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Year : 2012  |  Volume : 57  |  Issue : 6  |  Page : 503
Angina bullosa hemorrhagica: Report of two cases

1 Department of Oral Medicine and Radiology, IDST Dental College, Kadrabad, Modinagar, Uttar Pradesh, India
2 Department of Oral Medicine and Radiology, Faculty of dentistry, Jamia Milia Islamia, New Delhi, India
3 Department of Oral Medicine and Radiology, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India

Date of Web Publication1-Nov-2012

Correspondence Address:
Shalu Rai
Professor and Head, Department of Oral Medicine and Radiology, Institute of Dental Studies and Technologies, Kadrabad, Modinagar, Uttar Pradesh - 201201
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.103083

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Angina bullosa hemorrhagic (ABH) describes the acute and sometimes painful onset of oral blood-filled vesicles and bullae, not attributable to blood dyscrasia, vesiculobullous disorders, systemic diseases or other known causes. The haemorrhagic bullae spontaneously burst after a short time resulting in ragged, often painless, superficial erosions that heal spontaneously within 1 week without scarring. Trauma appears to be the most common identifiable precipitating factor, but the essential tissue defect is yet unidentified. This paper presents two cases of ABH with the aim to create awareness regarding occurrence of this lesion, thus avoiding any misdiagnosis.

Keywords: Angina bullosa hemorrhagica, blood blisters, soft palate, trauma

How to cite this article:
Rai S, Kaur M, Goel S. Angina bullosa hemorrhagica: Report of two cases. Indian J Dermatol 2012;57:503

How to cite this URL:
Rai S, Kaur M, Goel S. Angina bullosa hemorrhagica: Report of two cases. Indian J Dermatol [serial online] 2012 [cited 2022 Nov 26];57:503. Available from:

What was known? Angina bullosa hemorrhagic is an example of traumatic lesion characterized by oral blood-filled vesicles and bullae, not attributable to blood dyscrasia, vesiculobullous disorders, systemic diseases or other known causes. The haemorrhagic bullae spontaneously burst after a short time resulting in ragged, often painless, superficial erosions that heal spontaneously within 1 week without scarring.

   Introduction Top

Traumatic lesions of the oral mucosa occur frequently in clinical practice. Most of them represent acute or chronic injuries of soft tissues arising from incorrect hygienic procedures. Only sometimes do they become artefactual problems, burns and posttraumatic mucosal lesions. However, their origin, location and clinical signs may considerably differ. They can appear atypically, and sometimes may present bizarre characteristics. [1],[2] Angina bullosa hemorrhagica (ABH) is an example of oral mucosal traumatic lesion caused by various mechanical stimuli, especially by ingestion of hard and crispy food. [2],[3] It is a benign phenomenon, usually occurring on soft palate of middle aged individuals, that is characterized by the sudden appearance of a blood blister on the oral mucosa in the absence of an identifiable cause or systemic disorder. This condition was first described in 1933 as traumatic oral hemophlyctenosis. Badham, first used the currently accepted term ABH in 1967. [2],[3] The lesions of ABH may be indistinguishable from blood blisters related to thrombocytopenia; however, blood tests and the absence of areas of ecchymosis, epistaxis, or gingival bleeding are helpful signs to rule it out. [2],[3],[4],[5]

The awareness of ABH in the field of dermatology and dentistry is very much necessary to avoid misdiagnosis, since this condition spontaneously rupture and heal without any treatment. This case report creates awareness regarding occurrence of the lesion especially on soft palate.

   Case Reports Top

Case 1

A 40-year-old man patient presented to the Oral Medicine and Radiology Department with chief complaint of decayed teeth. He was a non smoker and non alcoholic. His dental and family history was unremarkable. On intraoral examination, a blood blister was present on the soft palate, which had almost converted into an ulcer [Figure 1]. The patient was unaware of the same lesion and therefore gave no significant history regarding the same. He was also unable to recall any similar previous episodes in the past. Patient was then subjected for routine blood examinations, which yielded normal results. On the basis of clinical appearance and the history, a provisional diagnosis of ABH was made. Incisional biopsy of the lesion was done to rule out pemphigus, bullous pemphigoid, bullous lichen planus etc. Hematoxylin and Eosin stained sections revealed hemorrhagic areas with mild inflammatory cell infiltrate. No treatment was carried out and the lesion spontaneously healed without scarring within 3 days.
Figure 1: Blood blister on the soft palate in Case 1

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Case 2

Another 45-year-old man patient presented with the chief complaint of blister on the palate, since day one. He developed the same soon after taking meal, the previous night. On examination, a blood filled blister was present on the soft palate, which was painless, raised, round, dark red in color and measured around 1 cm in diameter [Figure 2]. Routine blood examination, which included platelet count, bleeding time, clotting time, prothrombin time, WBC count and blood sugar random were within normal limits. This lesion was also diagnosed as ABH. H and E stained sections revealed non-specific inflammatory features. The lesion persisted for few hours and then spontaneously ruptured and eventually healed in next 2 days.
Figure 2: Painless, round blood filled blister on palate in case 2

