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Table of Contents 
Year : 2011  |  Volume : 56  |  Issue : 5  |  Page : 578-580
Squamous cell carcinoma of supraglottic larynx with metastasis to all five distal phalanges of left hand

1 Department of Radiotherapy and Regional Cancer Centre (RCC), PGIMER, Chandigarh, India
2 Department of Pathology PGIMER, Chandigarh, India

Date of Web Publication4-Nov-2011

Correspondence Address:
Narendra Kumar
Department of Radiotherapy and RCC, PGIMER, Sector 12, Chandigarh - 160 012
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.87161

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Subcutaneous metastasis from carcinoma larynx is a rare presentation and to the phalynx is the rarest. We herein describe a case report of carcinoma supraglottic larynx, which is involving all five distal phalanges of left hand with simultaneous metastases to lung and liver. Acrometastasis is an unusual presentation, which might mimic an infectious or inflammatory pathology. The brief report highlights the importance of clinical awareness of metastatic dissemination to unusual sites in the face of increasing cancer survivorship.

Keywords: Acrometastasis, phalanges, suproglottic larynx, squamous cell carcinoma of head and neck

How to cite this article:
Kumar N, Bera A, Kumar R, Ghoshal S, Angurana SL, Srinivasan R. Squamous cell carcinoma of supraglottic larynx with metastasis to all five distal phalanges of left hand. Indian J Dermatol 2011;56:578-80

How to cite this URL:
Kumar N, Bera A, Kumar R, Ghoshal S, Angurana SL, Srinivasan R. Squamous cell carcinoma of supraglottic larynx with metastasis to all five distal phalanges of left hand. Indian J Dermatol [serial online] 2011 [cited 2022 Jul 2];56:578-80. Available from:

   Introduction Top

Distant metastases in laryngeal carcinoma are rare and when present, most commonly involve the lung. [1] We report a rare case of laryngeal carcinoma presenting with metastases to all five distal phalanges of left hand with simultaneous metastasis to multiple sites after 2 years of receiving radical chemo-radiation to the head and neck region with complete local control.

   Case Report Top

A 55-year-old man was diagnosed as a case of carcinoma supraglottic larynx (stage T4N1M0) in August 2007. Histopathology of primary site was squamous cell carcinoma, and fine needle aspiration cytology (FNAC) of neck node was also squamous cell carcinoma. The patient was planned for radical chemo-radiation after complete clinical and investigative workup. He received external beam radiotherapy (EBRT) using 6 MV Photon to a total dose of 66 Gy in 33 fractions over six and half weeks (from 07-08-2007 to 22-08-2007) with concurrent cisplatin chemotherapy at 3 weeks interval. At 1 month after completion of treatment, patient was free from disease both clinically and on direct laryngoscopic examination and kept on regular follow up. Patient presented after 2 years with complaints of swelling on tip of all fingers and nail bed of left hand [Figure 1], multiple subcutaneous nodule in upper and lower limb, and loss of appetite with significant weight loss. An FNAC from tip of fingers and subcutaneous swelling was suggestive of metastatic carcinoma [Figure 2]. Contrast-enhanced computed tomography (CECT) of chest, abdomen, and pelvis, revealed metastasis in bilateral lungs and liver [Figure 3]a-b. Local examination of neck and direct laryngoscopic examination was suggestive of no evidence of disease (NED)/essentially normal. In view of his very poor general condition and widespread dissemination of disease, the patient was offered palliative treatment only and he died within 2 months at home.
Figure 1: Metastatic swelling of all five distal phalanx of left hand

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Figure 2: Photomicrograph showing cluster of malignant cells with extensive necrosis and apoptosis in background (Hematoxylin and eosin stain, original ×400)

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Figure 3: (a) Multiple bilateral lungs metastases, (b) Multiple liver metastases

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   Discussion Top

The incidence of distant metastases in squamous cell carcinoma of head and neck (SCCHN) approaches 20%-25%. The most common sites of metastases are lung (70%-75%), liver (17%-38%), and bone (23%-44%). [2],[3],[4] Skin metastases has been reported to occur in 1%-2% of patients with SCCHN and account for fewer than 10% of all distant metastases. [5] Other malignancies associated with skin metastases include carcinoma of bronchus, breast, colon, and kidney. Cancers arising in the oral cavity are the commonest head and neck cancers metastasizing to skin. [6] Review of the surgical literature revealed only seven previously reported cases of cutaneous metastases from squamous cell carcinoma of the larynx. [7],[8]

The site of skin metastases include neck, chest, scalp, face, lips, axilla, areola, back, arms, and digits, with the most common being the neck and chest. [7],[9] It is evident on literature search that multiple metastases from a laryngeal carcinoma involving all five distal phalanges, bilateral lung, liver and multiple subcutaneous nodule in upper and lower extremities, as described above is not reported till date.

