Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
Users online: 6027  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
Year : 2001  |  Volume : 46  |  Issue : 1  |  Page : 1-7

Systemic Corticosteroid Therapy And The Hypothalamopituitary-Adrenal Axis

Correspondence Address:
M Ramam

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Adrenal crisis due to suppression of the HPA axis by systemic corticosteroid therapy is a much feared complication which, however, appears to be quite uncommon. In an individual patient, the status of the HPA axis cannot be reliably predicted based on the dose and duration of therapy. Further, the response to stress does not always correlate with the results of tests of HPA function. However, HPA axis suppression is generally associated with daily dosing, high doses and prolonged duration of therapy. The dose, duration and schedule of administration of corticosteroids should be tailored to the needs of the individual patient and his disease. HPA axis suppression need not be considered in acute, inflammatory diseases. In other steroid-responsive dermatoses, intermittent dosing schedules are likely to produce fewer side effects including suppression of the HPA axis. As a measure of caution, patients who have received systemic corticosteroids in the past may be administered supplemental corticosteroids during stressful situations (though not all of them will need it).

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded149    
    Comments [Add]    

Recommend this journal