Indian Journal of Dermatology
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Year : 2010  |  Volume : 55  |  Issue : 2  |  Page : 171-175

Targeting IL-23: Insights into the pathogenesis and the treatment of psoriasis

1 Department of Medical Pathology, Federal University of Parana - Curitiba, PR - Brazil
2 Department of Dermatology, Clinical Unit for Research Trials in Skin - Massachusetts General Hospital, Harvard Medical School - Boston, MA - USA

Correspondence Address:
Hermenio Cavalcante Lima
Associate Professor, Division of Dermatology, Department of Medicine. 1200 Main St. W. Hamilton Ontario L8N 3Z5, Canada

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.62760

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Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis. Studies with anti-IL-12/23 therapeutic agents, which act in different steps of the psoriatic inflammatory cascade, have also shown demonstrable efficacy. Here, we discuss this approach and its potential within the armamentarium for the treatment of psoriasis. Evidences that the selective blocking of IL-23 may be effective and safe therapy are also addressed.

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