Indian Journal of Dermatology
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Year : 2009  |  Volume : 54  |  Issue : 1  |  Page : 20-22

Serum leptin, atherogenic lipids and glucose levels in patients with skin tags

1 Department of Dermatology, Fatih University Faculty of Medicine, Ankara, Turkey
2 Department of Dermatology, Mesa Hospital, Ankara, Turkey
3 Department of Biochemistry, Mesa Hospital, Ankara, Turkey
4 Department of Biochemistry, Konya Hospital of The Turkish Health and Therapy Foundation, Konya, Turkey

Correspondence Address:
Canan Gorpelioglu
Department of Dermatology, Fatih University Faculty of Medicine, Hosdere Cad. No:145-147 06540/ Y, Ayranci, Ankara
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.48980

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Aim: To investigate the relationship between serum leptin, atherogenic lipid and glucose levels in patients with skin tags and healthy controls. Materials and Methods: A total of 58 patients, with at least three skin tags, aged 24 to 85 years, and 31 healthy controls aged 30 to 70 years, were examined in the present study. The subjects in all the groups were selected with statistically similar Body Mass Index (BMI). Fasting concentrations of plasma glucose, serum lipids including triglyceride, total cholesterol, and high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL), HbA1c, and leptin were measured by enzyme-linked immunosorbent assay (ELISA). In addition, serum LDL level was calculated using Friedewald's formula. Results: There was no significant difference in age, sex, BMI, HbA1c, triglyceride, HDL and leptin levels between the groups. Skin tags group showed significantly higher levels of total cholesterol and LDL, when compared with the healthy controls groups ( P < .001). In addition, regression analysis showed that leptin level was positively correlated to serum triglyceride level (r = 0.265, P = 0.044). Conclusion: Total cholesterol and LDL serum levels should be controlled in patients with skin tags. On the other hand, glucose, leptin and HbA1c serum levels may not be as important as is being considered in recent times.

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