IJD
Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
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CASE REPORT
Year : 2011  |  Volume : 56  |  Issue : 5  |  Page : 573-575

Unusual clinicopathological and immunological presentation of chronic bullous dermatosis of childhood (linear IgA dermatosis)


1 Department of Dermatology, King Khalid University Hospital and King Saud University, Riyadh, Kingdom of Saudi Arabia
2 Department of Histopathology, King Khalid University Hospital and King Saud University, Riyadh, Kingdom of Saudi Arabia

Correspondence Address:
Al-Saif Fahad
Department of Dermatology, King Khalid University Hospital, P.O. Box 2925, Riyadh 11461
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.87159

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Linear IgA bullous dermatosis is a rare sulfone-responsive subepidermal blistering disorder of unknown etiology in which smooth linear deposits of IgA are found in the basement membrane zone. Chronic bullous dermatosis of childhood is equivalent to linear IgA disease of adulthood and is characterized by an abrupt onset of large, widespread and tense bullae on a normal or erythematous base. In this case, we describe an unusual presentation of chronic bullous dermatosis in a 14-month-old Saudi girl. Histopathological examination revealed subepidermal cell poor blisters with linear deposition of IgA, IgG, IgM, and C3 along the dermoepidermal junction. The unusual clinical, histopathological and immunofluorescence findings in this patient are discussed, with an account on the differential diagnosis in such cases along with a detailed review of the relevant literature.


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