Indian Journal of Dermatology
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Year : 2011  |  Volume : 56  |  Issue : 6  |  Page : 763-765

Dress syndrome with sepsis, acute respiratory distress syndrome and pneumomediastinum

1 Department of Pediatric Medicine, Institute of Child Health, Kolkata, India
2 Department of Pediatric Dermatology, Institute of Child Health, Kolkata, India

Correspondence Address:
Prabhas Prasun Giri
C-1, Anandan, 173, Sarat Ghosh Garden Road, Dhakuria, Kolkata-31
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.91850

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Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome reflects a serious hypersensitivity reaction to drugs, and is characterized by skin rash, fever, lymph node enlargement, and internal organ involvement. So far, numerous drugs such as sulfonamides, phenobarbital, sulfasalazine, carbamazepine, and phenytoin have been reported to cause DRESS syndrome. We report a case of a 10-year-old girl who developed clinical manifestations of fever, rash, lymphadenopathy, hypereosinophilia, and visceral involvement (hepatitis and pneumonitis) after taking phenobarbital for seizures, with subsequent development of sepsis, acute respiratory distress syndrome (ARDS) and spontaneous air leak syndrome (pnemothorax and pneumomediastinum). She was put on steroids and various antibiotics and was ventilated, but ultimately succumbed to sepsis and pulmonary complications.

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