Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
Users online: 1221  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page

Year : 2008  |  Volume : 53  |  Issue : 1  |  Page : 41-43
Subcutaneous rhinosporidiosis

1 Department of Skin and VD, MKCG Medical College and Hospital, Berhampur - 760 010, Orissa, India
2 Department of Surgery, MKCG Medical College and Hospital, Berhampur - 760 010, Orissa, India
3 Department of Pathology, MKCG Medical College and Hospital, Berhampur - 760 010, Orissa, India

Correspondence Address:
Surajit Nayak
Department of Skin and VD, MKCG Medical College and Hospital, Berhampur - 760 010, Orissa
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.39746

Rights and Permissions

How to cite this article:
Nayak S, Rout TK, Acharjya B, Patra MK. Subcutaneous rhinosporidiosis. Indian J Dermatol 2008;53:41-3

How to cite this URL:
Nayak S, Rout TK, Acharjya B, Patra MK. Subcutaneous rhinosporidiosis. Indian J Dermatol [serial online] 2008 [cited 2023 Oct 3];53:41-3. Available from:

Rhinosporidiosis is a chronic granulomatous disease involving man and lower animals, caused by Rhinosporidium seeberi , endemic in South India and Sri Lanka. The disease, while being a common presentation for oto-rhino-laryngologists, is of interest to dermatologists as well, because of the cutaneous, subcutaneous presentation in rare cases. Cutaneous and subcutaneous lesions are infrequent and are generally associated with mucosal lesions. We report this rare case of subcutaneous rhinosporidiosis, in absence of any primary mucosal/cutaneous lesions.

The patient, a 23-year-old healthy agricultural labourer, presented to our clinic with multiple, asymptomatic, lobular swellings over the right foot, left thigh, abdomen and back. As narrated by the patient, it all started as a small non-tender swelling over the plantar aspect of the right foot two years back and subsequently similar lesions appeared elsewhere on the body. Patient denied any history of any trauma in the past. Examination revealed cystic swellings of different sizes, ranging from 4 cm to 8 cm over different parts as specified earlier [Figure - 1],[Figure - 2]. All were non-tender, ill-defined with an overlying normal-colored skin. There was no regional lymphadenopathy and the rest of the clinical examination was normal. Routine laboratory tests and biochemical parameters were within normal limits. Patient denied any sexual contact in the recent past; VDRL and ELISA test for HIV was negative. A FNAC was advised which showed sporangia at various stages of development, subsequently confirmed by excisional biopsy [Figure - 3],[Figure - 4]. A clinico-pathological diagnosis of subcutaneous rhinosporidiosis was made. An ultrasonogram and X-Ray chest excluded internal involvement. Patient was referred to surgeon for excision of individual lesions. He was discharged and was advised to take dapsone (100 mg/daily) and asked to report for regular follow-up.

Though rhinosporidiosis and the etiological agent Rhinosporidium seeberi, is known for over a hundred years and was first described in Argentina, [1] the as yet unresolved enigmas in rhinosporidiosis include the mode of infection, mechanisms of spread, mechanisms of immunity, some aspects of histopathology, e.g. the significance of transepidermal elimination of sporangia, the cause of the variation in cell infiltration patterns in rhinosporidial tissues and their correlations with immune status and the absence of the Splendore-Hoeppli reaction which is well-marked in invasive, classical mycoses. Infection is usually caused by contact with stagnant fresh water such as swimming pools. R. seeberi had first been regarded as a sporozoan by Malbran, its discoverer, in 1892, as a protozoan by Seeber who first published a description of the pathogen and then, as a phycomycete by Ashworth in 1923. [2] Its taxonomic position is unclear till date, but a recent isolation of a prokaryotic cyanobacterium Microcystis aeruginosa by Ahluwalia et al. [3] from water samples of ponds and rivers where patients were bathing and detection of both large cells and nanocytes of M . aeruginosa inside round bodies of rhinosporidiosis by light and electron microscope has virtually ended all etiological controversies surrounding rhinosporidiosis. This new finding may reinforce the justification for a change in the name "rhinosporidiosis" that has been traditionally associated with the fungus R. seeberi . It is characterized by the development of pedunculated and sessile polypoid lesions on the mucosa of the nose, eyes, larynx, penis and rarely on other parts of the body like skin. Subcutaneous lesions are extremely rare and very few cases presenting only as a subcutaneous mass have been reported. It is a chronic disease, with frequent recurrence after surgery and occasional dissemination from the initial focus, that is most commonly seen in upper respiratory sites, was not observed in our case. This type of presentation needs to be differentiated from lipoma, sebaceous cyst and fibroma and disseminated pheohyphomycosis. As there are many reports of rhinosporidiosis of different types by different authors, clinical presentation is no more a mystery and I will be highlighting a little more about the etiolological agent and its unsolved enigmas in shadow of recent studies in my discussion. Rhinosporidiosis is an infective disease in the sense that the tissue lesions are always associated with the presence of the pathogen. No evidence has been adduced that it is also an infectious disease, as no transmission has ever been documented of cross-infection between members of the same family or between animals and humans. A curious feature in the incidence of the disease is that while several hundreds of persons bathe in stagnant waters, as in our country, only a few develop progressive disease; this might indicate the existence of predisposing, though obscure, factors in the host. The only patient factor on which there is some data is blood groups. In India the highest incidence of rhinosporidiosis was in Group O (70%) though in the population Groups A, B and O are distributed "fairly equally"; the next highest incidence was in Group AB though in the general population Group AB is rare. [4] Jain, [5] in India, reported that the blood group distribution was too variable to draw any conclusion. The presumed mode of infection from the natural aquatic habitat of R. seeberi , is through the traumatized epithelium ('transepithelial infection') [6] most commonly in nasal sites, but there is evidence for hematogenous and lymphatic spread of rhinosporidiosis to anatomically distant sites. [7] The development of subcutaneous granulomata in the plantar aspect of the right foot, without breach of the overlying skin, as seen in our case could be attributed to any trivial trauma not noticed by the patient and subsequent hematogenous dissemination. Autoinoculation was considered by Karunaratne [8] in his classical monograph on rhinosporidiosis, to be the explanation for the occurrence of satellite lesions adjacent to granulomas, especially in the upper respiratory sites and for local spread. In the absence of pure preparations of the developmental stages of R. seeberi , uncontaminated by host tissue and other micro-organisms and consequently the absence of specific tests for immune responses in diseased hosts, it is not surprising that there was very little data, till recently, on the immune responses in rhinosporidiosis. The only report on tests for anti-rhinosporidial antibody in human patients was by Chitravel et al. [9] where no antibody was detected in double diffusion or CIE tests. The CMI responses (CMIR) in human rhinosporidiosis were re-examined recently [10] by immunohistology with monoclonal antibodies to specific cell markers on cells in rhinosporidial tissues, which showed that the cell infiltrate in human rhinosporidial polyps was mixed, having consisted of many plasma cells, fewer CD 68+ macrophages, CD 3+ and CD 56/57+ NK lymphocytes which were positive for CD 3 as well; CD 4+ lymphocytes were present though scarce. CD 8+ suppressor/cytotoxic lymphocytes were numerous and most of the CD 8+ cells were TIA-1+ and therefore of the cytotoxic subtype.

