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Year : 2010  |  Volume : 55  |  Issue : 1  |  Page : 120-121
Erythema annulare centrifugum in pregnancy

1 Department of Dermatology, Çankiri State Hospital, 18200 Çankiri, Turkey
2 Department of Dermatology, Baskent University Faculty of Medicine, Ankara, Turkey

Date of Web Publication4-Mar-2010

Correspondence Address:
Engin Senel
Department of Dermatology, Çankiri State Hospital, 18200 Çankiri
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.60371

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How to cite this article:
Senel E, Gulec AT. Erythema annulare centrifugum in pregnancy. Indian J Dermatol 2010;55:120-1

How to cite this URL:
Senel E, Gulec AT. Erythema annulare centrifugum in pregnancy. Indian J Dermatol [serial online] 2010 [cited 2021 Mar 5];55:120-1. Available from: https://www.e-ijd.org/text.asp?2010/55/1/120/60371


Erythema annulare centrifugum (EAC), the most common form of gyrate erythemas, was first introduced in 1916 by Darier. [1] EAC has been considered to be related to various etiological factors including infections, immunological disorders, malignancy, drugs and foods. However, no disorders, medications or infectious agents have been convincingly linked to the development of EAC. [1],[2]

A 28-year-old woman presented with a one-month history of asymptomatic skin eruption which appeared in the 26 th week of her first pregnancy. Her medical history was unremarkable. Dermatological examination disclosed multiple annular plaques with a trailing scale at the inner border of the erythema on her abdomen and extremities [Figure 1]. Direct microscopic examination did not reveal any fungal hyphae. Histopathology showed mild hyperkeratosis, mild focal parakeratosis, spongiosis in the epidermis, and partially well demarcated perivascular lymphocytic infiltrate around the blood vessels in a sleeve like arrangement in the superficial dermis [Figure 2] and [Figure 3].

The patient was diagnosed with EAC. Complete blood count, indices of renal, hepatic and thyroid functions, antinuclear antibody test, C-reactive protein, antistreptolysine-O, urinary analysis and stool examination were in normal limits. Since she was pregnant, no therapy was planned. All her lesions resolved gradually in seven weeks. No recurrence was noted during pregnancy and on a four-month follow-up after delivery.

Majority of the cases with EAC are idiopathic. [3] Hormonal changes (elevation of serum estrogen and progesterone levels), which occur during pregnancy might have caused EAC in our patient.

Although EAC is the most common form of the figurate erythemas, there are only two pregnant cases with EAC reported in the literature. [1],[2] Rosina et al. reported a 28-year-old woman with a two-week history of EAC lesions on her extremities in the 33 rd week of her first pregnancy. [1] Choonhakarn and Seramethakun also reported a similar case with EAC lesions on her abdomen and extremities in the 29 th week of her first pregnancy. [2] No etiological factor was detected in these patients, and their lesions cleared spontaneously. The authors proposed that increasing estrogen level in pregnancy might be the possible cause of EAC in these patients. [1],[2]

Progesterone, a 21-carbon steroid hormone involved in the female menstrual cycle, is also a sine qua non for the establishment and maintenance of pregnancy. The association between EAC and progesterone has been described in the literature. Halevy et al. reported a 28-year-old woman with the cyclic annular pruritic lesions aggravated a few days before menstruation in the high progesterone period of the cycle. The authors showed that in vivo intradermal progesterone test revealed an immediate-type response and higher IFN-γ release was detected for progesterone in the patient. They suggested that these EAC lesions could be a manifestation of the autoimmune progesterone dermatitis (AIPD). [4]

EAC can occur very rarely in pregnancy and hormonal changes such as significant elevation of estrogen and/or progesterone hormones level may be its possible cause. EAC in pregnancy might be a limited manifestation of AIPD during pregnancy.

   References Top

1.Rosina P, D'Onghia FS, Barba A. Erythema annulare centrifugum and pregnancy. Int J Dermatol 2002;41:516-7.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]  
2.Choonhakarn C, Seramethakun P. Erythema annulare centrifugum associated with pregnancy. Acta Derm Venereol 1998;78:237-8.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]  
3.Weyers W, Diaz-Cascajo C, Weyers I. Erythema annulare centrifugum: Results of a clinicopathologic study of 73 patients. Am J Dermatopathol 2003;25:451-62.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]  
4.Halevy S, Cohen AD, Lunenfeld E, Grossman N. Autoimmune progesterone dermatitis manifested as erythema annulare centrifugum: Confirmation of progesterone sensitivity by in vitro interferon-gamma release. J Am Acad Dermatol 2002;47:311-3.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]  


  [Figure 1], [Figure 2], [Figure 3]

This article has been cited by
1 Pregnancy-associated erythema annulare centrifugum
Chi-Hsuan Chiang,Feng-Jie Lai
Journal of the Formosan Medical Association. 2014;
[Pubmed] | [DOI]


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