| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 58
| Issue : 1 | Page : 18-21 |
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Evaluation of cutaneous drug reactions in patients visiting out patient departments of Indira Gandhi Government Medical College and Hospital (IGGMC and H), Nagpur
Sachin Hiware1, Meena Shrivastava1, Dharmendra Mishra2, Jayesh Mukhi2, Gaurav Puppalwar1
1 Department of Pharmacology, Indira Gandhi Government Medical College and Hospital, Nagpur, India
2 Department of Skin and V.D., Indira Gandhi Government Medical College and Hospital, Nagpur, India
Correspondence Address:
Sachin Hiware
Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur - 440018
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0019-5154.105279
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Objectives: To detect cutaneous drug reactions through spontaneous reporting system in IGGMCand H, Nagpur and analyze them using standard assessment scales. Materials and Methods: An observational, prospective study was performed in patients attending dermatology OPD of IGGMC and H, Nagpur from 1 st June 05 to 31 st May 09. Patients were examined for cutaneous drug reactions (CDRs) by spontaneous Adverse Drug Reaction reporting system. Results: Among 2693 total ADRs reported, 872 (33.04%) were CDRs. Antimicrobials (55.5%) were the main drugs involved followed by NSAIDs (18.56%) and steroids (12.61%). Maculopapular rash (37.73%) followed by fixed drug eruption (17.2%) and urticaria (14.56%) were the most frequently observed CDRs. The common drugs causing CDRs were cotrimoxazole (20.41%), topical steroids (betamethasone), ibuprofen (7.91%), ampicillin (6.54%), diclofenac (4.7%) and iron dextran (3.44%). Conclusion : It was observed that commonly used drugs like antibiotics and NSAIDs lead to maximum number of CDRs. Hence strict vigilance is required while using them. This study provides a database of ADRs due to common drugs, which will help clinicians in safe use of these drugs. |
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