Indian Journal of Dermatology
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Table of Contents 
Year : 2010  |  Volume : 55  |  Issue : 4  |  Page : 411-412
Migratory polycyclic lesions with facial eczema since infancy

Department of Skin and STD, Kasturba Hospital, Manipal, Karnataka, India

Date of Web Publication4-Jan-2011

Correspondence Address:
Vandana Mehta
Assistant Professor, Department of Skin and STD, KMC, Manipal, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.74578

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How to cite this article:
Monga P, Mehta V, Balachandran C. Migratory polycyclic lesions with facial eczema since infancy. Indian J Dermatol 2010;55:411-2

How to cite this URL:
Monga P, Mehta V, Balachandran C. Migratory polycyclic lesions with facial eczema since infancy. Indian J Dermatol [serial online] 2010 [cited 2022 Sep 30];55:411-2. Available from:

A 16 year old boy, first child of consanguineous parents presented with a generalized scaly eruption with a waxing and waning course since infancy.

His physical and intellectual development was normal and there was no history of colloidian membrane or any vesiculobullous lesions. Patient gave history of recurrent rhinitis since childhood however there was no family history of atopy or similar skin lesions. Cutaneous examination revealed widespread erythematous, serpiginous, annular and polycyclic, scaly plaques over face, trunk, upper and lower extremities [Figure 1] and [Figure 2]. Lichenification of flexures was present with hyperkeratotic plaques in the neck [Figure 3]. Scalp hair was short and coarse, however nail, genitalia and mucous membrane were normal. Biopsy features from the scaly plaque on the forearm are shown in [Figure 4].
Figure 1 :Facial eczema since infancy

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Figure 2 :Close up view of the scaly plaques on the forearm showing the characteristic double edge scale

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Figure 3 :Hyperkeratotic plaque on the neck

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Figure 4 :Photomicrograph showing the hyperkeratotic epidermis, parakeratosis and accentuation of the granular layer (H and E, x400)

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   References Top

1.Comel M. Ichthyosis linearis circumflexa. Dermatologica 1949;98:133-6  Back to cited text no. 1
2.Judge MR, Morgan G, Harper JI. A clinical and immunological study of Netherton's syndrome. Br J Dermatol 1994;131:615-21.   Back to cited text no. 2
3.Sun JD, Linden KG. Netherton syndrome: A case report and review of the literature. Int J Dermatol 2006;45:693-7.   Back to cited text no. 3
4.Netherton EW. A unique case of trichorrehexis nodosa-"bamboo hairs".Arch Dermatol 1958,78:483-7.  Back to cited text no. 4
5.Altamn J, Stroud J. Netherton's syndrome and ichthyosis linearis circumflexa. Arch Dermatol 1969;100:550-8.  Back to cited text no. 5
6.Chavanas S, Bodemer C, Rochat A, Hamel-Teillac D, Ali M, Irvine AD, et al. Mutations in SPINKS, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 2000;25:141-2.  Back to cited text no. 6
7.Smith DL, Smith JG, Wong SW, deShazo RD. Netherton's syndrome:A syndrome of elevated IgE and characteristic skin and hair findings. J Allergy Clin Immun 1995:95:116-23.  Back to cited text no. 7
8.Greene SL, Muller SA. Netherton's syndrome. Report of a case and review of literature. J Am Acad Dermatol 1985;13:329-37.  Back to cited text no. 8
9.Manabe M, Yoshiike T, Negi M, Ogawa H. Successful therapy of ichthyosis linearis circumflexa with PUVA. J Am Acad Dermatol 1983;8:905-7.   Back to cited text no. 9
10.Malakar S, Lahiri K, Sengupta SR. Ichthyosis linearis circumflexa. Indian J Dermatol Venereol Leprol 1996;62:379-80  Back to cited text no. 10


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]


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