The comparison between trichloroacetic acid 50% and CO 2 laser in the treatment of cutaneous leishmaniasis scar

Mohammad Ali Nilforoushzadeh; Fariba Jaffary; Nazli Ansari; Shahram Moradi; Amir Hossein Siadat

doi:10.4103/0019-5154.80411

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THERAPEUTIC ROUND

Year : 2011 | Volume : 56 | Issue : 2 | Page : 171-173

The comparison between trichloroacetic acid 50% and CO ₂ laser in the treatment of cutaneous leishmaniasis scar

Mohammad Ali Nilforoushzadeh¹, Fariba Jaffary², Nazli Ansari³, Shahram Moradi³, Amir Hossein Siadat⁴
¹ Professor of Dermatology, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
² Professor of Pharmacology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
³ Researcher, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
⁴ Professor of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Amir Hossein Siadat
Khoram St, After shahidan Sq. Sedigheh Tahereh Research Centers, Third floor Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan
Iran

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0019-5154.80411

Background: The scars of the cutaneous leishmaniasis and psychological problems of this disease need different interventions for its correction. Aim: Our objective in this study was to compare the efficacy of 50% trichloroacetic acid (TCA) solution and CO ₂ laser for treatment of the atrophic scars due to leishmaniasis. Materials and Methods: This was a randomized clinical trial performed in 92 patients. Patients were randomized into two groups: the first group was treated with 50% TCA solution, once monthly and for a maximum of 5 months, and the second group was treated with CO ₂ laser which was performed for only one time. Patients were followed-up at 3 and 6 months after starting the treatment. The improvement of scar was graded by a 6-point scale using digital camera and the collected data were analyzed using SPSS software. Results: In this study, 74 females and 18 males were enrolled. The improvement of scar was 48.13% in the TCA group and 44.87% in the CO ₂ laser group. This difference was not statically significant (P = 0.55). There was also no significant difference regarding side effects between these two groups. Conclusion: The results of our study showed that efficacy of focal with 50% TCA solution is compared with CO ₂ laser in treatment of leishmaniasis scar. Because of the low cost and simple application of TCA solution in comparison with CO ₂ laser, we suggest use of this treatment for correction of leishmaniasis scar or the atrophic scars.

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