Source of Support: None, Conflict of Interest: None
This study was done to validate the role of immunoprecipitation (IP) in the diagnosis of subepidermal blistering disorders. IP assay was done in 21 cases and 9 controls using a standard protocol. Thirty three percent of bullous pemphigoid, 33% of liner IgA dermatoses and 40% of CBDC precipitated the disease specific antigens. IP in controls (9) detected specific BP antigens in 3 and specific EBA antigens in 2. This Study highlights the high specificity but low sensitivity of IP test in subepidermal blistering disorders.