Indian Journal of Dermatology
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Year : 2013  |  Volume : 58  |  Issue : 6  |  Page : 492

Bullous systemic lupus erythematosus

1 Department of Dermatology, University College of Medical Sciences, Dilshad Garden, Delhi, India
2 Department of Pathology, University College of Medical Sciences, Dilshad Garden, Delhi, India

Correspondence Address:
Chander Grover
Assistant Professor, 420-B, Pocket 2, Mayur Vihar, Phase-1, Delhi - 110 091
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.119973

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Bullous Systemic Lupus Erythematosus (BSLE) is a rare manifestation of Systemic Lupus Erythematosus (SLE), characterized histologically by subepidermal bullae with predominantly neutrophilic infiltrate and immunoglobulin (IgG, IgA, IgM) and C3 deposition at the basement membrane zone. Often associated is a heterogeneous profile of autoimmunity to components of type VII collagen. It needs to be differentiated from other subepidermal bullous diseases in view of potentially associated systemic manifestations of SLE. We report a 39-year-old lady who presented with an extensive vesicobullous eruption on face, neck, trunk, and mucosa. She was also found to have photosensitivity, significant anemia, and high antibody titers confirming SLE. Routine histopathology and immunoflorescence studies suggested BSLE and she responded favorably to dapsone. The importance of clinical and histopathological findings in confirming a diagnosis of BSLE along with the very encouraging response to dapsone therapy is highlighted.

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