived experience of alopecia areata: A qualitative study. Body Image 2009;6:194-200.  Back to cited text no. 34
35.Ghajarzadeh M, Ghiasi M, Kheirkhah S. Depression and quality of life in Iranian patients with Alopecia Areata. Iran J Dermatol 2011;14:140-3.  Back to cited text no. 35
36.Cash TF, Price VH, Savin RC. Psychological effects of androgenetic alopecia on women: Comparisons with balding men and with female control subjects. J Am Acad Dermatol 1993;29:568-75.  Back to cited text no. 36
37.Cash TF. The psychology of hair loss and its implications for patient care. Clin Dermatol 2001;19:161-6.  Back to cited text no. 37
38.Al-Mutairi N, Eldin ON. Clinical profile and impact on quality of life: Seven years experience with patients of alopecia areata. Indian J Dermatol Venereol Leprol 2011;77:489-93.  Back to cited text no. 38
[PUBMED]  Medknow Journal  
39.Jowett S, Ryan T. Skin disease and handicap: An analysis of the impact of skin conditions. Soc Sci Med 1985;20:425-9.  Back to cited text no. 39
40.Honkalampi K, Saarinen P, Hintikka J, Virtanen V, Viinamäki H. Factors associated with alexithymia in patients suffering from depression. Psychother Psychosom 1999;68:270-5.  Back to cited text no. 40
41.Parker JD, Bagby RM, Taylor GJ. Alexithymia and depression: Distinct or overlapping constructs? Compr Psychiatry 1991;32:387-94.  Back to cited text no. 41
42.Taylor GJ. Recent developments in alexithymia theory and research. Can J Psychiatry 2000;45:134-42.  Back to cited text no. 42
43.Jimerson DC, Wolfe BE, Franko DL, Covino NA, Sifneos PE. Alexithymia ratings in bulimia nervosa: Clinical correlates. Psychosom Med 1994;56:90-3.  Back to cited text no. 43
44.Sexton MC, Sunday SR, Hurt S, Halmi KA. The relationship between alexithymia, depression, and axis II psychopathology in eating disorder inpatients. Int J Eat Disord 1998;23:277-86.  Back to cited text no. 44

What is new?
In our study, AA patients were not more alexythymic than controls. Prevalence of alexithymia was high in patient and control group, which might be linked to the Mediterranean origin of the population.


  [Figure 1]

  [Table 1], [Table 2]

