Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
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Year : 2002  |  Volume : 47  |  Issue : 2  |  Page : 76-79

Comparative Evaluation Of Topical Preparations In Treatment of Melasma

Correspondence Address:
Roma Pandhi

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Fifty patients of melasma were randomly taken up for the study and were divided into five treatment groups of 10 patients each. Patients of these groups received clobetasol propionate 0.05% (group I), tretinoin 0.025% (group II), hydroquinone 2% (group III), bebzoyl peroxide 5% (group IV) and glycolic acid 10% (group V). Pretreatment evolution was done with MASI (melasma area severity index) scoring and photographic records. Patients were treated for 3 months and the preparations were found to be equally compatible to our patients. However, effectiveness on an average was higher for clobetasol (80%) and tretinoin (62%), though hydroquinone (48%), benzoyal peroxide (41%) and glycolic acid (30%) also showed fairly good results. Our study broadens the therapeutic spectrum of melasm by using agents with different mechanisms of action.

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