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   Discussion Top

Traditionally, ABH is an idiopathic condition. Causes that have been mentioned in the literature are related to the minor trauma of hot foods, restorative dentistry, periodontal therapy, dental injections of anesthetics, steroid inhalers and chlorhexidine gluconate mouthrinse. [6],[7],[8] Diabetes mellitus may be a contributing factor in developing ABH. Some authors suggest mild trauma as the causative agent in ABH to break the epithelial-connective-tissue junction, causing bleeding of superficial capillaries and resulting in the formation of a subepithelial hemorrhagic bullae. [2],[3],[8],[9]

The blisters last only few minutes and then spontaneously rupture, leaving a shallow ulcer that heals without scarring, discomfort or pain, as seen in both the present cases. The lesions reach an average size of 1-3 cm in diameter. The soft palate is the most commonly affected site. Occasional lesions have been reported in the buccal mucosa and tongue. Similar lesions in other mucous membranes or the skin have not been reported. Considering the fragility of soft palate mucosa, it is easy to speculate that submucosal hemorrhage may be elicited even by subclinical trauma. It is also noteworthy that mastication significantly increases the blood flow rate in the soft palate via parasympathetic reflux vasodilatation. Collectively, the soft palate is easily injured during mastication of hard and crispy food and is therefore prone to ABH. [2],[3],[9],[10]

The diagnosis of ABH essentially is clinical; however, the cases in which a biopsy has being taken, the microscopic examination reveals a subepithelial bulla filled with blood and an underlying mild and nonspecific mononuclear inflammatory cell infiltrate, that generally is limited to the region of the lamina propria. Occasionally, neutrophils may be seen. [2],[11],[12] Direct immunofluorescence staining for IgA, IgG, IgM and fibrin is negative and can demonstrate equivocal staining along the basement membrane zone for Complement Component 3 Biopsy and immunofluorescence studies may be useful to exclude other blistering diseases. [11],[12]

Differential diagnosis must include pemphigus, bullous pemphigoid, bullous lichen planus, dermatitis herpetiformis, epidermolysis bullosa, oral amyloidosis and thrombocytopenia. No treatment is required for ABH because the blood blisters spontaneously rupture and heal. Use of benzydamine hydrochloride provides symptomatic relief. [2],[3],[10]

   References Top

1.Tolentino ES, Baldo VO, Dreibi VM, Chinallato LE. Atypical lesion on soft palate: A curious case. Int. J. Odontostomat. 2010;4:9-12.  Back to cited text no. 1
2.Horie N, Kawano R, Inaba J. Angina bullosa hemorrhagica of the soft palate: A clinical study of 16 cases. J Oral Sci 2008;50:33-6.  Back to cited text no. 2
3.Deblauwe BM, van der Waal I. Blood blisters of the oral mucosa (angina bullosa haemorrhagica). J Am Acad Dermatol 1994;31(2 Pt 2):341-4.  Back to cited text no. 3
4.Pahl C, Yarrow S, Steventon N, Saeed NR, Dyar O. Angina bullosa haemorrhagica presenting as acute upper airway obstruction. Br J Anaesth 2004;92:283-6.  Back to cited text no. 4
5.Grinspan D, Abulafia J, Lanfranchi H. Angina bullosa hemorrhagica. Int J Dermatol 1999;38:525-8.  Back to cited text no. 5
6.Yamamoto K, Fujimoto M, Inoue M, Maeda M, Yamakawa N, Kirita T. Angina bullosa hemorrhagica of the soft palate: Report of 11 cases and literature review. J Oral Maxillofac Surg 2006;64:1433-6.  Back to cited text no. 6
7.Garlick JA, Calderon S. Oral blood blisters in angina bullosa haemorrhagica secondary to trauma of eating and dental injection. Br Dent J 1988;165:286-7.  Back to cited text no. 7
8.High AS, Main DM. Angina bullosa haemorrhagica: A complication of long term steroid inhaler use. Br Dent J 1988;165:176-9.  Back to cited text no. 8
9.De las Heras ME, Moreno R, Núñez M, Gómez MI, Ledo A. Angina bullosa hemorrhagica. J Dermatol 1996;23:507-9.  Back to cited text no. 9
10.Edwards S, Wilkinson JD, Wojnarowska F. Angina bullosa haemorrhagica--a report of three cases and review of the literature. Clin Exp Dermatol 1990;15:422-4.  Back to cited text no. 10
11.Stephenson P, Scully C, Prime SS, Daly HM. Angina bullosa haemorrhagica: Lesional immunostaining and haematological findings. Br J Oral Maxillofac Surg 1987;25:488-91.  Back to cited text no. 11
12.Stephenson P, Lamey PJ, Scully C, Prime SS. Angina bullosa haemorrhagica: Clinical and laboratory features in 30 patients. Oral Surg Oral Med Oral Pathol 1987;63:560-5.  Back to cited text no. 12

What is new? Most of the general practitioners are unaware of this lesion leading to misdiagnosis and patient is subjected to unnecessary treatment since this condition spontaneously rupture and heal without any treatment. This case report creates awareness regarding occurrence of the lesion especially on soft palate.


  [Figure 1], [Figure 2]

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