Indian Journal of Dermatology
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Year : 2014  |  Volume : 59  |  Issue : 1  |  Page : 56-59

Characteristics of mixed type basal cell carcinoma in comparison to other BCC subtypes

1 Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Dermatology, Shahid Beheshti University of Medical Science, Tehran, Iran
4 Department of Internal Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran

Correspondence Address:
A Abbasi
Department of Pathology, Tehran University of Medical Sciences, Tehran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.123496

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Background: There are limited data exploring the characteristics of mixed type basal cell carcinoma (BCC). Objectives: To explore different characteristics of mixed type BCC. Design: Cross sectional study. Materials and Methods: 825 patients with BCC enrolled in this study. Results: Among 825 patients, 512 (62%) were male. Three hundred and fifty five (43%) presented with nodular subtype, 267 (32.4%) with mixed subtype, 25 with superficial and the 178 remaining presented with other subtypes. Four hundred and eighty three (58.6%) of the lesions were on the face, 243 (29.5%) on scalp, 52 (6.3%) on ears, 20 (2.4%) on neck, 15 (1.8%) on trunk and 12 (1.4%) on extremities. Anatomic distribution of mixed type was as follows: 137 on face, (51.4%), 100 (37.3%) on scalp, 19 (7%) on ear, 6 (2.1%) on neck, 4 (1.5%) extremity and 1 (0.7%) on trunk, which the difference from non mixed types was statistically significant (P = 0.002). The mean diameter of the mixed types and non mixed type BCCs were significantly different (2.7 ± 2.1 cm vs. 2.2 ± 1.6 cm; P = 0.01. The prevalence of necrosis in mixed type BCC was two times higher than non mixed type BCCs (OR = 2.3, CI 95% 1.3-3.9, P = 0.001). The most frequent combined subtypes were nodular-infiltrative (P < 0.001). Conclusion: Mixed type BCC has differences with other BCC subtypes in anatomical distribution and tumor diameter. Indeed, mixed type BCCs are frequently composed of aggressive subtypes than nonaggressive subtypes.

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