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Digital capillary flow in pseudoxanthoma elasticum (PXE) was measured by a highly sensitive, non-invasive technique called photoplethysmography (PPG). In total 3 patients (2 females, 1 male) of PXE aged between 21 to 37 years suffering for 3 to 8 years were studied along with 3 control (normal) subject (2 females, 1 male) aged between 20 to 41 years. PPG recordings were done by applying the PPG probe serially to the distal phalanges of all digits of four limbs with Velcro-strap at an ambient temperature of 26-310C and humidity 60-65%. In all cases of PXE the capillary flow was normal in all the digits similar to control subjects.