This article has been cited by
1 Prevalence and Odds of Depressive and Anxiety Disorders and Symptoms in Children and Adults With Alopecia Areata
Sophie Lauron, Camille Plasse, Marion Vaysset, Bruno Pereira, Michel D’Incan, Fabien Rondepierre, Isabelle Jalenques
JAMA Dermatology. 2023;
[Pubmed] | [DOI]
2 The burden of alopecia areata: A scoping review focusing on quality of life, mental health and work productivity
Anastasiya Muntyanu, Sofianne Gabrielli, Jeffrey Donovan, Melinda Gooderham, Lyn Guenther, Sameh Hanna, Charles Lynde, Vimal H. Prajapati, Marni Wiseman, Elena Netchiporouk
Journal of the European Academy of Dermatology and Venereology. 2023;
[Pubmed] | [DOI]
3 Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019
Hyeokjoo Jang, Seoyeon Park, Min Seo Kim, Dong Keon Yon, Seung Won Lee, Ai Koyanagi, Karel Kostev, Jae Il Shin, Lee Smith
European Journal of Clinical Investigation. 2023;
[Pubmed] | [DOI]
4 Prevalence and implications of type D personality in patients with alopecia areata: A marker of quality-of-life impairment and mood status disturbances, a comparative study
Manuel Sánchez-Díaz, Trinidad Montero-Vílchez, Carlos Cuenca-Barrales, Alejandro Molina-Leyva, Salvador Arias-Santiago
Journal of the European Academy of Dermatology and Venereology. 2022;
[Pubmed] | [DOI]
5 The associated burden of mental health conditions in alopecia areata: a population-based study in UK primary care
Abby E. Macbeth, Susan Holmes, Matthew Harries, Wing Sin Chiu, Christos Tziotzios, Simon Lusignan, Andrew G. Messenger, Andrew R. Thompson
British Journal of Dermatology. 2022;
[Pubmed] | [DOI]
6 Two-way association between alopecia areata and sleep disorders: A systematic review of observational studies
Syeda Tayyaba Rehan, Zayeema Khan, Hussain Mansoor, Syed Hasan Shuja, Mohammad Mehedi Hasan
Annals of Medicine and Surgery. 2022; : 104820
[Pubmed] | [DOI]
7 Phase 2 randomized, dose-ranging trial of CTP-543, a selective Janus Kinase inhibitor, in moderate-to-severe alopecia areata
Brett King, Natasha Mesinkovska, Paradi Mirmirani, Suzanne Bruce, Steve Kempers, Emma Guttman-Yassky, Janet L. Roberts, Amy McMichael, Maria Colavincenzo, Colleen Hamilton, Virginia Braman, James V. Cassella
Journal of the American Academy of Dermatology. 2022;
[Pubmed] | [DOI]
8 Total alopecia and vascular malformation: a random association or a prognostic factor?
Igor Yu. Golousenko, Anton M. Solovyov, Fedor A. Solovev
Consilium Medicum. 2022; 24(8): 520
[Pubmed] | [DOI]
9 Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels
Haifeng Wang, Lifang Pan, Yanfeng Wu
Frontiers in Immunology. 2022; 13
[Pubmed] | [DOI]
10 Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis
Marije van Dalen, Kirsten S. Muller, Johanna M. Kasperkovitz-Oosterloo, Jolanda M. E. Okkerse, Suzanne G. M. A. Pasmans
Frontiers in Medicine. 2022; 9
[Pubmed] | [DOI]
11 Quality of Life and Mood Status Disturbances in Cohabitants of Patients with Alopecia Areata: A Cross-Sectional Study in a Spanish Population
Manuel Sánchez-Díaz, Pablo Díaz-Calvillo, Clara-Amanda Ureña-Paniego, Alejandro Molina-Leyva, Salvador Arias-Santiago
International Journal of Environmental Research and Public Health. 2022; 19(23): 16323
[Pubmed] | [DOI]
12 Burden of Disease in Alopecia Areata: A Canadian Online Survey of Patients and Caregivers (Preprint)
Anthony Justin Gilding, Nhung Ho, Elena Pope, Cathryn Sibbald
JMIR Dermatology. 2022;
[Pubmed] | [DOI]
13 An evaluation of anxiety disorder and emotion regulation difficulty in children and adolescents with alopecia areata
DilsadYildiz Miniksar, Emine Çölgeçen, MehmetAkif Cansiz
Indian Journal of Dermatology. 2022; 67(3): 313
[Pubmed] | [DOI]
14 Frequência de sintomas de ansiedade e depressão, qualidade de vida e percepção da doença em portadores de alopecia areata
Letícia George Camalionte, Maria Rita Polo Gascón, Ana Carolina de Oliveira, Jorge Simão do Rosário Casseb