The exact mechanism of skin metastases in SCCHN is incompletely understood. Several hypotheses have been postulated. The skin metastases may evolve through three possible mechanisms, direct spread, local spread, and distant spread. [10] Direct extension is due to contiguous spread via tissue planes. Local spread can be ascribed to spread through dermal lymphatics with resultant implantation in the skin. Distant metastases are the result of hematogenous spread. This route of hematogenous spread could be either through pulmonary circulation or bypassing pulmonary circulation via azygous and vertebral venous plexus. [11] In the indexed case, the acrometastasis is most likely due to spread by hematogenous route via pulmonary circulation as the patient has multiple bilateral lung, liver, multiple subcutaneous nodules along with cutaneous phalangeal metastasis.

Cutaneous metastases from laryngeal carcinoma may present as non-tender firm nodules, as sclerodermoid lesions or may mimic an inflammatory process. [6] The diagnosis should be confirmed by cytology or histopathological examination of the lesions and in this case it was confirmed with a positive cytology report.

Treatment is essentially aimed at providing symptomatic relief and improving the quality of life. In solitary acral metastases, amputation of finger or localized radiation is recommended. [12] In the indexed case, the patient presented with disseminated disease with involvement of all five distal phalanges, so further treatment offered was essentially palliative as numerous metastases developed rapidly at different sites and because of poor general condition.

The prognosis for these patients remains dismal after diagnosis of distant cutaneous metastases. The indexed case, at initial presentation in 2007, had localized disease to supraglottic region with ipsilateral neck node involvement. Despite a disease-free interval of 2 years, the presentation with distant cutaneous metastases heralded rapid dissemination of the disease. This case underscores the importance of considering metastases in the differential diagnosis of a new swelling appearing in a patient previously treated for head and neck cancer.

   References Top

1.Robin PE, Olofsson J. Tumour of larynx In: Stell PM, editor. Scott Brown's otolaryngosclogy-Laryngology. 5 th ed. London: Butterworth and Co Ltd.; 1987. p. 184-234.  Back to cited text no. 1
2.Calhoun KH, Fulmer P, Weiss R, Hokanson JA. Distant metastases from head and neck squamous cell carcinoma. Laryngoscope 1994;104:1199-205.  Back to cited text no. 2
3.Merino OR, Lindberg RD, Fletcher GH. An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 1977;40:145-51.  Back to cited text no. 3
4.Zbären P, Lehmann P. Frequency and sites of distant metastases in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 1987;113:762-4.  Back to cited text no. 4
5.Shingaki S, Suzuki I, Kobayashi T, Nakajima T. Predicting factors for distant metastases in head and neck carcinoma: An analysis of 103 patients with loco regional control. J Oral Maxillofac Surg 1996;54:853-7.  Back to cited text no. 5
6.Brownstein MH, Helwig EB. Pattern of cutaneous metastases. Arch Dermatol 1972:105;862-8.  Back to cited text no. 6
7.Veraldi S, Cantu A 2 nd , Sala F, Schianchi R, Gasparini G. Cutaneous metastases from laryngeal carcinoma. J Dermatol Surg Oncol 1988;14:562-4.  Back to cited text no. 7
8.Horiuchi N, Tagami H. Skin metastases in laryngeal carcinoma. Clin Exp Dermatol.1992;17:282-3.  Back to cited text no. 8
9.Debois JM. Skin metastases from a laryngeal carcinoma: Report of a case. Cutis 1996;57:264-6.  Back to cited text no. 9
10.Kmucha ST, Troxel JM. Dermal metastases in epidermoid carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 1993;119:326-30.  Back to cited text no. 10
11.Batson OV. The role of the vertebral veins in metastatic processes. Ann Intern Med 1942;16:38-45.  Back to cited text no. 11
12.Cole RD, McGuirt WF. Prognostic significance of skin involvement from mucosal tumors of the head and neck. Arch Otolaryngol Head Neck Surg 1995;121:1246-8.  Back to cited text no. 12


  [Figure 1], [Figure 2], [Figure 3]

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