Indian Journal of Dermatology
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Year : 2011  |  Volume : 56  |  Issue : 4  |  Page : 389-392

A clinical study of 125 patients with phrynoderma

1 Department of Dermatology, Venereology and Leprosy, Shri B.M. Patil Medical College, Hospital and Research Centre, BLDE University, Bijapur, India
2 Department of Dermatology, Venereology and Leprosy, S.S. Institute of Medical Sciences, Davangere, India
3 Department of Dermatology, Venereology and Leprosy, J.J.M. Medical College, Davangere, India

Correspondence Address:
S Ragunatha
Department of Dermatology, Venereology and Leprosy, Shri B.M. Patil medical College, Hospital and Research Centre, BLDE University, Bijapur 586 103, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.84760

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Background: Phrynoderma is a type of follicular hyperkeratosis. Various nutritional deficiency disorders have been implicated in the etiology of phrynoderma. Aim: To determine clinical features of phrynoderma and its association with nutritional deficiency signs. Materials and Methods: A cross-sectional descriptive study of 125 consecutive patients with phrynoderma attending the outpatient department (OPD) of dermatology was conducted in a tertiary care hospital. In all patients, a detailed history was taken and cutaneous examination findings such as distribution, sites of involvement, morphology of the lesions, and signs of nutritional deficiencies were noted. Results: The proportion of patients with phrynoderma attending the OPD was 0.51%. There were 79 males and 46 females. Age of the patients was in the range of 3-26 years with a mean of 10 ΁ 4.3 years. The lesions were asymptomatic in 114 (91.2%) patients. The distribution of lesions was bilateral and symmetrical in 89 (71.2%) patients. The disease was localized (elbows, knees, extensor extremities, and/or buttocks) in 106 (84.8%) patients. The site of onset was elbows in 106 (84.8%) patients. The lesions were discrete, keratotic, follicular, pigmented or skin colored, acuminate papules in all patients. Signs of vitamin A and vitamin B-complex deficiency were present in 3.2% and 9.6% patients, respectively. Epidermal hyperkeratosis, follicular hyperkeratosis, and follicular plugging were present in the entire biopsy specimen. Conclusion: Phrynoderma is a disorder with distinctive clinical features and can be considered as a multifactorial disease involving multiple nutrients, local factors like pressure and friction, and environmental factors in the setting of increased nutritional demand.

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