Although cases of spontaneous regression have been recorded, they are rare and the mode of treatment remains surgical. Total excision of the polyp, preferably by electro-cautery, is recommended. The failure to propagate R. seeberi in vitro , with the inability to establish experimental rhinosporidiosis, have prevented the determination of the sensitivity of R. seeberi to drugs that might have clinical application. While several anti-bacterial and anti-fungal drugs have been tested clinically, but unsuccessfully, the only drug which was found to have some anti-rhinosporidial effect is dapsone (4,4-diaminodiphenyl sulphone) [11],[12] which appears to arrest the maturation of the sporangia and to promote fibrosis in the stroma, when used as an adjunct to surgery.

   References Top

1.Arseculeratne SN. Recent advances in rhinosporidiosis and Rhinosporidium seeberi . Indian J Med Microbiol 2002; 20:119-31.  Back to cited text no. 1    
2.Ashworth JH. On Rhinosporidium seeberi (Wernicke, 1903) with special reference to its sporulation and affinities. Trans Roy Soc Edin 1923;53:301-42.  Back to cited text no. 2    
3.Ahluwalia KB, Maheshwari N, Deka RC. Rhinosporidiosis: A study that resolves etiologic controversies. Am J Rhinol 1997;11:479-83.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Kameswaran S, Lakshmanan M. Rhinosporidiosis. In : ENT disorders in a tropical environment . In : Kameswaran S, Kameswaran M, editors. MERF Publications: Chennai; 1999. p. 19-34.  Back to cited text no. 4    
5.Jain S. Aetiology and incidence of rhinosporidiosis. Indian J Otorhinol 1967;19:1-21.  Back to cited text no. 5    
6.Karunaratne WA. The pathology of rhinosporidiosis. J Pathol Bact 1934;52:193-202.  Back to cited text no. 6    
7.Rajam RV, Viswanathan GC. Rhinosporidiosis: A study with a report of a fatal case with systemic dissemination. Indian J Surg 1955;17:269-98.  Back to cited text no. 7    
8.Karunaratne WA. Rhinosporidiosis in man. The Athlone Press: London; 1964.  Back to cited text no. 8    
9.Chitravel V, Sundararaj T. Detection of circulating antigen in patients with rhinosporidiosis. Sabouraudia 1982;20:185-91.  Back to cited text no. 9    
10.De Silva NR, Huegel Heino, Atapattu DN, et al. Cell-mediated immune responses in human rhinosporidiosis. Mycopathologia 2001;152:59-68.  Back to cited text no. 10    
11.Nair KK. Clinical trial of diaminodiphenylsulphone (DDS) in nasal and nasopharyngeal rhinosporidiosis. Laryngoscope 1979;89:291-5.  Back to cited text no. 11  [PUBMED]  
12.Job A, Venkateswaran S, Mathan M, Krishnaswami H, Raman R. Medical therapy of rhinosporidiosis with dapsone. J Laryngol Otol 1993;107:809-12.  Back to cited text no. 12  [PUBMED]  


  [Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4]

This article has been cited by
1 Disseminated rhinosporidiosis masquerading as soft tissue round cell tumour diagnosed by fine needle aspiration cytology
Vidhya Vikashini Balasubramaniam, Subhashini Ramamoorthi, Naadia Nadeem, Mithraa Devi Sekar, Debasis Gochhait, Neelaiah Siddaraju
Cytopathology. 2022;
[Pubmed] | [DOI]
2 Disseminated cutaneous rhinosporidiosis: Revisited
Sumit Sen, Widhi Agrawal, Somnath Das, ParthaS Nayak
Indian Journal of Dermatology. 2020; 65(3): 204
[Pubmed] | [DOI]
3 Dermatological aspects of rhinosporidiosis
Sarath Nanda Arseculeratne,Gehan Arseculeratne
Expert Review of Dermatology. 2013; 8(1): 83
[Pubmed] | [DOI]


Print this article  Email this article
   Next article
   Previous article 
   Table of Contents
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (147 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

    Article Figures

 Article Access Statistics
    PDF Downloaded162    
    Comments [Add]    
    Cited by others 3    

Recommend this journal