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The present study was undertaken to assess the response of three topical regimes in patients of mild to moderate plaque psoriasis. A total of 90 patients were randomly divided into three treatment groups of 0.05% clobetasol propionate, coal tar 6% with salicylic acid 3 % and methorexate 0.25% in a hydroxy gel. The regimes were tried for 12 weeks and followed up for one year. The lesions were assessed for response in terms of psoriasis area severity index (PASI). The results were analysed among 73 patients (49 males and 24 females) of age 12-65 years (mean 34.25 +-10.65), which were similar with respect to age, sex ratio, duration of the disease and surface area involved (p>.05) among different treatment groups. Maximum fall in the methotrexate 45.87% (5.08 to 2.75). To the contrary maximum relapse was seen which clobetasol propionate 20/25 (77%) followed by 11/26 (44%) with coal tar and minimum with methotrexate 4/22 (4%). All the treatment regimes were effective in inducing remission in psoriasis but response with clobetasol and coal tar was better than with methotrexate. Relapse during follow up period was more common with clobetasol propionate.