| E-CASE REPORT |
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| Year : 2014 | Volume
: 59
| Issue : 2 | Page : 209 |
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Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus
Li Xuan, Yang Baohua, Baohua Lan
Department of Dermatology, Chengdu Second People's Hospital, Chengdu, P.R. China
Correspondence Address:
Yang Baohua
Department of Dermatology, Chengdu Second People's Hospital, Qingyun South Street 10, Chengdu 610017, People's Republic of China
P.R. China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0019-5154.127710
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A 26-year-old Chinese male consulted with the team regarding his alopecia areata and vitiligo for which previous treatment was ineffective. The patient, a homosexual man, denied having a history of drug abuse and of blood transfusion. No member of his family had vitiligo or alopecia. Laboratory studies revealed that the serum for anti-human immunodeficiency virus (HIV) antibody was positive. The patient's CD4 lymphocyte count and CD4/CD8 ratio were both strikingly low (20 cells/mL and 0.04), but no other complaints or opportunistic infections were reported. One month after antiretroviral therapy, the patient's alopecia areata dramatically improved, but no evident improvement in his vitiligo was found. This case is a very rare case of alopecia areata and vitiligo associated with HIV infection that might be attributed to the generation and maintenance of self-reactive CD8+ T-cells due to chronic immune activation with progressive immune exhaustion in HIV infection. |
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