Revista da Sociedade Brasileira de Psicologia Hospitalar. 2021; 24(2): 48
[Pubmed] | [DOI]
15 Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3ß/ß-Catenin Signaling Pathway
Yun Hee Lee, Hui-Ji Choi, Ji Yea Kim, Ji-Eun Kim, Jee-Hyun Lee, So-Hyun Cho, Mi-Young Yun, Sungkwan An, Gyu Yong Song, Seunghee Bae
Journal of Microbiology and Biotechnology. 2021; 31(7): 933
[Pubmed] | [DOI]
16 Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review
Arash Mostaghimi, Lynne Napatalung, Vanja Sikirica, Randall Winnette, Jason Xenakis, Samuel H. Zwillich, Boris Gorsh
Dermatology and Therapy. 2021; 11(3): 867
[Pubmed] | [DOI]
17 Engineered extracellular vesicle mimetics from macrophage promotes hair growth in mice and promotes human hair follicle growth
Ramya Lakshmi Rajendran, Prakash Gangadaran, Mi Hee Kwack, Ji Min Oh, Chae Moon Hong, Arunnehru Gopal, Young Kwan Sung, Jaetae Lee, Byeong-Cheol Ahn
Experimental Cell Research. 2021; 409(1): 112887
[Pubmed] | [DOI]
18 An Evaluation of the PERMA Model as a Framework for Reducing Psychiatric Comorbidity in Individuals With Alopecia Areata
Garrett E. Huck, Emre Umucu, Shaina Shelton, Dana Brickham, Susan Smedema
European Journal of Health Psychology. 2021;
[Pubmed] | [DOI]
19 Impact of cyclosporin treatment on health-related quality of life of patients with alopecia areata
Vivien Wai Yun Lai, Gang Chen, Rodney Sinclair
Journal of Dermatological Treatment. 2021; 32(2): 250
[Pubmed] | [DOI]
20 Efficacy and predictive factors of cyclosporine A in alopecia areata: a systematic review with meta-analysis
Husein Husein-ElAhmed, Martin Steinhoff
Journal of Dermatological Treatment. 2021; : 1
[Pubmed] | [DOI]
21 Alexithymia And Behçet’s Disease
Konuralp Tip Dergisi. 2021;
[Pubmed] | [DOI]
22 Effectiveness of QR678 and QR678 Neo ® with intralesional corticosteroid vs. intralesional corticosteroid alone in the treatment of alopecia areata –A randomized, comparative, prospective study
Debraj Shome, Rinky Kapoor, Komal Doshi, Ghanshyam Patel, Sapna Vadera, Vaibhav Kumar
Journal of Cosmetic Dermatology. 2021;
[Pubmed] | [DOI]
23 Epidemiology, management and the associated burden of mental health illness, atopic and autoimmune conditions, and common infections in alopecia areata: protocol for an observational study series
Matthew Harries, Abby E Macbeth, Susan Holmes, Andrew R Thompson, Wing Sin Chiu, William Romero Gallardo, Andrew G Messenger, Christos Tziotzios, Simon de Lusignan
BMJ Open. 2021; 11(11): e045718
[Pubmed] | [DOI]
24 Lichen Planopilaris in Women
Sydney C. Larkin, Hafsa M. Cantwell, Reese L. Imhof, Rochelle R. Torgerson, Stanislav N. Tolkachjov
Mayo Clinic Proceedings. 2020; 95(8): 1684
[Pubmed] | [DOI]
25 The Potential Role of Nutraceuticals as an Adjuvant in Breast Cancer Patients to Prevent Hair Loss Induced by Endocrine Therapy
Giorgio Dell’Acqua, Aleksander Richards, M. Julie Thornton
Nutrients. 2020; 12(11): 3537
[Pubmed] | [DOI]
26 Investigating the beneficial experiences of online peer support for those affected by alopecia: an interpretative phenomenological analysis using online interviews
L.L. Iliffe, A.R. Thompson
British Journal of Dermatology. 2019; 181(5): 992
[Pubmed] | [DOI]
27 Alopecia areata: Viele Faktoren spielen eine Rolle
Uwe Gieler
Kompass Dermatologie. 2019; 7(4): 203
[Pubmed] | [DOI]
28 Psycho-emotional conditions of patients with non-cicatrazing alopecia (circumsribed, androgenetic)
A. N. Mareeva, I. N. Kondrakhina
Vestnik dermatologii i venerologii. 2015; 91(6): 50
[Pubmed] | [DOI]


Print this article  Email this article
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (472 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

    Materials and Me...
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded108    
    Comments [Add]    
    Cited by others 28    

Recommend this journal